{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.4","value":"46.1"},{"groupId":"OG001","spread":"0.3","value":"40.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"25"}],"units":"Participants"}],"title":"Baseline"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.8","value":"51.1"},{"groupId":"OG001","spread":"0.4","value":"40.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"22"}],"units":"Participants"}],"title":"3 Months"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.3","value":"48.3"},{"groupId":"OG001","spread":"0.4","value":"40.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"20"}],"units":"Participants"}],"title":"6 Months"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.0","value":"48.9"},{"groupId":"OG001","spread":"0.5","value":"41.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"20"}],"units":"Participants"}],"title":"9 Months"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.7","value":"49.4"},{"groupId":"OG001","spread":"0.4","value":"44.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"17"}],"units":"Participants"}],"title":"12 Months"}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"25"}],"units":"Participants"}],"description":"Subjects will complete the Patient Reported Outcomes Measurement Information System Global Health instrument, a 10-item standardized patient-reported outcome measure that provides global ratings of physical function, fatigue, pain, emotional distress to report on common domains of health-related quality of life. The survey comprises a series of 5-response Likert-style questions. For each question, a low score indicates lesser or absent symptom or condition and higher indicates more severe symptom or condition (e.g., 1= None to 5=Very severe). Automated scoring produces a T-score for each domain. This measure reports the physical health score. T-scores for this domain range from 16.2 to 67.7. Higher scores indicate poorer physical health.","dispersionType":"Standard Deviation","groups":[{"description":"Doxycycline will be administered at dose of 100mg orally twice daily for 1 year.\n\nDoxycycline: Doxycycline will be continued until one of the following criteria is met:\n\n* Patient has completed 1 year of doxycycline therapy\n* Patient develops any grade 3-4 toxicity related to doxycycline use.","id":"OG000","title":"Doxycycline (Localized Disease)"},{"description":"Doxycycline will be administered at dose of 100mg orally twice daily for 1 year.\n\nDoxycycline: Doxycycline will be continued until one of the following criteria is met:\n\n* Patient has completed 1 year of doxycycline therapy\n* Patient develops any grade 3-4 toxicity related to doxycycline use.","id":"OG001","title":"Doxacycline (Systemic Disease)"}],"paramType":"MEAN","populationDescription":"One subject in the Localized cohort withdrew consent prior to the 6-month visit. Five subjects in the Systemic Disease cohort expired during the course of the study; two subjects came off study; and one was lost to follow-up.","reportingStatus":"POSTED","timeFrame":"Baseline, 3, 6, 9 and 12 months","title":"Patient-reported Health Quality of Life","type":"SECONDARY","unitOfMeasure":"score on a scale"}