{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"80"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"19"}],"units":"Participants"}],"description":"Determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D): Selinexor on Days 1, 8 and 15 when given in combination with Lipodox 20 mg/m\\^2 and Dexamethasone 40 mg.\n\nDose level 1: 40 mg in combination with Lipodox and Dexamethasone.\n\nDose level 2: 80 mg (D1,8,15) in combination with Lipodox and Dexamethasone.\n\nDose level 2m: 80 mg (D1,8,15) in combination with Lipodox and Dexamethasone.\n\nDose level 3m: 80 mg (D1,3,8,10) in combination with Lipodox and Dexamethasone.","groups":[{"description":"Combination Therapy: Phase I Dose Escalation followed by Phase 2 treatment at Recommended Phase 2 Dose (RP2D)","id":"OG000","title":"Selinexor, Liposomal Doxorubicin and Dexamethasone"}],"paramType":"NUMBER","populationDescription":"All participants treated during dose escalation","reportingStatus":"POSTED","timeFrame":"Up to 12 months","title":"Maximum Tolerated Dose (MTD)","type":"PRIMARY","unitOfMeasure":"mg"}