{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.7787","value":"27.919"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"381"}],"units":"Participants"}],"title":"Cycle 1 Day 1: 1 Hour Post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.8078","value":"10.352"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"383"}],"units":"Participants"}],"title":"Cycle 1 Day 1: 4 Hours Post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.6707","value":"1.584"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"387"}],"units":"Participants"}],"title":"Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.4305","value":"2.611"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"382"}],"units":"Participants"}],"title":"Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.0984","value":"1.946"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"384"}],"units":"Participants"}],"title":"Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"2.0069","value":"3.232"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"374"}],"units":"Participants"}],"title":"Cycle 2 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.1508","value":"2.258"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"367"}],"units":"Participants"}],"title":"Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.7822","value":"2.396"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"367"}],"units":"Participants"}],"title":"Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.4921","value":"2.400"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"360"}],"units":"Participants"}],"title":"Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.6994","value":"2.623"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"350"}],"units":"Participants"}],"title":"Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.9842","value":"2.691"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"349"}],"units":"Participants"}],"title":"Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.7074","value":"2.637"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"338"}],"units":"Participants"}],"title":"Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.9380","value":"2.610"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"327"}],"units":"Participants"}],"title":"Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1.9509","value":"2.594"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"321"}],"units":"Participants"}],"title":"Cycle 10 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"393"}],"units":"Participants"}],"description":"Plasma concentrations of the complete hydrolysis product of ixazomib citrate (ixazomib) were measured using a validated Liquid Chromatography-tandem Mass Spectrometry (LC/MS/MS) assay.","dispersionType":"Standard Deviation","groups":[{"description":"Ixazomib citrate 3 mg, capsules, orally, once, on Days 1, 8 and 15 in a 28-day cycle for Cycles 1 through 4. Ixazomib citrate 4 mg, capsules, orally, once, on Days 1, 8 and 15 in a 28-day cycle for Cycles 5 through 26 until PD, unacceptable toxicity, or discontinuation for alternate reasons. Participants who had any dose reductions due to AEs were not dose escalated.","id":"OG000","title":"Ixazomib Citrate"}],"paramType":"MEAN","populationDescription":"The Pharmacokinetic (PK) Analysis Population was defined as participants with at least one PK sample that was collected and analyzed. Number analyzed is the number of participants with data available for analysis at the specified timepoint.","reportingStatus":"POSTED","timeFrame":"Day 1 of Cycle 1: 1 hour and 4 hours post-dose; Predose on Days 8 and 15 of Cycle 1, Days 1 and 8 of Cycle 2, Day 1 of Cycles 3 through 10 (each cycle length= 28 days)","title":"Plasma Concentration of Ixazomib","type":"SECONDARY","unitOfMeasure":"nanograms per milliliter (ng/mL)"}