{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"6"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"description":"An RTT is defined as an adverse event (AE) that occurs within +37 days after transplant or 30 days after the last dose of carfilzomib (day +7), and is considered to be a direct consequence and a related event as a result of the combination of conditioning chemotherapy, GVHD prophylaxis regimen and carfilzomib.","groups":[{"description":"Participants were administered 20 mg/m\\^2 of Carfilzomib on days 1, 2, 6 and 7.","id":"OG000","title":"Dose Level 1 - Maximum Dose Carfilzomib 20 mg/m^2 IV"},{"description":"Participants were administered 20 mg/m\\^2 on days 1 and 2; 27 mg/m\\^2 of Carfilzomib on days 6 and 7.","id":"OG001","title":"Dose Level 2 - Maximum Dose Carfilzomib 27 mg/m^2 IV"},{"description":"Participants were administered 20 mg/m\\^2 on days 1 and 2; 36 mg/m\\^2 of Carfilzomib on days 6 and 7.","id":"OG002","title":"Dose Level 3 - Maximum Dose Carfilzomib 36 mg/m^2 IV"},{"description":"Participants were administered 20 mg/m\\^2 on days 1 and 2; 45 mg/m\\^2 of Carfilzomib on days 6 and 7.","id":"OG003","title":"Dose Level 4 - Maximum Dose Carfilzomib 45 mg/m^2 IV"}],"paramType":"NUMBER","populationDescription":"Subjects who have received at least one dose of carfilzomib were evaluable for toxicities","reportingStatus":"POSTED","timeFrame":"Up to 30 days post treatment","title":"Number of Regimen Related Toxicities (RRTs)","type":"SECONDARY","unitOfMeasure":"Regimen related toxicities"}