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Following treatment completion/discontinuation, participants were followed for safety and efficacy for up to 5 years.","id":"EG000","otherNumAffected":197,"otherNumAtRisk":199,"seriousNumAffected":56,"seriousNumAtRisk":199,"title":"Cohort A: ddAC, Paclitaxel, Pertuzumab, Trastuzumab"},{"deathsNumAffected":13,"deathsNumAtRisk":198,"description":"Participants received neoadjuvant treatment with 5-fluorouracil, epirubicin, and cyclophosphamide (FEC), with administration of 5-fluorouracil 500mg/m\\^2 intravenously (IV) q3w, epirubicin 100mg/m\\^2 IV q3w, and cyclophosphamide 600mg/m\\^2 IV q3w for 4 cycles, followed by docetaxel (with starting dose of 75mg/m\\^2 in Cycle 5, then 100mg/m\\^2 for Cycles 6-8) q3w for 4 cycles. Pertuzumab (840 mg IV loading dose then 420mg IV q3w) and trastuzumab (8 mg/kg IV loading dose then 4mg/kg IV q3w) were given along with doectaxel for 4 cycles (8 cycles of chemotherapy in total prior to surgery). Following surgery, participants received adjuvant treatment with pertuzumab and trastuzumab IV q3w (up to 13 cycles), for a total of 17 cycles of pertuzumab and trastuzumab therapy during the study. Radiotherapy and adjuvant hormonal therapy were also given as clinically indicated. Following treatment completion/discontinuation, participants were followed for safety and efficacy for up to 5 years.","id":"EG001","otherNumAffected":198,"otherNumAtRisk":198,"seriousNumAffected":66,"seriousNumAtRisk":198,"title":"Cohort B: FEC, Docetaxel, Pertuzumab, Trastuzumab"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v23.0","stats":[{"groupId":"EG000","numAffected":56,"numAtRisk":199,"numEvents":65},{"groupId":"EG001","numAffected":64,"numAtRisk":198,"numEvents":78}],"term":"ANAEMIA"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA v23.0","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":199,"numEvents":3},{"groupId":"EG001","numAffected":10,"numAtRisk":198,"numEvents":10}],"term":"FEBRILE NEUTROPENIA"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic 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