{"classes":[{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"5"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"title":"missing"}],"title":"Was the medicine difficult to mix?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"5"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"title":"missing"}],"title":"Was the medicine difficult to measure?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"5"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"title":"missing"}],"title":"Was the medicine difficult to administer?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"4"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"}],"title":"missing"}],"title":"Did the subject like the taste of the medicine?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"2"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"4"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"}],"title":"missing"}],"title":"Did the subject have difficulty in taking the medicine?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"4"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"2"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"}],"title":"missing"}],"title":"Did the subject resist taking the medicine?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"}],"title":"missing"}],"title":"Was the medicine bitter?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"}],"title":"missing"}],"title":"Was the medicine sweet?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"}],"title":"missing"}],"title":"Was the medicine sour?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"}],"title":"missing"}],"title":"Was the medicine gritty?"},{"categories":[{"measurements":[{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"}],"title":"missing"}],"title":"Was the medicine difficult to swallow?"}],"denoms":[{"counts":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"6"}],"units":"Participants"}],"description":"For subjects ≥ 12 years of age who received the dabrafenib suspension, the subject completed a form to evaluate the various properties of the suspension (e.g., bitterness, sweetness, appearance, texture and overall taste). For subjects \\< 12 years of age who received the suspension, their caregiver (e.g. parent or guardian) evaluated the suspension with the child based on verbal and non-verbal feedback. The questionnaire was completed after the first dose of study drug and no later than Day 8 (±3 days). Subjects completed a form for each drug separately if enrolled in Parts C and D.","groups":[{"description":"Participants treated with a combination therapy of trametinib (0.025 mg/kg/day) plus 50% of the RP2D of dabrafenib monotherapy (oral suspension formulation)","id":"OG000","title":"TMT 0.025 mg/kg/Day + 50% DRB RP2D"},{"description":"Participants treated with a combination therapy of trametinib (0.025 mg/kg/day) plus 100% of the RP2D of dabrafenib monotherapy (oral suspension formulation)","id":"OG001","title":"TMT 0.025 mg/kg/Day + 100% DRB RP2D"},{"description":"Participants treated with a combination therapy of trametinib (0.032 mg/kg/day) plus 100% of the RP2D of dabrafenib monotherapy (oral suspension formulation)","id":"OG002","title":"TMT 0.032 mg/kg/Day + 100% DRB RP2D"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"All subjects who received at least one dose of dabrafenib oral suspension and filled in the palatability questionnaire.\n\nAll palatability questionnaire results were combined and reported based on drug dose to better determine the acceptability and palatability of the formulation. There were no results available for participants who received 50% of the RP2D of dabrafenib monotherapy in combination with trametinib because the participants did not fill in the questionnaire.","reportingStatus":"POSTED","timeFrame":"After the first dose of dabrafenib oral suspension and no later than Day 8 (±3 days)","title":"Palatability of Dabrafenib Oral Suspension in Pediatric Subjects Assessed by Palatability Questionnaire","type":"SECONDARY","unitOfMeasure":"Participants"}