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medicine?"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"7"},{"groupId":"OG003","value":"1"}],"title":"Yes"},{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"19"},{"groupId":"OG002","value":"13"},{"groupId":"OG003","value":"3"}],"title":"No"},{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"}],"title":"missing"}],"title":"Did the subject have difficulty in taking the medicine?"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"title":"Yes"},{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"18"},{"groupId":"OG002","value":"14"},{"groupId":"OG003","value":"3"}],"title":"No"},{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"}],"title":"missing"}],"title":"Did the subject resist taking the medicine?"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"24"},{"groupId":"OG002","value":"20"},{"groupId":"OG003","value":"4"}],"title":"missing"}],"title":"Was the medicine 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sweet?"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"24"},{"groupId":"OG002","value":"20"},{"groupId":"OG003","value":"4"}],"title":"missing"}],"title":"Was the medicine sour?"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"24"},{"groupId":"OG002","value":"20"},{"groupId":"OG003","value":"4"}],"title":"missing"}],"title":"Was the medicine gritty?"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"title":"Yes"},{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"0"}],"title":"No"},{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"23"},{"groupId":"OG002","value":"20"},{"groupId":"OG003","value":"4"}],"title":"missing"}],"title":"Was the medicine difficult to swallow?"}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"21"},{"groupId":"OG003","value":"4"}],"units":"Participants"}],"description":"For subjects ≥ 12 years of age who received the trametinib oral solution, the subject completed a form to evaluate the various properties of the solution (e.g., bitterness, sweetness, appearance, texture and overall taste). For subjects \\< 12 years of age who received the solution, their caregiver (e.g. parent or guardian) evaluated the solution with the child based on verbal and non-verbal feedback. The questionnaire was completed after the first dose of study drug and no later than Day 8 (±3 days). Subjects completed a form for each drug separately if enrolled in Parts C and D.","groups":[{"description":"Participants treated with trametinib oral solution at a dose level of 0.0125 mg/kg/day","id":"OG000","title":"TMT 0.0125 mg/kg/Day"},{"description":"Participants treated with trametinib oral solution at a dose level of 0.025 mg/kg/day","id":"OG001","title":"TMT 0.025 mg/kg/Day"},{"description":"Participants treated with trametinib oral solution at a dose level of 0.032 mg/kg/day","id":"OG002","title":"TMT 0.032 mg/kg/Day"},{"description":"Participants treated with trametinib oral solution at a dose level of 0.04 mg/kg/day","id":"OG003","title":"TMT 0.04 mg/kg/Day"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"All subjects who received at least one dose of trametinib oral solution and filled in the palatability questionnaire.\n\nAll palatability questionnaire results were combined and reported based on drug dose to better determine the acceptability and palatability of the formulation.","reportingStatus":"POSTED","timeFrame":"After the first dose of trametinib oral solution and no later than Day 8 (±3 days)","title":"Palatability of Trametinib Oral Solution in Pediatric Subjects Assessed by Palatability Questionnaire","type":"SECONDARY","unitOfMeasure":"Participants"}