{"analyses":[{"ciLowerLimit":"0.86","ciNumSides":"TWO_SIDED","ciPctValue":"96","ciUpperLimit":"2.29","estimateComment":"Adjusted for initial treatment (primary debulking surgery or neoadjuvant therapy followed by surgery) and planned chemotherapy regimen.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.21","pValueComment":"Two-sided.","paramType":"Hazard Ratio (HR)","paramValue":"1.49","statisticalComment":"Stratified by initial treatment (primary debulking surgery or neoadjuvant therapy followed by surgery) and planned chemotherapy regimen.","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"28.0","upperLimit":"48.2","value":"40.7"},{"groupId":"OG001","lowerLimit":"35.3","upperLimit":"57.2","value":"43.8"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"54"},{"groupId":"OG001","value":"54"}],"units":"Participants"}],"description":"Time from randomization to death.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients receive metformin hydrochloride PO BID and standard chemotherapy for 6 -8 cycles. Treatment with metformin hydrochloride continues for up to 2 years in the absence of disease progression or unacceptable toxicity.\n\nmetformin hydrochloride: Given PO\n\nChemotherapy: Participants will receive standard chemotherapy (6-8 cycles). Specific regimen to be given was chosen from among six protocol-specified options at the discretion of their treating physician.","id":"OG000","title":"Metformin Plus Chemotherapy"},{"description":"Patients receive placebo PO BID and standard chemotherapy for 6 -8 cycles. Treatment with placebo continues for up to 2 years in the absence of disease progression or unacceptable toxicity.\n\nplacebo: Given PO\n\nChemotherapy: Participants will receive standard chemotherapy (6-8 cycles). Specific regimen to be given was chosen from among six protocol-specified options at the discretion of their treating physician.","id":"OG001","title":"Placebo Plus Chemotherapy"}],"paramType":"MEDIAN","reportingStatus":"POSTED","timeFrame":"Up to 6 years","title":"Overall Survival","type":"SECONDARY","unitOfMeasure":"Months"}