{"groups":[{"description":"Investigators choice of Letrozole 2.5 mg po qd continuously, tamoxifen 20mg po bid continuously, paclitaxel 80mg/m2 IV over 1 hr on day 1q 7d, 3 wks on, 1 wk off, Pegylated Liposomal Doxorubicin 40 or 50mg/m2 IV over 1 hr on day 1 q. 28d, Topotecan 4.0mg/m2 over 30 min on day 1,8 and 15 of a 28 day cycle. For each arm, 1 cycle - 28 days","id":"FG000","title":"Arm A - Control Arm"},{"description":"Trametinib 2 mg po daily continuous treatment, For each arm, 1 cycle = 28 days","id":"FG001","title":"Arm B - Experimental Arm"}],"periods":[{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"130"},{"groupId":"FG001","numSubjects":"130"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"88"},{"groupId":"FG001","numSubjects":"0"}],"type":"Crossover from Arm A to Arm B"},{"achievements":[{"groupId":"FG000","numSubjects":"120"},{"groupId":"FG001","numSubjects":"116"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"10"},{"groupId":"FG001","numSubjects":"14"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}],"recruitmentDetails":"A total of 260 patients enrolled before accrual closed on 04/10/2018."}