{"groups":[{"description":"Participants received rituximab 1 gram intravenously (IV) on Days 1 and 15 of each course of retreatment. In addition, participants received methotrexate 10-25 milligrams per week (mg/week) orally or parenterally, methylprednisolone 100 mg IV 30 minutes prior to both rituximab infusions, and a stable dose of folic acid greater than or equal to (\\>=) 5 mg/week or equivalent. Participants received retreatment (next course of rituximab repeat treatment) within 2 weeks of meeting the retreatment criteria as defined in the protocol (minimum of 24 weeks after the first \\[Day 1\\] infusion of the last course of rituximab). Repeat treatment was based on the investigator's decision of prior clinical response to rituximab, clinical need and evidence of active disease (Disease Activity Score in 28 joints \\>=2.6). Retreatment with rituximab was continued until withdrawal of consent or study treatment completion on 31 December 2011, whichever occurred earlier.","id":"FG000","title":"Rituximab"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"26"}],"type":"Adverse Event"},{"reasons":[{"groupId":"FG000","numSubjects":"10"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"157"}],"type":"Other"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"465"}],"type":"STARTED"},{"achievements":[{"comment":"At predefined end-of-treatment date, 272 ongoing participants were designated as completed study.","groupId":"FG000","numSubjects":"272"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"193"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}],"recruitmentDetails":"This study included participants who had previously participated in studies WA16291 (NCT02693210) or WA17043 (NCT00074438)."}