{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"57.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"436"}],"units":"Participants"}],"title":"Moderate: 24 weeks after first course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"58.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"378"}],"units":"Participants"}],"title":"Moderate: 24 weeks after second course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"59.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"299"}],"units":"Participants"}],"title":"Moderate: 24 weeks after third course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"60.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"233"}],"units":"Participants"}],"title":"Moderate: 24 weeks after fourth course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"62.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"169"}],"units":"Participants"}],"title":"Moderate: 24 weeks after fifth course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"57.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"107"}],"units":"Participants"}],"title":"Moderate: 24 weeks after sixth course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"60.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"70"}],"units":"Participants"}],"title":"Moderate: 24 weeks after seventh course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"24.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"436"}],"units":"Participants"}],"title":"Good: 24 weeks after first course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"30.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"378"}],"units":"Participants"}],"title":"Good: 24 weeks after second course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"29.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"299"}],"units":"Participants"}],"title":"Good: 24 weeks after third course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"27.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"233"}],"units":"Participants"}],"title":"Good: 24 weeks after fourth course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"24.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"169"}],"units":"Participants"}],"title":"Good: 24 weeks after fifth course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"27.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"107"}],"units":"Participants"}],"title":"Good: 24 weeks after sixth course"},{"categories":[{"measurements":[{"groupId":"OG000","value":"25.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"70"}],"units":"Participants"}],"title":"Good: 24 weeks after seventh course"}],"denoms":[{"counts":[{"groupId":"OG000","value":"436"}],"units":"Participants"}],"description":"DAS28-ESR was calculated from SJC and TJC using 28 joints count, ESR (mm/hour), and Physician's Global Assessment of Disease Activity (VAS: 0=no disease activity to 100=maximum disease activity). DAS28-ESR = 0.56\\*sqrt(TJC28) + 0.28\\*sqrt(SJC28) + 0.70\\*ln(ESR) + 0.014\\*Patient's Global Assessment of Disease Activity. The DAS28-based EULAR response criteria were used to measure individual response as none, good, and moderate, depending on the extent of change from baseline and the level of disease activity reached. Good responders had a change from baseline greater than (\\>) 1.2 with a DAS28 score less than or equal to (≤) 3.2; moderate responders had a change from baseline \\>1.2 with a DAS28 score \\>3.2 to less than or equal to (≤) 5.1 or a change from baseline \\>0.6 to ≤1.2 with a DAS28 score ≤5.1.","groups":[{"description":"Participants received rituximab 1 gram IV on Days 1 and 15 of each course of retreatment. In addition, participants received methotrexate 10-25 mg/week orally or parenterally, methylprednisolone 100 mg IV 30 minutes prior to both rituximab infusions, and a stable dose of folic acid \\>=5 mg/week or equivalent. Participants received retreatment (next course of rituximab repeat treatment) within 2 weeks of meeting the retreatment criteria as defined in the protocol (minimum of 24 weeks after the first \\[Day 1\\] infusion of the last course of rituximab). Repeat treatment was based on the investigator's decision of prior clinical response to rituximab, clinical need and evidence of active disease (Disease Activity Score in 28 joints \\>=2.6). Retreatment with rituximab was continued until withdrawal of consent or study treatment completion on 31 December 2011, whichever occurred earlier.","id":"OG000","title":"Rituximab"}],"paramType":"NUMBER","populationDescription":"ITT Population. Here, number of participants analyzed = participants who were evaluable for this outcome. Number analyzed = participants who were evaluable for specified category.","reportingStatus":"POSTED","timeFrame":"24 weeks after first, second, third, fourth, fifth, sixth, and seventh course of rituximab (median duration of 26, 90.9, 162.9, 232, 297.3, 354.4, and 406.7 weeks, respectively)","title":"Percentage of Participants With European League Against Rheumatism (EULAR) Response of 'Good' or 'Moderate'","type":"SECONDARY","unitOfMeasure":"percentage of participants"}