{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"64.6","value":"2565.8"},{"groupId":"OG001","spread":"61.7","value":"6493.0"},{"groupId":"OG002","spread":"54.5","value":"7229.3"},{"groupId":"OG003","spread":"32.3","value":"13691.7"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"14"},{"groupId":"OG003","value":"6"}],"units":"Participants"}],"description":"Pharmacokinetics of escalating dose levels of IMO 8400 administered by SC injection - AUC0-t (hr\\*ng/mL) .","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"IMO-8400 0.6 mg/kg once weekly s.c.","id":"OG000","title":"IMO-8400 0.6 mg/kg 1x/wk"},{"description":"IMO-8400 1.2 mg/kg once weekly s.c.","id":"OG001","title":"IMO-8400 1.2 mg/kg 1x/wk"},{"description":"IMO-8400 1.2 mg/kg twice weekly s.c.","id":"OG002","title":"IMO-8400 1.2 mg/kg 2x/wk"},{"description":"IMO-8400 2.4 mg/kg once weekly s.c.","id":"OG003","title":"IMO-8400 2.4 mg/kg 1x/wk"}],"paramType":"GEOMETRIC_MEAN","reportingStatus":"POSTED","timeFrame":"Cycle 1 Week 1 Day 1: Samples were obtained pre-dose (within 1 hr prior to injection) and post-dose at 1 hr (+/-5 min), 2 hrs (+/-10 min) and 4 hrs (+/-15 min)","title":"Pharmacokinetics of Escalating Dose Levels of IMO 8400 Administered by SC Injection - AUC0-t (hr*ng/mL)","type":"SECONDARY","unitOfMeasure":"AUC0-t (hr*ng/mL)"}