{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.83","value":"-0.6"},{"groupId":"OG001","spread":"0.45","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"5"}],"units":"Participants"}],"title":"Day 1 (Cycle 2), n=2,5"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.81","value":"-0.6"},{"groupId":"OG001","spread":"0.23","value":"-0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"}],"units":"Participants"}],"title":"Day 1 (Cycle 3), n=2,4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.79","value":"-0.7"},{"groupId":"OG001","spread":"0.25","value":"-0.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"}],"units":"Participants"}],"title":"Day 1 (Cycle 4), n=2,4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.78","value":"-0.6"},{"groupId":"OG001","spread":"0.46","value":"-0.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"}],"units":"Participants"}],"title":"Day 1 (Cycle 5), n=2,4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.80","value":"-0.6"},{"groupId":"OG001","spread":"0.33","value":"-0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"}],"units":"Participants"}],"title":"Day 1 (Cycle 6), n=2,4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.79","value":"-0.6"},{"groupId":"OG001","spread":"0.48","value":"-0.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"}],"units":"Participants"}],"title":"Day 1 (Cycle 7), n=2,4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.80","value":"-0.6"},{"groupId":"OG001","spread":"0.15","value":"0.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 8), n=2,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.1"},{"groupId":"OG001","spread":"0.33","value":"0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 9), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.1"},{"groupId":"OG001","spread":"0.03","value":"-0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 10), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.2"},{"groupId":"OG001","spread":"0.06","value":"-0.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 11), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.2"},{"groupId":"OG001","spread":"0.13","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 12), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.1"},{"groupId":"OG001","spread":"0.09","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 13), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.0"},{"groupId":"OG001","spread":"0.11","value":"0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 14), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.1"},{"groupId":"OG001","spread":"0.10","value":"0.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 15), n=1,2"},{"categories":[{"measurements":[{"comment":"NA indicates that standard deviation could not be calculated for a single participant.","groupId":"OG000","spread":"NA","value":"-1.2"},{"groupId":"OG001","spread":"0.11","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"Day 1 (Cycle 16), n=1,2"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"description":"Urine samples were collected to assess urine Pro. Baseline was the latest pre-dose assessment with a non-missing value, including unscheduled visits. Change from Baseline was calculated by subtracting Baseline value from the post-dose visit value. Data for change from Baseline in urine Pro. excretion (24 hour) is presented","dispersionType":"Standard Deviation","groups":[{"description":"Participants were administered a dose of 3.40 mg/kg GSK2857916 as IV infusion once every three weeks for a maximum of 16 cycles (1 cycle= 21 days).","id":"OG000","title":"Part 1: GSK2857916 3.40 mg/kg"},{"description":"Participants were administered a dose of 4.60 mg/kg GSK2857916 as IV infusion once every three weeks for a maximum of 16 cycles (1 cycle= 21 days).","id":"OG001","title":"Part 1: GSK2857916 4.60 mg/kg"}],"paramType":"MEAN","populationDescription":"Part 1 Population. Only those participants with data available at the specified data points were analyzed (represented by n=X in the category titles). NA indicates that standard deviation could not be calculated for a single participant.","reportingStatus":"POSTED","timeFrame":"Baseline and Day 1 (Cycle 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)","title":"Change From Baseline in Urine Protein Excretion (24 Hour)-Part 1: GSK2857916 3.40 mg/kg and 4.60 mg/kg","type":"PRIMARY","unitOfMeasure":"Grams per day"}