{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Gl, Hyperglycemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Gl, Hyperglycemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Gl, Hyperglycemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Gl, Hypoglycemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Gl, Hypoglycemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Gl, Hypoglycemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Albumin,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Albumin,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Albumin,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"ALP,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALP,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALP,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"ALT,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALT,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"ALT,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"AST,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"AST,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"AST,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Total bilirubin,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Total bilirubin,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Total bilirubin,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"CK,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"CK,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"CK,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Creatinine,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatinine,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Creatinine,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"GGT,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"GGT,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"GGT,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Pot,Hyperkalemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Pot,Hyperkalemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Pot,Hyperkalemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Pot,Hypokalemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Pot,Hypokalemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Pot,Hypokalemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Mg,Hypermagnesemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Mg,Hypermagnesemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Mg,Hypermagnesemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Mg,Hypomagnesemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Mg,Hypomagnesemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Mg,Hypomagnesemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"}]}],"title":"Phosphate,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Phosphate,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Phosphate,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sod,Hypernatremia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sod,Hypernatremia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sod,Hypernatremia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"}]}],"title":"Sod,Hyponatremia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sod,Hyponatremia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Sod,Hyponatremia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"}]}],"title":"Ca,Hypercalcemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Ca,Hypercalcemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Ca,Hypercalcemia,increase to Grade 4"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Ca,Hypocalcemia,any grade increase"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Ca,Hypocalcemia,increase to Grade 3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"Ca,Hypocalcemia,increase to Grade 4"}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"}],"units":"Participants"}],"description":"Blood samples were collected for the analysis of following clinical chemistry parameters: albumin, ALP, ALT, AST, Bilirubin, Ca, Creat, CK, GGT, Glucose, Pot, Mg, Sod, and Ph. Values(Hyper and hypo)for Glucose, Pot, Mg, Sod and Ca is presented. Laboratory parameters were graded according to NCI-CTCAE version 4.0. Grade 1: mild; Grade 2: moderate; Grade 3: severe or medically significant; Grade 4: life-threatening consequences; Grade 5: death related to AE. All increases are an increase in grade from Baseline. Baseline was the latest pre-dose assessment with a non-missing value, including unscheduled visits. Data for worst-case post Baseline is presented.","groups":[{"description":"Participants with non-hodgkin's lymphoma were administered a dose of 3.40 mg/kg GSK2857916 as IV infusion once every three weeks for a maximum of 36 cycles (1 cycle=21 days).","id":"OG000","title":"Part 2: GSK2857916 3.40 mg/kg (NHL)"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Part 2 NHL Population. Only those participants with data available at the specified data points were analyzed.","reportingStatus":"POSTED","timeFrame":"Baseline and Up to 7.2 months (maximum duration of follow-up from first dose to last contact or death)","title":"Number of Participants With Grade Change From Baseline in Clinical Chemistry Data-Part 2 (NHL)","type":"PRIMARY","unitOfMeasure":"Participants"}