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In the absence of disease progression, patients may continue ibrutinib PO QD.","id":"EG000","otherNumAffected":348,"otherNumAtRisk":352,"seriousNumAffected":270,"seriousNumAtRisk":352,"title":"Arm A (Ibrutinib, Rituximab)"},{"deathsNumAffected":10,"deathsNumAtRisk":175,"description":"Patients receive rituximab IV over 4 hours on days 1 (50 mg/m2) and 2 (325 mg/m2) of cycle 1, and day 1 (500 mg/m2) of cycles 2-6. Patients also receive fludarabine phosphate at 25 mg/m2 IV over 30 minutes and cyclophosphamide at 250 mg/m2 IV over 30 minutes on days 1-3. Treatment repeats every 28 days for 6 cycles in the absence of unacceptable toxicity.","id":"EG001","otherNumAffected":154,"otherNumAtRisk":158,"seriousNumAffected":132,"seriousNumAtRisk":158,"title":"Arm B (Rituximab, Fludarabine Phosphate, Cyclophosphamide)"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"CTCAE 4.0","stats":[{"groupId":"EG000","numAffected":183,"numAtRisk":352},{"groupId":"EG001","numAffected":99,"numAtRisk":158}],"term":"Anemia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE 4.0","stats":[{"groupId":"EG000","numAffected":27,"numAtRisk":352},{"groupId":"EG001","numAffected":0,"numAtRisk":158}],"term":"Atrial fibrillation"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Cardiac disorders","sourceVocabulary":"CTCAE 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