{"eventGroups":[{"deathsNumAffected":0,"deathsNumAtRisk":10,"description":"Defactinib 400 mg BID for 12 days","id":"EG000","otherNumAffected":7,"otherNumAtRisk":10,"seriousNumAffected":1,"seriousNumAtRisk":10,"title":"Cohort 1"},{"deathsNumAffected":1,"deathsNumAtRisk":10,"description":"Defactinib 400 mg BID for 35 days","id":"EG001","otherNumAffected":8,"otherNumAtRisk":10,"seriousNumAffected":2,"seriousNumAtRisk":10,"title":"Cohort 2"},{"deathsNumAffected":1,"deathsNumAtRisk":10,"description":"Defactinib 400 mg BID for 21 days","id":"EG002","otherNumAffected":6,"otherNumAtRisk":10,"seriousNumAffected":2,"seriousNumAtRisk":10,"title":"Cohort 3"},{"deathsNumAffected":0,"deathsNumAtRisk":5,"description":"Defactinib 100 mg BID for 21 days","id":"EG003","otherNumAffected":2,"otherNumAtRisk":5,"seriousNumAffected":2,"seriousNumAtRisk":5,"title":"Cohort 4"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Abdominal distension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Constipation"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":4,"numAtRisk":10,"numEvents":4},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Diarrhea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":3,"numAtRisk":10,"numEvents":4},{"groupId":"EG002","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Nausea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Abdominal pain upper"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":3,"numAtRisk":10,"numEvents":5},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Vomiting"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":4,"numAtRisk":10,"numEvents":4},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Fatigue"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Pyrexia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Hepatobiliary disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":10,"numEvents":4},{"groupId":"EG001","numAffected":3,"numAtRisk":10,"numEvents":6},{"groupId":"EG002","numAffected":3,"numAtRisk":10,"numEvents":3},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Hyperbilirubinaemia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Upper Respiratory Infection"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":2,"numAtRisk":10,"numEvents":3},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"International normalised ratio increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Weight decreased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Back Pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Musculoskeletal chest pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Musculoskeletal and connective tissue disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Arthralgia"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Neoplasms benign, malignant and unspecified (incl cysts and polyps)","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":3},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Tumor Pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":3},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":2,"numAtRisk":5,"numEvents":2}],"term":"Headache"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Nervous system disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Tremor"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":6,"numAtRisk":10,"numEvents":6},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Cough"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":8,"numAtRisk":10,"numEvents":8},{"groupId":"EG002","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Dyspnea"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Nasal Congestion"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Productive Cough"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Oropharyngeal pain"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Skin and subcutaneous tissue disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":3,"numAtRisk":10,"numEvents":3},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Night Sweats"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":2},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Hypertension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Vascular disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Hypotension"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Injury, poisoning and procedural complications","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":2,"numAtRisk":10,"numEvents":5},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Injury, poisoning, procedureal complications"}],"seriousEvents":[{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Investigations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"International Normalised Ratio increased"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"General disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Disease progression"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Infections and infestations","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Wound Infection"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Neoplasms benign, malignant and unspecified (incl cysts and polyps)","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Metastases to central nervous system"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":1,"numAtRisk":10,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":5,"numEvents":0}],"term":"Disseminated intravascular coagulation"},{"assessmentType":"NON_SYSTEMATIC_ASSESSMENT","organSystem":"Gastrointestinal disorders","sourceVocabulary":"MedDRA (Unspecified)","stats":[{"groupId":"EG000","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG001","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG002","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG003","numAffected":1,"numAtRisk":5,"numEvents":1}],"term":"Abdominal hernia"}],"timeFrame":"Cohort 1, 40 days Cohort 2, 42 days Cohort 3, 28 days Cohort 4, 28 days"}