{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"578"},{"groupId":"OG001","value":"298"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"884"},{"groupId":"OG001","value":"439"}],"units":"Participants"}],"title":"Baseline-No problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"183"},{"groupId":"OG001","value":"100"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"884"},{"groupId":"OG001","value":"439"}],"units":"Participants"}],"title":"Baseline-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"33"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"884"},{"groupId":"OG001","value":"439"}],"units":"Participants"}],"title":"Baseline-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"884"},{"groupId":"OG001","value":"439"}],"units":"Participants"}],"title":"Baseline-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"884"},{"groupId":"OG001","value":"439"}],"units":"Participants"}],"title":"Baseline-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"526"},{"groupId":"OG001","value":"274"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"840"},{"groupId":"OG001","value":"419"}],"units":"Participants"}],"title":"Week 17-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"190"},{"groupId":"OG001","value":"88"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"840"},{"groupId":"OG001","value":"419"}],"units":"Participants"}],"title":"Week 17-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"87"},{"groupId":"OG001","value":"50"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"840"},{"groupId":"OG001","value":"419"}],"units":"Participants"}],"title":"Week 17-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"840"},{"groupId":"OG001","value":"419"}],"units":"Participants"}],"title":"Week 17-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"840"},{"groupId":"OG001","value":"419"}],"units":"Participants"}],"title":"Week 17-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"431"},{"groupId":"OG001","value":"223"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"738"},{"groupId":"OG001","value":"342"}],"units":"Participants"}],"title":"Week 33-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"162"},{"groupId":"OG001","value":"85"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"738"},{"groupId":"OG001","value":"342"}],"units":"Participants"}],"title":"Week 33-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"103"},{"groupId":"OG001","value":"24"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"738"},{"groupId":"OG001","value":"342"}],"units":"Participants"}],"title":"Week 33-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"36"},{"groupId":"OG001","value":"10"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"738"},{"groupId":"OG001","value":"342"}],"units":"Participants"}],"title":"Week 33-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"738"},{"groupId":"OG001","value":"342"}],"units":"Participants"}],"title":"Week 33-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"362"},{"groupId":"OG001","value":"156"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"635"},{"groupId":"OG001","value":"250"}],"units":"Participants"}],"title":"Week 49-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"158"},{"groupId":"OG001","value":"57"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"635"},{"groupId":"OG001","value":"250"}],"units":"Participants"}],"title":"Week 49-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"86"},{"groupId":"OG001","value":"27"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"635"},{"groupId":"OG001","value":"250"}],"units":"Participants"}],"title":"Week 49-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"25"},{"groupId":"OG001","value":"8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"635"},{"groupId":"OG001","value":"250"}],"units":"Participants"}],"title":"Week 49-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"635"},{"groupId":"OG001","value":"250"}],"units":"Participants"}],"title":"Week 49-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"319"},{"groupId":"OG001","value":"121"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"536"},{"groupId":"OG001","value":"193"}],"units":"Participants"}],"title":"Week 65-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"109"},{"groupId":"OG001","value":"44"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"536"},{"groupId":"OG001","value":"193"}],"units":"Participants"}],"title":"Week 65-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"75"},{"groupId":"OG001","value":"22"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"536"},{"groupId":"OG001","value":"193"}],"units":"Participants"}],"title":"Week 65-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"536"},{"groupId":"OG001","value":"193"}],"units":"Participants"}],"title":"Week 65-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"536"},{"groupId":"OG001","value":"193"}],"units":"Participants"}],"title":"Week 65-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"236"},{"groupId":"OG001","value":"88"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"435"},{"groupId":"OG001","value":"148"}],"units":"Participants"}],"title":"Week 81-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"111"},{"groupId":"OG001","value":"39"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"435"},{"groupId":"OG001","value":"148"}],"units":"Participants"}],"title":"Week 81-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"61"},{"groupId":"OG001","value":"15"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"435"},{"groupId":"OG001","value":"148"}],"units":"Participants"}],"title":"Week 81-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"435"},{"groupId":"OG001","value":"148"}],"units":"Participants"}],"title":"Week 81-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"435"},{"groupId":"OG001","value":"148"}],"units":"Participants"}],"title":"Week 81-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"189"},{"groupId":"OG001","value":"59"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"365"},{"groupId":"OG001","value":"95"}],"units":"Participants"}],"title":"Week 97-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"94"},{"groupId":"OG001","value":"24"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"365"},{"groupId":"OG001","value":"95"}],"units":"Participants"}],"title":"Week 97-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"54"},{"groupId":"OG001","value":"8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"365"},{"groupId":"OG001","value":"95"}],"units":"Participants"}],"title":"Week 97-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"365"},{"groupId":"OG001","value":"95"}],"units":"Participants"}],"title":"Week 97-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"365"},{"groupId":"OG001","value":"95"}],"units":"Participants"}],"title":"Week 97-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"140"},{"groupId":"OG001","value":"45"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"275"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Week 113-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"14"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"275"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Week 113-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"41"},{"groupId":"OG001","value":"11"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"275"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Week 113-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"275"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Week 113-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"275"},{"groupId":"OG001","value":"73"}],"units":"Participants"}],"title":"Week 113-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"94"},{"groupId":"OG001","value":"26"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"193"},{"groupId":"OG001","value":"41"}],"units":"Participants"}],"title":"Week 129-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"48"},{"groupId":"OG001","value":"9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"193"},{"groupId":"OG001","value":"41"}],"units":"Participants"}],"title":"Week 129-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"36"},{"groupId":"OG001","value":"5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"193"},{"groupId":"OG001","value":"41"}],"units":"Participants"}],"title":"Week 129-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"15"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"193"},{"groupId":"OG001","value":"41"}],"units":"Participants"}],"title":"Week 129-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"193"},{"groupId":"OG001","value":"41"}],"units":"Participants"}],"title":"Week 129-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"56"},{"groupId":"OG001","value":"13"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"116"},{"groupId":"OG001","value":"21"}],"units":"Participants"}],"title":"Week 145-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"35"},{"groupId":"OG001","value":"5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"116"},{"groupId":"OG001","value":"21"}],"units":"Participants"}],"title":"Week 145-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"18"},{"groupId":"OG001","value":"2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"116"},{"groupId":"OG001","value":"21"}],"units":"Participants"}],"title":"Week 145-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"116"},{"groupId":"OG001","value":"21"}],"units":"Participants"}],"title":"Week 145-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"116"},{"groupId":"OG001","value":"21"}],"units":"Participants"}],"title":"Week 145-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"Week 161-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"Week 161-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"Week 161-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"Week 161-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"Week 161-unable to walk"},{"categories":[{"measurements":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"title":"Week 177-no problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"title":"Week 177-slight problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"title":"Week 177-moderate problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"title":"Week 177-severe problem in walking"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"title":"Week 177-unable to walk"}],"denoms":[{"counts":[{"groupId":"OG000","value":"933"},{"groupId":"OG001","value":"468"}],"units":"Participants"}],"description":"EQ-5D-5L is a standardized instrument that measures health-related quality of life for men with prostate cancer. EQ-5D consists of EQ-5D descriptive system and EQ visual analogue scale (VAS). EQ-5D descriptive system comprises of 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Each dimension has 5 levels: 1=no problems, 2=slight problems, 3=moderate problems, 4=severe problems, and 5=extreme problems. Number of participants with various responses to the mobility questionnaire are reported.","groups":[{"description":"Participants received 4 capsules of Enzalutamide 40 mg each (total dose 160 mg per day) orally, once daily in double-blind and open-label phase (up to a maximum of 68.8 months) until radiographic progression. Participants after last dose of study drug, were followed up for safety up to 30 days, and were long term followed up (for survival status and new prostate cancer therapies) from last dose to the death date or last known survival date.","id":"OG000","title":"Enzalutamide 160 mg"},{"description":"Participants received 4 capsules of placebo (matched to Enzalutamide) orally, once daily in double blind phase (up to a maximum of 51.3 months) until radiographic progression. Participants were given an opportunity to switch to open-label enzalutamide after completion of double blind phase. Participants after last dose of study drug, were followed up for safety up to 30 days and were long term followed up (for survival status and new prostate cancer therapies) to the death date or last known survival date.","id":"OG001","title":"Placebo"}],"paramType":"NUMBER","populationDescription":"The ITT population was defined as all participants randomly assigned to study treatment and was based on randomized treatment assignment regardless of whether or not treatment was administered. Here, 'Number analyzed' = Participants evaluable for this outcome measure for specified categories.","reportingStatus":"POSTED","timeFrame":"Baseline, Weeks 17, 33, 49, 65, 81, 97, 113, 129, 145,161 and 177","title":"Number of Participants With European Quality of Life-5 Dimensions-5 Levels (EQ-5D-5L) Mobility Domain Score","type":"SECONDARY","unitOfMeasure":"participants"}