{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"3","upperLimit":"63","value":"31"},{"groupId":"OG001","lowerLimit":"12","upperLimit":"85","value":"54"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"15"}],"units":"Participants"}],"description":"Median profression free survival.","dispersionType":"Full Range","groups":[{"description":"This is a prospective, two-arm phase I randomized trial. Patients will be accrued only from and treated at MSKCCand The Rockefeller University/Center for Clinical \\& Translational Science . The study will assess autologous LCs presenting CT7, MAGE-A3, and WT1 after electroporation with CT7, MAGE-A3, and WT1 mRNA. Twenty patients will accrue to the study and ten will receive vaccines at 9x10\\^6 LCs per dose (i.e., combination of 3x10\\^6 CT7 mRNA-electroporated LCs + 3x10\\^6 MAGE-A3 mRNA-electroporated LCs + 3x10\\^6 WT1 mRNA-electroporated LCs) and another ten who will not receive any LC vaccines but will otherwise undergo identical cytoreduction, ASCT, and standard supportive care. At approximately 3 months after ASCT and as deemed clinically appropriate, patients will start lenalidomide maintenance therapy, which is now standard to delay disease progression.\n\nCT7, MAGE-A3, and WT1 mRNA-electroporated Langerhans cells ( LCs): Patients receive CT7/MAGE-A3/WT1 mRNA-electroporated autologous Langerhans-type dendritic cells ID on days 12, 30, and 90 after autologous stem cell transplant. Patients on the vaccine arm of the study will receive a total of 3 vaccinations, comprising a primary immunization on day +12 after ASCT followed by two boosters at days +30 and +90. Vaccines will be dosed at 9x10\\^6 LCs per vaccine x 3.","id":"OG000","title":"Arm 1 Vaccine"},{"description":"Patients receive standard of care treatment after autologous stem cell transplant\n\nStandard of care: No vaccines","id":"OG001","title":"Arm 2 Control"}],"paramType":"MEDIAN","reportingStatus":"POSTED","timeFrame":"Up to 7 years","title":"Median Progression Free Survival","type":"SECONDARY","unitOfMeasure":"months"}