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Patients also receive cyclophosphamide IV over 15-30 minutes on days 1-5 and doxorubicin hydrochloride IV over 1-15 minutes on days 4 and 5.\n\nBrentuximab Vedotin: Given IV\n\nCyclophosphamide: Given IV\n\nCytarabine: Given IT and IV\n\nDexamethasone: Given PO or IV\n\nDoxorubicin Hydrochloride: Given IV\n\nEtoposide: Given IV\n\nIfosfamide: Given IV\n\nMethotrexate: Given IT and IV","id":"BG000","title":"Arm BV (Brentuximab Vedotin, Combination Chemotherapy)"},{"description":"COURSE A (CYCLES 1, 3, AND 5): Patients receive crizotinib PO BID on days 1-21 and dexamethasone, ifosfamide, methotrexate, cytarabine, and etoposide as in Arm BV, Course A.\n\nCOURSE B (CYCLES 2, 4, AND 6): Patients receive crizotinib as in Arm CZ, Course A and dexamethasone, cyclophosphamide, methotrexate, and doxorubicin hydrochloride as in Arm BV, Course B.\n\nCrizotinib: Given PO\n\nCyclophosphamide: Given IV\n\nCytarabine: Given IT and IV\n\nDexamethasone: Given PO or IV\n\nDoxorubicin Hydrochloride: Given IV\n\nEtoposide: Given IV\n\nIfosfamide: Given IV\n\nMethotrexate: Given IT and IV","id":"BG001","title":"Arm CZ (Crizotinib, Combination Chemotherapy)"},{"description":"Total of all reporting groups","id":"BG002","title":"Total"}],"measures":[{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"64"},{"groupId":"BG001","value":"65"},{"groupId":"BG002","value":"129"}],"title":"<=18 years"},{"measurements":[{"groupId":"BG000","value":"4"},{"groupId":"BG001","value":"4"},{"groupId":"BG002","value":"8"}],"title":"Between 18 and 65 years"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":">=65 years"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Age, Categorical","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","spread":"4.9","value":"10.8"},{"groupId":"BG001","spread":"3.3","value":"13.6"},{"groupId":"BG002","spread":"4.4","value":"12.2"}]}]}],"dispersionType":"STANDARD_DEVIATION","paramType":"MEAN","title":"Age, Continuous","unitOfMeasure":"years"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"25"},{"groupId":"BG001","value":"22"},{"groupId":"BG002","value":"47"}],"title":"Female"},{"measurements":[{"groupId":"BG000","value":"43"},{"groupId":"BG001","value":"47"},{"groupId":"BG002","value":"90"}],"title":"Male"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Sex: Female, Male","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"10"},{"groupId":"BG002","value":"15"}],"title":"Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"60"},{"groupId":"BG001","value":"56"},{"groupId":"BG002","value":"116"}],"title":"Not Hispanic or Latino"},{"measurements":[{"groupId":"BG000","value":"3"},{"groupId":"BG001","value":"3"},{"groupId":"BG002","value":"6"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Ethnicity (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"1"}],"title":"American Indian or Alaska Native"},{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"4"},{"groupId":"BG002","value":"9"}],"title":"Asian"},{"measurements":[{"groupId":"BG000","value":"0"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"0"}],"title":"Native Hawaiian or Other Pacific Islander"},{"measurements":[{"groupId":"BG000","value":"8"},{"groupId":"BG001","value":"14"},{"groupId":"BG002","value":"22"}],"title":"Black or African American"},{"measurements":[{"groupId":"BG000","value":"48"},{"groupId":"BG001","value":"46"},{"groupId":"BG002","value":"94"}],"title":"White"},{"measurements":[{"groupId":"BG000","value":"1"},{"groupId":"BG001","value":"0"},{"groupId":"BG002","value":"1"}],"title":"More than one race"},{"measurements":[{"groupId":"BG000","value":"5"},{"groupId":"BG001","value":"5"},{"groupId":"BG002","value":"10"}],"title":"Unknown or Not Reported"}]}],"paramType":"COUNT_OF_PARTICIPANTS","title":"Race (NIH/OMB)","unitOfMeasure":"Participants"},{"classes":[{"categories":[{"measurements":[{"groupId":"BG000","value":"68"},{"groupId":"BG001","value":"69"},{"groupId":"BG002","value":"137"}]}],"title":"United States"}],"paramType":"NUMBER","title":"Region of Enrollment","unitOfMeasure":"participants"}]}