{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"0.179"}]}],"title":"CNS progression"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.325"}]}],"title":"Non CNS progression"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0.055"}]}],"title":"Death"}],"denoms":[{"counts":[{"groupId":"OG000","value":"274"}],"units":"Participants"}],"description":"Probability of first event being CNS progression, non-CNS progression, or death was evaluated with competing risk approach by estimating cumulative incidence functions (range: 0-1) relative to analysis set. Time to first event being Competing Event (either \"CNS progression\" or \"non CNS progression\" or \"Death\") = time from first dose until date of that specific event. Participants not known to have any of Competing Events were censored on date they were last assessed for disease status for PFS. Participants who presented one type of event were counted as competing cause of failure for analysis of other type of events. For each type of event, cumulative incidence function corresponding to nearest time point preceding 1 year is presented. PD:20% or more increase in SLD of target lesion relative to baseline or smallest SLD (nadir) recorded since first dose. SLD must demonstrate absolute increase of atleast 5mm(\\>=5 mm) relative to baseline or smallest SLD (nadir) recorded since first dose.","groups":[{"description":"This reporting group includes all Phase 2 participants in the ITT analysis set.","id":"OG000","title":"Phase 2 ITT Population"}],"paramType":"NUMBER","populationDescription":"The ITT analysis set included all enrolled participants with documented ALK or ROS1 rearrangement who received at least 1 dose of PF-06463922.","reportingStatus":"POSTED","timeFrame":"From first dose of study treatment until first event of CNS progression (maximum of 7.5 years for Phase 2)","title":"Probability of First Event Being a Central Nervous System (CNS) Progression, Non CNS Progression, or Death (Phase 2)","type":"SECONDARY","unitOfMeasure":"Probability of events"}