{"classes":[{"categories":[{"measurements":[{"comment":"None of the participants had data above LLQ and as per the predefined protocol results were to be summarized only for observations above LLQ, hence, data was not reported.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"None of the participants had data above LLQ and as per the predefined protocol results were to be summarized only for observations above LLQ, hence, data was not reported.","groupId":"OG001","spread":"NA","value":"NA"}]}],"title":"Cycle 1, Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11904.18494","value":"30874.4957"},{"groupId":"OG001","spread":"9956.67036","value":"30884.9074"}]}],"title":"Cycle 1, 0.5 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9365.88746","value":"28577.3869"},{"groupId":"OG001","spread":"8192.50406","value":"28865.4674"}]}],"title":"Cycle 1, 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4973.74692","value":"9931.2943"},{"groupId":"OG001","spread":"4396.55604","value":"11626.2147"}]}],"title":"Cycle 1, 72 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1831.73997","value":"2898.2924"},{"groupId":"OG001","spread":"1017.84204","value":"3066.5859"}]}],"title":"Cycle 1, 336 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10312.91280","value":"2055.3871"},{"groupId":"OG001","spread":"904.27346","value":"1363.8319"}]}],"title":"Cycle 2, Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17543.51968","value":"17378.2105"},{"groupId":"OG001","spread":"7742.69918","value":"31583.7793"}]}],"title":"Cycle 2, 0.5 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1592.89993","value":"1361.3147"},{"groupId":"OG001","spread":"1200.68646","value":"1517.6506"}]}],"title":"Cycle 3, Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12467.10368","value":"15974.3723"},{"groupId":"OG001","spread":"10595.70675","value":"33892.4731"}]}],"title":"Cycle 3, 0.5 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14719.69968","value":"11609.1430"},{"groupId":"OG001","spread":"7219.71925","value":"27548.1773"}]}],"title":"Cycle 3, 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7492.70742","value":"13594.2016"},{"groupId":"OG001","spread":"5665.38218","value":"9588.9374"}]}],"title":"Cycle 3, 72 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3000.22116","value":"3206.6925"},{"groupId":"OG001","spread":"1802.66091","value":"3628.9175"}]}],"title":"Cycle 3, 336 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"2024.17213","value":"1329.0886"},{"groupId":"OG001","spread":"1326.12113","value":"1866.5746"}]}],"title":"Cycle 3, 480 hour"}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"description":"The LLQ for all the observations was 12.5 ng/mL.","dispersionType":"Standard Deviation","groups":[{"description":"Brentuximab vedotin 1.8 mg/kg, injection, intravenously, every 3 weeks on Day 1 of each 21-day treatment cycle up to a maximum of 16 brentuximab vedotin doses.","id":"OG000","title":"Brentuximab Vedotin"},{"description":"Brentuximab vedotin 1.8 mg/kg, injection, intravenously, every 3 weeks on Day 1 of each 21-day treatment cycle up to a maximum of 16 brentuximab vedotin doses and rifampicin, 600 mg, capsules, orally, once daily from Day 1 of treatment Cycle 0 through Day 21 of treatment cycle 3.","id":"OG001","title":"Brentuximab Vedotin + Rifampicin"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK analysis set included all participants who received brentuximab vedotin at 1.8 mg/kg throughout Cycles 1 to 3 and had sufficient dosing and PK data to reliably estimate PK parameters.","reportingStatus":"POSTED","timeFrame":"Cycle 1 and 3: Predose, 0.5, 4, 72, 336 hours post-dose; Cycle 2: Predose, 0.5 hours post-dose; Cycle 3: 480 hours post-dose","title":"Serum Concentration of Total Antibody (TAb)","type":"SECONDARY","unitOfMeasure":"ng/mL"}