{"classes":[{"categories":[{"measurements":[{"comment":"None of the participants had data above LLQ and as per the predefined protocol results were to be summarized only for observations above LLQ, hence, data was not reported.","groupId":"OG000","spread":"NA","value":"NA"},{"comment":"None of the participants had data above LLQ and as per the predefined protocol results were to be summarized only for observations above LLQ, hence, data was not reported.","groupId":"OG001","spread":"NA","value":"NA"}]}],"title":"Cycle 1, Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11865.35702","value":"29609.7759"},{"groupId":"OG001","spread":"10398.79403","value":"33125.0025"}]}],"title":"Cycle 1, 0.5 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8092.41448","value":"24398.6482"},{"groupId":"OG001","spread":"6767.70744","value":"24533.2372"}]}],"title":"Cycle 1, 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"2880.39660","value":"4265.7542"},{"groupId":"OG001","spread":"1788.56378","value":"5958.0569"}]}],"title":"Cycle 1, 72 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"740.05650","value":"1167.0713"},{"groupId":"OG001","spread":"376.81123","value":"1108.6515"}]}],"title":"Cycle 1, 336 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10732.46886","value":"794.3851"},{"groupId":"OG001","spread":"303.25245","value":"435.1550"}]}],"title":"Cycle 2, Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15714.59821","value":"16032.6494"},{"groupId":"OG001","spread":"6716.71906","value":"31627.2566"}]}],"title":"Cycle 2, 0.5 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"786.52082","value":"611.0573"},{"groupId":"OG001","spread":"524.72923","value":"536.3692"}]}],"title":"Cycle 3, Predose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12662.05087","value":"20991.9618"},{"groupId":"OG001","spread":"6295.45517","value":"33040.2245"}]}],"title":"Cycle 3, 0.5 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9550.99903","value":"15378.8274"},{"groupId":"OG001","spread":"4212.84997","value":"24496.7203"}]}],"title":"Cycle 3, 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3358.78504","value":"3258.7237"},{"groupId":"OG001","spread":"2431.24647","value":"4262.0364"}]}],"title":"Cycle 3, 72 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1224.66857","value":"1381.2290"},{"groupId":"OG001","spread":"789.04877","value":"1363.9488"}]}],"title":"Cycle 3, 336 hour"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"1065.26404","value":"648.2492"},{"groupId":"OG001","spread":"634.23889","value":"734.5557"}]}],"title":"Cycle 3, 480 hour"}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"description":"The LLQ for all the observations was 12.5 ng/mL.","dispersionType":"Standard Deviation","groups":[{"description":"Brentuximab vedotin 1.8 mg/kg, injection, intravenously, every 3 weeks on Day 1 of each 21-day treatment cycle up to a maximum of 16 brentuximab vedotin doses.","id":"OG000","title":"Brentuximab Vedotin"},{"description":"Brentuximab vedotin 1.8 mg/kg, injection, intravenously, every 3 weeks on Day 1 of each 21-day treatment cycle up to a maximum of 16 brentuximab vedotin doses and rifampicin, 600 mg, capsules, orally, once daily from Day 1 of treatment Cycle 0 through Day 21 of treatment cycle 3.","id":"OG001","title":"Brentuximab Vedotin + Rifampicin"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK analysis set included all participants who received brentuximab vedotin at 1.8 mg/kg throughout Cycles 1 to 3 and had sufficient dosing and PK data to reliably estimate PK parameters.","reportingStatus":"POSTED","timeFrame":"Cycle 1 and 3: Predose, 0.5, 4, 72, 336 hours post-dose; Cycle 2: Predose, 0.5 hours post-dose; Cycle 3: 480 hours post-dose","title":"Serum Concentrations of Antibody-drug Conjugate (ADC)","type":"SECONDARY","unitOfMeasure":"ng/mL"}