{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.467","upperLimit":"1.00","value":"0.617"},{"groupId":"OG001","lowerLimit":"0.467","upperLimit":"0.917","value":"0.600"}]}],"title":"Cycle 1, Day 16 (n = 13, 9)"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.250","upperLimit":"0.617","value":"0.525"},{"groupId":"OG001","lowerLimit":"0.467","upperLimit":"0.750","value":"0.533"}]}],"title":"Cycle 2, Day 1 (n = 10, 8)"}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"dispersionType":"Full Range","groups":[{"description":"Participants with normal renal function received carfilzomib 20 mg/m² IV on days 1 and 2 of cycle 1, followed by 27 mg/m² IV on days 8, 9, 15, and 16 of cycle 1. Participants who adequately tolerated dosing at 27 mg/m² received carfilzomib 56 mg/m² IV on days 1, 2, 8, 9, 15 and 16 of cycle 2 and all subsequent cycles.","id":"OG000","title":"Normal Renal Function"},{"description":"Participants with ESRD received carfilzomib 20 mg/m² IV on days 1 and 2 of cycle 1, followed by 27 mg/m² IV on days 8, 9, 15, and 16 of cycle 1. Participants who adequately tolerated dosing at 27 mg/m² received carfilzomib 56 mg/m² IV on days 1, 2, 8, 9, 15 and 16 of cycle 2 and all subsequent cycles.","id":"OG001","title":"End Stage Renal Disease"}],"paramType":"MEDIAN","populationDescription":"PK evaluable population; one participant was excluded due to samples taken from the infusion arm, distal to the infusion site.","reportingStatus":"POSTED","timeFrame":"Cycle 1, day 16 and cycle 2, day 1 at predose, 15 minutes post start of infusion, immediately before the end of infusion, and at 5, 15, and 30 minutes, and 1, 2, and 4 hours after the end of the infusion.","title":"Time to Maximum Observed Plasma Concentration (Tmax) for Metabolite PR-519/M16","type":"SECONDARY","unitOfMeasure":"hours"}