{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"488.66","value":"501.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"68"}],"units":"Participants"}],"title":"Baseline"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"100.69","value":"217.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"}],"units":"Participants"}],"title":"Core Week 2 n-8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"203.47","value":"242.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"59"}],"units":"Participants"}],"title":"Core Week 4 n=59"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"195.21","value":"230.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"58"}],"units":"Participants"}],"title":"Core Week 8 n=58"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"240.98","value":"231.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"51"}],"units":"Participants"}],"title":"Core Week 13 n=51"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"429.64","value":"310.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"57"}],"units":"Participants"}],"title":"Core Week 17 n=57"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"202.80","value":"214.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"50"}],"units":"Participants"}],"title":"Core Week 22 n=50"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"173.58","value":"211.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"54"}],"units":"Participants"}],"title":"Core Week 26 n=54"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"104.16","value":"154.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"}],"units":"Participants"}],"title":"Core Week 31 n=46"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"140.13","value":"184.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"45"}],"units":"Participants"}],"title":"Core Week 35 n=45"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"91.13","value":"136.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"}],"units":"Participants"}],"title":"Ext Week 43 n=22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"108.91","value":"156.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"}],"units":"Participants"}],"title":"Ext Week 51 n=20"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"111.63","value":"157.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"}],"units":"Participants"}],"title":"Ext Week 59 n=24"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"194.99","value":"213.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"}],"units":"Participants"}],"title":"Ext Week 67 n=17"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"166.28","value":"157.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"}],"units":"Participants"}],"title":"Ext Week 75 n=18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"134.98","value":"157.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"}],"units":"Participants"}],"title":"Ext Week 83 n=20"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"302.36","value":"180.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"18"}],"units":"Participants"}],"title":"Ext Week 91 n=18"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"375.67","value":"222.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"}],"units":"Participants"}],"title":"Ext Week 99 n=13"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"122.01","value":"118.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"12"}],"units":"Participants"}],"title":"Ext Week 107 n=12"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"80.09","value":"126.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"}],"units":"Participants"}],"title":"Ext Week 115 n=13"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"157.77","value":"147.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"}],"units":"Participants"}],"title":"Ext Week 123 n=13"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"49.92","value":"76.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"}],"units":"Participants"}],"title":"Ext Week 131 n=11"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"73.18","value":"92.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"}],"units":"Participants"}],"title":"Ext Week 139 n=9"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"55.31","value":"90.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"}],"units":"Participants"}],"title":"Ext Week 147 n=9"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"39.05","value":"76.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"}],"units":"Participants"}],"title":"Ext Week 155 n=4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"142.42","value":"141.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"title":"Ext Week 163 n=6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"61.87","value":"89.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"}],"units":"Participants"}],"title":"Ext Week 171 n=6"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"43.06","value":"61.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"}],"units":"Participants"}],"title":"Ext Week 179 n=4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"52.44","value":"89.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"}],"units":"Participants"}],"title":"Ext Week 187 n=4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"40.21","value":"46.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"}],"units":"Participants"}],"title":"Ext Week 195 n=3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"259.15","value":"194.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"}],"units":"Participants"}],"title":"Ext Week 203 n=4"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"37.68","value":"107.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"}],"units":"Participants"}],"title":"Ext Week 211 n=3"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"46.74","value":"70.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"}],"units":"Participants"}],"title":"Ext Week 219 n=2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.99","value":"47.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"}],"units":"Participants"}],"title":"Ext Week 227 n=2"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.83","value":"62.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"}],"units":"Participants"}],"title":"Ext Week 235 n=3"},{"categories":[{"measurements":[{"groupId":"OG000","value":"117.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Ext Week 243 n=1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"202.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Ext Week 251 n=1"},{"categories":[{"measurements":[{"groupId":"OG000","value":"249.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"}],"units":"Participants"}],"title":"Ext Week 267 n=1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"68"}],"units":"Participants"}],"description":"Mean value of mUFC at each scheduled visit was determined from two 24-hour urine collections collected on two consecutive days that occurred before the visit when UFC was measured.","dispersionType":"Standard Deviation","groups":[{"description":"Pasireotide montherapy (0.6 mg bid to 0.9 mg bid) was administered until the biochemical control was achieved and if not achieved, a combination was administered: pasireotide (0.9 mg bid) + cabergoline (0.5 QD to 1 mg QD). Patients were able to add cabergoline at anytime during core and extension","id":"OG000","title":"All Patients"}],"paramType":"MEAN","populationDescription":"Full analysis set. The data beyond Week 139 should be interpreted with caution given that small number of subjects were monitored","reportingStatus":"POSTED","timeFrame":"Baseline, weeks 2, 4, every 4 or 5 weeks during core, every 8 weeks during extension","title":"Mean Urinary Free Cortisol (mUFC) at Scheduled Visits","type":"SECONDARY","unitOfMeasure":"nmol/24h"}