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Low/high DBP (mmHg): \\<= 50 mmHg with decrease from baseline of \\>=15 mmHg/\\>=100 mmHg with increase from baseline of \\>=15 mmHg. Low/high Pulse rate: \\<=50 bpm with decrease from baseline of \\>=15 bpm/\\>= 120 bpm with increase from baseline of \\>=15 bpm. Low/high Weight (kilogram): \\>=20% decrease from baseline/\\>= 10% increase from baseline. Low/high body temperature degree C: \\<= 36 degree C/\\>= 37.5 degree C. Newly occurring was defined as participants not meeting criterion at baseline and meeting criterion post-baseline.","groups":[{"description":"Participants received 300 mg of LGX818 orally once daily along with 45 mg of MEK162 twice daily for each 28 day treatment cycle until PD as confirmed by BIRC, withdrawal of consent, intolerable toxicity, study discontinuation, lost to follow-up or death.","id":"OG000","title":"Part 2: LGX818 300 mg QD+MEK162 45 mg BID (Combo 300)"},{"description":"Participants received 300 mg of LGX818 orally once daily for each 28 day treatment cycle until PD as confirmed by BIRC, withdrawal of consent, intolerable toxicity, study discontinuation, lost to follow-up or death.","id":"OG001","title":"Part 2: LGX818 300 mg"},{"description":"Participants of Part 1 and 2 received 300 mg of LGX818 orally once daily for each 28 day treatment cycle until PD as confirmed by BIRC, withdrawal of consent, intolerable toxicity, and study discontinuation, lost to follow-up or death.","id":"OG002","title":"Part 1 + Part 2: LGX818 300 mg"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"Safety analysis set included all participants who received at least one dose of study medication and have at least one valid post-baseline safety evaluation. Here, \"Overall Number of Participants Analyzed\" signifies number of participants evaluable for this outcome measure and \"Number analyzed\" signifies participants evaluable at specified rows.","reportingStatus":"POSTED","timeFrame":"Baseline up to 30 days after last dose of study drug (up to 106.3 M of treatment exposure for Part 2: LGX818+MEK162 45 mg; up to 98.4 M of treatment exposure for Part 2: LGX818 300 mg; up to 111.4 M of treatment exposure for Part 1+Part 2: LGX818 300 mg)","title":"Part 2: Number of Participants With Newly Occurring Notably Abnormal Vital Signs","type":"SECONDARY","unitOfMeasure":"Participants"}