{"anticipatedPostingDate":"2022-06","denomUnitsSelected":"Participants","description":"Among genes identified whose expression is modified by conditioning, degree of change in expression will be evaluated to determine if it is correlated with relapse risk and offers improved prediction of relapse risk over that obtained with standard clinical parameters (cytogenetics, blast count, International Prognostic Scoring System score, minimal residual disease. To account for censoring and the competing risk of non-relapse mortality (NRM), the analysis will be a time-to-event analysis of relapse using Cox regression, with change in expression as a continuous covariate (on a log scale). 8","reportingStatus":"NOT_POSTED","timeFrame":"Baseline and at day 0 within 6 hours of conditioning prior to transplant","title":"Relapse Risk as Measured by Degree of Change in Gene Expression Profiles","type":"SECONDARY"}