{"analyses":[{"ciLowerLimit":"0.68","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.98","estimateComment":"Tremelimumab is the numerator and placebo, the denominator","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER_LEGACY","pValue":"0.0325","pValueComment":"Estimated using the methods of Klein et al. 2007 and Whitehead and Whitehead 1991, stratified by EORTC status and line of therapy.","paramType":"Hazard Ratio (HR)","paramValue":"0.81","statisticalComment":"Stratification factors were EORTC status and Line of therapy","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"2.66","upperLimit":"2.76","value":"2.69"},{"groupId":"OG001","lowerLimit":"2.76","upperLimit":"2.79","value":"2.76"}]}]}],"denomUnitsSelected":"Participants","denoms":[{"counts":[{"groupId":"OG000","value":"382"},{"groupId":"OG001","value":"189"}],"units":"Participants"}],"description":"Progression-free survival will be measured from randomization to the first documentation of disease progression or death due to any cause, whichever occurs first. Progression is defined using the modified Response Evaluation Criteria in Solid Tumours (RECIST) for pleural mesothelioma or RECIST v1.1 for peritoneal mesothelioma and assessed by computed tomography (CT) or magnetic resonance imaging (MRI), as a 20% increase in the sum of the longest diameter of target lesions, or a measurable increase in a non-target lesion, or the appearance of new lesions.","dispersionType":"95% Confidence Interval","groups":[{"description":"Tremelimumab 10mg/kg","id":"OG000","title":"TREMELIMUMAB"},{"description":"Placebo.","id":"OG001","title":"PLACEBO"}],"paramType":"MEDIAN","populationDescription":"ITT population","reportingStatus":"POSTED","timeFrame":"Time from randomization to disease progression or death, whichever occurs first, assessed up to 3 years.","title":"Progression-free Survival by Treatment Arm","type":"SECONDARY","typeUnitsAnalyzed":"Participants","unitOfMeasure":"Months"}