{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"192.1","value":"633"},{"groupId":"OG001","spread":"91.7","value":"754"},{"groupId":"OG002","spread":"73.8","value":"841"},{"groupId":"OG003","spread":"69.3","value":"906"},{"groupId":"OG004","spread":"37.8","value":"881"},{"groupId":"OG005","spread":"54.5","value":"672"},{"groupId":"OG006","spread":"63.7","value":"785"},{"groupId":"OG007","spread":"80.1","value":"578"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"9"},{"groupId":"OG001","value":"9"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"6"},{"groupId":"OG004","value":"5"},{"groupId":"OG005","value":"3"},{"groupId":"OG006","value":"19"},{"groupId":"OG007","value":"6"}],"units":"Participants"}],"description":"PK samples obtained on the following schedule:\n\nPhase 1b Continuous Dosing, Cycles 1 and 2: Day 1: pre-dose, post-dose at 15 and 30 minutes, 1, 2, 4, 6, and 8 hours post-dose plus pre-dose on Day 2 Phase 1b Step-up Dosing, Day 1: pre-dose, post-dose at 15 and 30 minutes, 1, 2, 4, 6, and 7 hours post-dose plus pre-dose on Day 2 Phase 2, Day 1: pre-dose, post-dose at 15 and 30 minutes, 1, 2, 4, 6, and 7 hours post-dose plus pre-dose on Day 2","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants who were administered 180 mg oprozomib tablets.","id":"OG000","title":"180 mg Oprozomib Tablet"},{"description":"Participants who were administered 210 mg oprozomib tablets.","id":"OG001","title":"210 mg Oprozomib Tablet"},{"description":"Participants who were administered 240 mg oprozomib tablets.","id":"OG002","title":"240 mg Oprozomib Tablet"},{"description":"Participants who were administered 270 mg oprozomib tablets.","id":"OG003","title":"270 mg Oprozomib Tablet"},{"description":"Participants who were administered 300 mg oprozomib tablets.","id":"OG004","title":"300 mg Oprozomib Tablet"},{"description":"Participants who were administered 150 mg extended release oprozomib tablets.","id":"OG005","title":"150 mg Oprozomib ER Tablet"},{"description":"Participants who were administered 300 mg extended release oprozomib tablets.","id":"OG006","title":"300 mg Oprozomib ER Tablet"},{"description":"Participants who were administered 330 mg extended release oprozomib tablets.","id":"OG007","title":"330 mg Oprozomib ER Tablet"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Safety population","reportingStatus":"POSTED","timeFrame":"Day 1","title":"Pharmacokinetic (PK) Parameter for Oprozomib, Tablet and ER Formulation: Maximum Serum Concentration (Cmax) on Cycle 1, Day 1","type":"SECONDARY","unitOfMeasure":"ng/mL"}