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Have you had trouble swallowing?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.57"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.92"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT 34. Did food and drink taste different from usual?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.9"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC 29 Post-HSCT 34. 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Did you worry about the results of examinations and tests?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.6"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT 44. Have you had trouble coping with the hospital stay?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.0"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"}],"units":"Participants"}],"title":"QLQ-HDC 29 Post-HSCT 44. Have you had trouble coping with the hospital stay?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.66"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.66"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT 45. Has the isolation in the hospital troubled you?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.0"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"}],"units":"Participants"}],"title":"QLQ-HDC 29 Post-HSCT 45. Has the isolation in the hospital troubled you?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.0"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.83"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT 46. Have you worried that the blood counts may not recover?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.5"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"3.33"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"}],"units":"Participants"}],"title":"QLQ-HDC 29 Post-HSCT 46. Have you worried that the blood counts may not recover?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.33"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.83"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"6"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT 47. How satisfied were you with the preparation for your treatment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.5"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"2"}],"units":"Participants"}],"title":"QLQ-HDC 29 Post-HSCT 47. How satisfied were you with the preparation for your treatment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.77"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.77"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT 48. Have you felt isolated from those close to you (family, friends)?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.7"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC 29 Post-HSCT 48. Have you felt isolated from those close to you (family, friends)?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.92"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.23"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC 29 Pre-HSCT49.Have you been concerned about disruption to your family life due to treatment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.5"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.22"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC29Post HSCT 49.Have you been concerned about disruption to your family life due to treatment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.62"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.69"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre HSCT 50. How distressing do you think your illness/treatment has been to those close?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.6"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 50. How distressing do you think your illness/treatment has been to those close?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.62"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.84"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"14"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 51. Have you felt a need to keep fears/concerns from family or friends?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.8"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 51. Have you felt a need to keep fears/concerns from family or friends?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.83"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.54"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"12"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"Pre-HSCT 52.Has your experience helped u distinguish between important/non-important things in life?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.1"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"3.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"PostHSCT 52.Has your experience helped u distinguish between important/non-important things in life?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.23"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.46"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 53. Were you worried about your health in the future?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.5"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 53. Were you worried about your health in the future?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.0"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.92"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"13"},{"groupId":"OG001","value":"13"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 54. Have you felt physically less attractive due to illness/treatment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.4"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"10"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 54. Have you felt physically less attractive due to illness/treatment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.75"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.25"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"4"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 55. Have you been concerned about your ability to have children?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.33"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 55. Have you been concerned about your ability to have children?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.28"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"1.88"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 56. Did having to take your drugs regularly interfere with your daily life?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"1.9"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.11"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 56. Did having to take your drugs regularly interfere with your daily life?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.66"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.77"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 57. Have you been watching yourself closely for any new symptoms?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"3.3"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"3.66"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 57. Have you been watching yourself closely for any new symptoms?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.33"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.55"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 58. Have you felt less interest in sex?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.50"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.25"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 58. Have you felt less interest in sex?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.16"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.66"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"9"}],"units":"Participants"}],"title":"QLQ-HDC29 Pre-HSCT 59. Have you felt less sexual enjoyment?"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1","upperLimit":"4","value":"2.6"},{"groupId":"OG001","lowerLimit":"1","upperLimit":"4","value":"2.25"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"10"},{"groupId":"OG001","value":"8"}],"units":"Participants"}],"title":"QLQ-HDC29 Post-HSCT 59. Have you felt less sexual enjoyment?"}],"denoms":[{"counts":[{"groupId":"OG000","value":"25"},{"groupId":"OG001","value":"25"}],"units":"Participants"}],"description":"European Organization for Research and Treatment of Cancer Quality of Life Questionnaire High Dose Chemotherapy (EORTC QLQ-HDC29) is a treatment-specific quality of life questionnaire that addresses treatment specific side effects as well as emotional, social, and family issues for patients treated with high dose regimens and HCT. The QLQ-HDC29 module includes 29 items, consisting of 6 multi-item scales and 8 single-items; all items employ a 4-point Likert scale, ranging from 1 (not at all) to 4 (very much) with lower scores representing a better outcome and higher scores a worse outcome with the exception of question 47 and 52 being the a higher score resulting in a better outcome and lower score a worse outcome.","dispersionType":"Full Range","groups":[{"description":"Patients receive decitabine or azacitidine IV or SC per standard of care. Treatment repeats per standard of care, every 28 days for 4 cycles of decitabine or 6 cycles of azacitidine in the absence of disease progression or unacceptable toxicity.\n\nAzacitidine (AZC): Given IV or SC\n\nDecitabine: Given IV or SC\n\nQuality-of-Life Assessment: Ancillary studies","id":"OG000","title":"Arm A (Decitabine or Azacitidine)"},{"description":"Patients receive physician choice of standard of care or other experimental protocol using induction-like chemotherapy regimen. No one specific regimen is required. Several regimens are listed in the protocol for example only.\n\nQuality-of-Life Assessment: Ancillary studies","id":"OG001","title":"Arm B (Induction-like Chemotherapy Regimen)"}],"paramType":"MEAN","populationDescription":"The QLQ-HDC29 is a validated and widely used questionnaire to assess QOL in cancer patients. For Arm A (Azacitidine or Decitabine) only 14 subjects submitted EORTC QLQ-HDC29 at pre-HCST and 10 subjects post-HSCT. For Arm B (induction chemo) 13 subjects submitted QLQ-HDC29 at pre-HSCT and 10 subjects post-HSCT. Scores for each question and timepoints were averaged to obtain mean. However, there are some questions were subjects noted N/A and these answered were subtracted from the number analyzed.","reportingStatus":"POSTED","timeFrame":"EORTC QLQ-HDC29 questionnaire will be collected after completion of therapy (HMA 4-6 month, and up to 6 months for induction-like chemotherapy) pre stem cell infusion (HSCT), and 100 (± 14) days post stem cell infusion (HSCT).","title":"Quality of Life Will be Assessed Using the EORTC QLQ-HDC29 a Supplementary Module Assessing the Quality of Life During and After High-dose Chemotherapy and Stem Cell Transplantation.","type":"SECONDARY","unitOfMeasure":"units on a scale"}