{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"15"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"15"}],"units":"Participants"}],"title":"Participants Achieving Engraftment with Minimum TNC of 2 x 10^5/kg"},{"categories":[{"measurements":[{"groupId":"OG000","value":"18"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"}],"units":"Participants"}],"title":"Participants Achieving Engraftment with Minimum TNC of 1 x 10^5/kg in umbilical cord blood unit"},{"categories":[{"measurements":[{"groupId":"OG000","value":"20"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"25"}],"units":"Participants"}],"title":"Participants Achieving Engraftment with Minimum TNC of 0.5 x 10^5/kg"}],"denoms":[{"counts":[{"groupId":"OG000","value":"60"}],"units":"Participants"}],"description":"We aim to identify the lowest threshold of umbilical cord total nucleated cell (TNC) dose that can be utilized assure durable umbilical cord blood engraftment in the haplo-cord transplants. The threshold will be defined as the lowest dose which assures cord blood engraftment occurs in at least 80% of subjects.","groups":[{"description":"Haplo-cord transplantation:\n\nFor the transplant component of treatment, subject will receive umbilical cord blood. The study involves transplantation of unlicensed units of cord blood. Therefore, these are considered investigational products.\n\nIn addition to the umbilical cord blood unit, recipients will receive stem cells from a family member ( a haplo-identical donor).","id":"OG000","title":"All Patients"}],"paramType":"NUMBER","populationDescription":"A subset of participants were assessed to analyze the lowest threshold of umbilical cord total nucleated cell (TNC) dose. Once the lowest threshold was established, the remaining participants on study were treated based on that threshold.","reportingStatus":"POSTED","timeFrame":"100 days","title":"Number of Subjects Who Achieved Engraftment With De-Escalating Umbilical Cord Total Nucleated Cell (TNC) Dose","type":"PRIMARY","unitOfMeasure":"participants"}