{"analyses":[{"ciLowerLimit":"0.723","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"1.073","estimateComment":"Lapatinib plus Capecitabine is the reference. Stratified by hormone receptor status, number of prior HER2-directed regimens in the metastatic setting, and visceral disease vs. non-visceral.","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY","pValue":"0.2086","paramType":"Hazard Ratio (HR)","paramValue":"0.881","statisticalComment":"Stratified by hormone receptor status, number of prior HER2-directed regimens in the metastatic setting, and visceral disease vs. non-visceral.","statisticalMethod":"Log Rank"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"22.1","upperLimit":"25.9","value":"24.0"},{"groupId":"OG001","lowerLimit":"20.4","upperLimit":"24.0","value":"22.2"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"307"},{"groupId":"OG001","value":"314"}],"units":"Participants"}],"description":"Overall survival (OS) is defined as the time from randomization to death due to any cause, censored at the last date known alive on or prior to the data cutoff employed for the analysis, whichever was earlier. Here, the time to event was reported as the restricted mean survival time. The restricted mean survival time was defined as the area under the curve of the survival function up to 48 months.","dispersionType":"95% Confidence Interval","groups":[{"description":"neratinib 240 mg orally, once daily with food, continuously in 21 day cycles, and capecitabine 1500 mg/m\\^2 daily in 2 evenly divided doses, orally with water within 30 minutes after a meal, taken on days 1 to 14 of each 21 day cycle.","id":"OG000","title":"Neratinib Plus Capecitabine"},{"description":"lapatinib 1250 mg orally, once daily, continuously in 21 day cycles, and capecitabine 2000 mg/m\\^2 daily in 2 evenly divided doses, orally with water within 30 minutes after a meal, taken on days 1 to 14 of each 21 day cycle.","id":"OG001","title":"Lapatinib Plus Capecitabine"}],"paramType":"MEAN","reportingStatus":"POSTED","timeFrame":"From randomization date to death, assessed up to 59 months.The result is based on primary analysis data cut.","title":"Overall Survival","type":"PRIMARY","unitOfMeasure":"months"}