{"groups":[{"description":"Cohort 1: Total Bone Marrow Irradiation (TBMI): 8 Gy delivered by the Tomotherapy HI-ART machine, in 2 fractions per day during 4 consecutive days from d -6 to d -3.\n\nMelphalan 140 mg/m² infused intravenously during 30 minutes on day -2 after IV anti-emetics.\n\nAutologous Peripheral Stem Cell Rescue : re-infused in the central line on day \"0\" after adequate premedication.","id":"FG000","title":"Total Bone Marrow Irradiation (TBMI): 8 Gy"},{"description":"Cohort 1: Total Bone Marrow Irradiation (TBMI): 10 Gy delivered by the Tomotherapy HI-ART machine, in 2 fractions per day during 4 consecutive days from d -6 to d -3.\n\nMelphalan 140 mg/m² infused intravenously during 30 minutes on day -2 after IV anti-emetics.\n\nAutologous Peripheral Stem Cell Rescue : re-infused in the central line on day \"0\" after adequate premedication.","id":"FG001","title":"Total Bone Marrow Irradiation (TBMI): 10 Gy"},{"description":"Cohort 3: Total Bone Marrow Irradiation (TBMI): 12 Gy delivered by the Tomotherapy HI-ART machine, in 2 fractions per day during 4 consecutive days from d -6 to d -3.\n\nMelphalan 140 mg/m² infused intravenously during 30 minutes on day -2 after IV anti-emetics.\n\nAutologous Peripheral Stem Cell Rescue : re-infused in the central line on day \"0\" after adequate premedication.","id":"FG002","title":"Total Bone Marrow Irradiation (TBMI): 12 Gy"},{"description":"Cohort 4: Total Bone Marrow Irradiation (TBMI): 14 Gy delivered by the Tomotherapy HI-ART machine, in 2 fractions per day during 4 consecutive days from d -6 to d -3.\n\nMelphalan 140 mg/m² infused intravenously during 30 minutes on day -2 after IV anti-emetics.\n\nAutologous Peripheral Stem Cell Rescue : re-infused in the central line on day \"0\" after adequate premedication.","id":"FG003","title":"Total Bone Marrow Irradiation (TBMI): 14 Gy"},{"description":"Cohort 5: Total Bone Marrow Irradiation (TBMI): 16 Gy delivered by the Tomotherapy HI-ART machine, in 2 fractions per day during 4 consecutive days from d -6 to d -3.\n\nMelphalan 140 mg/m² infused intravenously during 30 minutes on day -2 after IV anti-emetics.\n\nAutologous Peripheral Stem Cell Rescue : re-infused in the central line on day \"0\" after adequate premedication.","id":"FG004","title":"Total Bone Marrow Irradiation (TBMI): 16 Gy"}],"periods":[{"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"3"},{"groupId":"FG002","numSubjects":"6"},{"groupId":"FG003","numSubjects":"1"},{"groupId":"FG004","numSubjects":"0"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"3"},{"groupId":"FG001","numSubjects":"3"},{"groupId":"FG002","numSubjects":"6"},{"groupId":"FG003","numSubjects":"1"},{"groupId":"FG004","numSubjects":"0"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"0"},{"groupId":"FG002","numSubjects":"0"},{"groupId":"FG003","numSubjects":"0"},{"groupId":"FG004","numSubjects":"0"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}],"recruitmentDetails":"Study start date: April 9, 2013 Study completion date: October 6, 2020"}