{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.212","value":"2220"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"25"}],"units":"Participants"}],"description":"Vd is defined as the theoretical central volume in which the total amount of drug would need to be uniformly distributed to produce the desired plasma concentration of a drug. Vd was calculated in millilitres (mL).","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants received rituximab as an intravenous (IV) infusion of 375 milligrams per meter squared (mg/m\\^2) once a week on Days 1, 8, 15 and 22 during the Remission Induction Phase (Day 1 (baseline) to Month 6) and were followed for a minimum of 18 months (maximum 4.5yrs) during the Follow-up Phase until the Common-closeout (CCO))","id":"OG000","title":"Rituximab (Experimental)"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"The PK analysis population included all participants in the safety population who provided at least one evaluable PK sample.","reportingStatus":"POSTED","timeFrame":"From Day 1 to Day 180","title":"Pharmacokinetics: Volume of Distribution (Vd) of Rituximab","type":"PRIMARY","unitOfMeasure":"mL"}