{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"},{"groupId":"OG004","spread":"0.0","value":"0.0"},{"groupId":"OG005","spread":"0.0","value":"0.0"},{"groupId":"OG006","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"Cycle1 Day1 (C1D1) 0 hr pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"97.9","value":"104"},{"groupId":"OG001","spread":"94.7","value":"99.0"},{"groupId":"OG002","spread":"90.6","value":"112"},{"groupId":"OG003","spread":"0.6","value":"126"},{"groupId":"OG004","spread":"138.1","value":"52.4"},{"groupId":"OG005","spread":"58.3","value":"197"},{"groupId":"OG006","spread":"82.3","value":"72.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"C1D1 2 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"39.6","value":"216"},{"groupId":"OG001","spread":"69.0","value":"233"},{"groupId":"OG002","spread":"93.5","value":"250"},{"groupId":"OG003","spread":"54.7","value":"350"},{"groupId":"OG004","spread":"92.8","value":"166"},{"groupId":"OG005","spread":"28.1","value":"311"},{"groupId":"OG006","spread":"34.1","value":"153"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"C1D1 4 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"33.8","value":"227"},{"groupId":"OG001","spread":"78.1","value":"245"},{"groupId":"OG002","spread":"97.2","value":"245"},{"groupId":"OG003","spread":"74.2","value":"423"},{"groupId":"OG004","spread":"35.3","value":"275"},{"groupId":"OG005","spread":"36.7","value":"318"},{"groupId":"OG006","spread":"68.9","value":"168"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"title":"C1D1 6 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"66.3","value":"130"},{"groupId":"OG001","spread":"89.9","value":"141"},{"groupId":"OG002","spread":"117.2","value":"86.4"},{"groupId":"OG003","spread":"73.6","value":"268"},{"groupId":"OG004","spread":"63.7","value":"98.5"},{"groupId":"OG005","spread":"107.7","value":"126"},{"groupId":"OG006","spread":"111.3","value":"161"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"title":"C1D1 24 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"66.3","value":"130"},{"groupId":"OG001","spread":"89.9","value":"141"},{"groupId":"OG002","spread":"117.2","value":"86.4"},{"groupId":"OG003","spread":"73.6","value":"268"},{"groupId":"OG004","spread":"63.7","value":"98.5"},{"groupId":"OG005","spread":"107.7","value":"126"},{"groupId":"OG006","spread":"111.3","value":"161"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"11"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"4"}],"units":"Participants"}],"title":"C1D2 0 hr pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"99.6","value":"193"},{"groupId":"OG001","spread":"64.6","value":"618"},{"groupId":"OG002","spread":"49.9","value":"537"},{"groupId":"OG003","spread":"5.1","value":"942"},{"groupId":"OG004","spread":"118.4","value":"262"},{"groupId":"OG005","spread":"119.2","value":"379"},{"groupId":"OG006","spread":"76.3","value":"461"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"C1D15 0 hr pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"299.5","value":"169"},{"groupId":"OG001","spread":"53.5","value":"661"},{"groupId":"OG002","spread":"45.4","value":"672"},{"groupId":"OG003","spread":"152.7","value":"695"},{"groupId":"OG004","spread":"103.7","value":"218"},{"groupId":"OG005","spread":"73.8","value":"429"},{"groupId":"OG006","spread":"12.4","value":"655"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"3"}],"units":"Participants"}],"title":"C2D1 0 hr pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"85.4","value":"287"},{"groupId":"OG001","spread":"61.6","value":"687"},{"groupId":"OG002","spread":"45.9","value":"801"},{"groupId":"OG003","spread":"99.6","value":"662"},{"groupId":"OG004","spread":"112.4","value":"196"},{"groupId":"OG005","spread":"96.6","value":"475"},{"groupId":"OG006","spread":"21.1","value":"718"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"3"}],"units":"Participants"}],"title":"C2D1 2 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"47.6","value":"386"},{"groupId":"OG001","spread":"51.9","value":"810"},{"groupId":"OG002","spread":"30.4","value":"1000"},{"groupId":"OG003","spread":"30.1","value":"1230"},{"groupId":"OG004","spread":"133.9","value":"262"},{"groupId":"OG005","spread":"86.6","value":"631"},{"groupId":"OG006","spread":"13.2","value":"744"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"3"}],"units":"Participants"}],"title":"C2D1 4 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"38.4","value":"426"},{"groupId":"OG001","spread":"47.8","value":"852"},{"groupId":"OG002","spread":"37.6","value":"898"},{"groupId":"OG003","spread":"16.4","value":"1260"},{"groupId":"OG004","spread":"130.3","value":"300"},{"groupId":"OG005","spread":"105.5","value":"648"},{"groupId":"OG006","spread":"7.7","value":"786"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"2"}],"units":"Participants"}],"title":"C2D1 6 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"46.9","value":"247"},{"groupId":"OG001","spread":"53.7","value":"651"},{"groupId":"OG002","spread":"40.8","value":"714"},{"groupId":"OG003","spread":"72.2","value":"847"},{"groupId":"OG004","spread":"106.5","value":"194"},{"groupId":"OG005","spread":"147.3","value":"411"},{"groupId":"OG006","spread":"43.9","value":"448"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"C2D1 24 hrs post-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"46.9","value":"247"},{"groupId":"OG001","spread":"53.7","value":"651"},{"groupId":"OG002","spread":"40.8","value":"714"},{"groupId":"OG003","spread":"72.2","value":"847"},{"groupId":"OG004","spread":"106.5","value":"194"},{"groupId":"OG005","spread":"147.3","value":"411"},{"groupId":"OG006","spread":"43.9","value":"448"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"3"},{"groupId":"OG005","value":"4"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"C2D2 0 hr pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"94.4","value":"399"},{"groupId":"OG001","spread":"34.3","value":"810"},{"groupId":"OG002","spread":"117.7","value":"415"},{"groupId":"OG003","spread":"0.0","value":"1320"},{"groupId":"OG004","spread":"218.3","value":"167"},{"groupId":"OG005","spread":"0.0","value":"328"},{"groupId":"OG006","spread":"128.5","value":"433"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"8"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"2"},{"groupId":"OG005","value":"1"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"title":"C3D1 0 hr pre-dose"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"35.1","value":"503"},{"groupId":"OG001","spread":"36.2","value":"960"},{"groupId":"OG002","spread":"874.8","value":"321"},{"groupId":"OG003","spread":"0.0","value":"857"},{"groupId":"OG004","spread":"0.0","value":"403"},{"groupId":"OG005","spread":"0.0","value":"1320"},{"groupId":"OG006","spread":"27.0","value":"658"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"8"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"1"},{"groupId":"OG006","value":"3"}],"units":"Participants"}],"title":"C4D1 0 hr pre-dose"}],"denoms":[{"counts":[{"groupId":"OG000","value":"5"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"5"},{"groupId":"OG006","value":"5"}],"units":"Participants"}],"description":"Characterize single and multiple-dose PK of LDK378 in pediatric patients. Only PK plasma concentrations with non-missing sampling date and time, and for which the last dose date and time prior to the PK sample draw are non-missing, were included in the PK analysis.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants in the fasted group who took 300 mg of ceritinib","id":"OG000","title":"Fasted: Ceritinib 300 mg/m2"},{"description":"Participants in the fasted group who took 450 mg of ceritinib","id":"OG001","title":"Fasted: Ceritinib 450 mg/m2"},{"description":"Participants in the fasted group who took 510 mg of ceritinib","id":"OG002","title":"Fasted: Ceritinib 510 mg/m2"},{"description":"Participants in the fasted group who took 560 mg of ceritinib","id":"OG003","title":"Fasted: Ceritinib 560 mg/m2"},{"description":"Participants in the fed group who took 320 mg of ceritinib","id":"OG004","title":"Fed: Ceritinib 320 mg/m2"},{"description":"Participants in the fed group who took 400 mg of ceritinib","id":"OG005","title":"Fed: Ceritinib 400 mg/m2"},{"description":"Participants in the fed group who took 500 mg of ceritinib","id":"OG006","title":"Fed: Ceritinib 500 mg/m2"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"The PK analysis set (PAS) consisted of all patients who received at least one dose of ceritinib and had at least one evaluable PK sample.","reportingStatus":"POSTED","timeFrame":"0hr pre-dose, 2hrs post-dose, 4hrs post-dose, 6hrs post-dose & 24hrs post-dose in Cycle1 Day1 & Cycle 2 day 1; 0hr pre-dose in Cycle 1 Day 15, Cycle 2 Day1, Cycle 2 Day 2, Cycle 3 day 1 & Cycle 4 Day 1","title":"Plasma Concentration Time Profiles by Treatment Group in Escalation Phase","type":"SECONDARY","unitOfMeasure":"ng/mL"}