{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"5.8","upperLimit":"22.2","value":"15.0"},{"comment":"N/A: Median not reached for subjects with ALCL, IMT \\& Other tumor types as most of the subjects did not have a DOR event (progression or death).","groupId":"OG001","lowerLimit":"3.5","upperLimit":"NA","value":"NA"},{"comment":"N/A: Median not reached for subjects with ALCL, IMT \\& Other tumor types as most of the subjects did not have a DOR event (progression or death).","groupId":"OG002","lowerLimit":"2.8","upperLimit":"NA","value":"NA"},{"comment":"N/A: Median not reached for subjects with ALCL, IMT \\& Other tumor types as most of the subjects did not have a DOR event (progression or death).","groupId":"OG003","lowerLimit":"NA","upperLimit":"NA","value":"NA"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"7"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"description":"DOR is defined as the time from first documented response (PR or CR) to the date of first documented disease progression (PD) or death due to any cause. DOR was assessed per Investigator as per RECIST 1.1 in participants with neuroblastoma and other solid tumors, and by International Working Group (IWG) criteria in patients with lymphoma. Per RECIST 1.1 (for neuroblastoma \\& other solid tumors): CR: disappearance of all non-nodal target lesions. In addition, any pathological lymph nodes assigned as target lesions must have a reduction in short axis to \\< 10 mm. PR: at least a 30% decrease in the sum of diameter of all target lesion, taking as reference the baseline sum diameters. Per IWG criteria (for patients with lymphoma): CR: normalization of all index nodal lesions or complete disappearance of all index extranodal lesions. PR: at least 50% decrease from baseline in the sum of diameters of all index lesions.","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants with ALK-activated neuroblastoma enrolled in the expansion part of the study and were given ceritinib once daily, continuously","id":"OG000","title":"ALK-activated Neuroblastoma"},{"description":"Participants with ALK-activated IMT enrolled in the expansion part of the study who were given ceritinib once daily, continuously","id":"OG001","title":"ALK-activated Inflammatory Myofibroblastic Tumors (IMT)"},{"description":"Participants with ALK-activated ALCL enrolled in the expansion part of the study who were given ceritinib once daily, continuously","id":"OG002","title":"ALK-activated Anaplastic Large Cell Lymphoma (ALCL)"},{"description":"Participants with other ALK-activated tumors enrolled in the expansion part of the study who were given ceritinib once daily, continuously","id":"OG003","title":"ALK-activated Other"}],"paramType":"MEDIAN","populationDescription":"Full Analysis Set/MTD/RDE patients with confirmed CR or PR): Efficacy results are presented only for patients with confirmed CR or PR who received at least 1 dose of ceritinib in either of the 2 MTD/RDE groups \\& were based on combining data from across the dose-escalation \\& dose-expansion phases, \\& summarized according to primary tumor diagnosis.","reportingStatus":"POSTED","timeFrame":"30 months","title":"Duration of Response (DoR) Per Investigator Assessment","type":"SECONDARY","unitOfMeasure":"months"}