{"analyses":[{"ciLowerLimit":"-0.004","ciNumSides":"TWO_SIDED","ciPctValue":"95","ciUpperLimit":"0.051","groupIds":["OG000","OG001"],"nonInferiorityType":"SUPERIORITY_OR_OTHER_LEGACY","pValue":"0.0925","paramType":"Mean Difference (Final Values)","paramValue":"0.023","statisticalComment":"Analysis based on repeated measures mixed-effects model with an intercept term, treatment, time, treatment-by-time, and baseline as covariate.","statisticalMethod":"Mixed Models Analysis"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.00","upperLimit":"0.03","value":"0.014"},{"groupId":"OG001","lowerLimit":"-0.03","upperLimit":"0.01","value":"-0.010"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"437"},{"groupId":"OG001","value":"218"}],"units":"Participants"}],"description":"The EuroQol EQ-5D is a 6-item instrument designed to assess health status in terms of a single index value or utility score. It contains 5 descriptors of current health state (mobility, self-care, usual activities, pain or discomfort, and anxiety or depression) with each dimension having 3 levels of function (1=no problem, 2=some problem, and 3=extreme problem). The scores on the 5 descriptors are summarized to create a single summary score. An overall utility score is calculated based on these domains, with a range score from 0 (worse health scenario) to a maximum of 1.0 (best health scenario).","dispersionType":"95% Confidence Interval","groups":[{"description":"Participants received letrozole 2.5 milligram (mg) orally QD (once daily) combined with palbociclib 125 mg QD for 21 days of every-28-day cycle, followed by 7 days off treatment.","id":"OG000","title":"Palbociclib Plus Letrozole"},{"description":"Participants received letrozole 2.5 mg orally QD combined with placebo QD for 21 days of every-28-day cycle, followed by 7 days off treatment.","id":"OG001","title":"Placebo Plus Letrozole"}],"paramType":"MEAN","populationDescription":"Patient Reported Outcome (PRO) Analysis Set is a subset of ITT participants, who had both baseline and at least one follow-up PRO assessment.","reportingStatus":"POSTED","timeFrame":"From Baseline up to 2.5 years","title":"Change From Baseline Between Treatment Comparison in Euro Quality of Life (EQ-5D) Index","type":"SECONDARY","unitOfMeasure":"Units on a scale"}