{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.67","upperLimit":"3.26","value":"0.80"},{"groupId":"OG001","lowerLimit":"-0.19","upperLimit":"6.10","value":"2.95"}]}],"title":"QTcS at 0 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.79","upperLimit":"5.85","value":"3.32"},{"groupId":"OG001","lowerLimit":"-1.48","upperLimit":"4.78","value":"1.65"}]}],"title":"QTcS at 2 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.23","upperLimit":"5.30","value":"2.76"},{"groupId":"OG001","lowerLimit":"-1.39","upperLimit":"4.87","value":"1.74"}]}],"title":"QTcS at 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.96","upperLimit":"7.02","value":"4.49"},{"groupId":"OG001","lowerLimit":"-2.41","upperLimit":"3.85","value":"0.72"}]}],"title":"QTcS at 6 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.60","upperLimit":"3.48","value":"0.94"},{"groupId":"OG001","lowerLimit":"0.01","upperLimit":"6.27","value":"3.14"}]}],"title":"QTcS at 8 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.39","upperLimit":"3.58","value":"1.10"},{"groupId":"OG001","lowerLimit":"-0.11","upperLimit":"6.23","value":"3.06"}]}],"title":"QTcF at 0 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.12","upperLimit":"6.23","value":"3.68"},{"groupId":"OG001","lowerLimit":"-1.43","upperLimit":"4.88","value":"1.73"}]}],"title":"QTcF at 2 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.31","upperLimit":"5.41","value":"2.86"},{"groupId":"OG001","lowerLimit":"-1.62","upperLimit":"4.70","value":"1.54"}]}],"title":"QTcF at 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"2.01","upperLimit":"7.12","value":"4.57"},{"groupId":"OG001","lowerLimit":"-2.44","upperLimit":"3.87","value":"0.71"}]}],"title":"QTcF at 6 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.36","upperLimit":"3.77","value":"1.21"},{"groupId":"OG001","lowerLimit":"-0.31","upperLimit":"6.00","value":"2.84"}]}],"title":"QTcF at 8 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-2.83","upperLimit":"2.61","value":"-0.11"},{"groupId":"OG001","lowerLimit":"-0.69","upperLimit":"6.25","value":"2.78"}]}],"title":"QTcB at 0 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-1.34","upperLimit":"4.25","value":"1.46"},{"groupId":"OG001","lowerLimit":"-2.63","upperLimit":"4.28","value":"0.83"}]}],"title":"QTcB at 2 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-0.22","upperLimit":"5.38","value":"2.58"},{"groupId":"OG001","lowerLimit":"-0.98","upperLimit":"5.92","value":"2.47"}]}],"title":"QTcB at 4 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.24","upperLimit":"6.83","value":"4.03"},{"groupId":"OG001","lowerLimit":"-2.92","upperLimit":"3.99","value":"0.53"}]}],"title":"QTcB at 6 hour"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"-2.98","upperLimit":"2.64","value":"-0.17"},{"groupId":"OG001","lowerLimit":"0.69","upperLimit":"7.59","value":"4.14"}]}],"title":"QTcB at 8 hour"}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"47"}],"units":"Participants"}],"description":"Triplicate 12-lead ECG measurements (each recording separated by approximately 2 minutes) were performed and sent to a central laboratory for blinded manual adjudication. The average was calculated. The time corresponding to beginning of depolarization to repolarization of the ventricles (QT interval) was adjusted for RR interval using QT and RR from each ECG by Fridericia's formula (QTcF = QT divided by cube root of RR), by Bazette's formula (QTcB = QT divided by square root of RR) and corrected QT interval according to study-specific criteria (QTcS). Time-matched change from baseline values were reported for QTc analysis population.","dispersionType":"90% Confidence Interval","groups":[{"description":"Participants received letrozole 2.5 milligram (mg) orally QD (once daily) combined with palbociclib 125 mg QD for 21 days of every-28-day cycle, followed by 7 days off treatment.","id":"OG000","title":"Palbociclib Plus Letrozole"},{"description":"Participants received letrozole 2.5 mg orally QD combined with placebo QD for 21 days of every-28-day cycle, followed by 7 days off treatment.","id":"OG001","title":"Placebo Plus Letrozole"}],"paramType":"LEAST_SQUARES_MEAN","populationDescription":"QTc analysis set is a subset of as treated (AT) population who were in Group 1; their QTc was used to study the effect of palbociclib on QT interval via serial triplicate ECGs with PK draws; and who had \\>= 1 pair of time-matched Day 0 and palbociclib postdose (Cycle1 Day14) measurements.","reportingStatus":"POSTED","timeFrame":"Time-matched triplicate ECGs were collected at 0 (predose), 2, 4, 6 and 8 hours on Day 0 and on Cycle1 Day14","title":"Corrected QT Interval (QTc) Time-Matched Change From Baseline on Cycle 1 Day 14","type":"SECONDARY","unitOfMeasure":"msec"}