{"groups":[{"description":"Subjects will receive the current standard of care treatment. Lenalidomide and dexamethasone for four 28-day cycles followed by stem cell collection and autologous peripheral blood stem cell transplant. After 90 days, start the maintenance phase (lenalidomide days 1-21 every 28 days for two years or until your disease progresses).\n\nAutologous peripheral blood stem cell transplant: Subjects deemed suitable by the principal investigator will undergo autologous peripheral blood stem cell transplantation on day 0.\n\nLenalidomide: Administered orally at a dose 25 mg daily on days 1-21 of each 28-day cycle.\n\nDexamethasone: Administered orally at a dose of 40 mg daily on days 1, 8, 15, 22 of each cycle.\n\nStem cell collection: Peripheral stem cell collection will be performed at marrow recovery, usually when white blood cell (WBC) is \\>2500 x 109 cells/liter; platelet count is \\>20 x 103/mm3.\n\nMelphalan: Subjects undergoing autologous peripheral blood stem cell transplant will receive","id":"FG000","title":"Arm A: Low-dose Dexamethasone + Stem Cell Transplantation"},{"description":"Subjects will receive the new treatment that will be compared with the standard of care. Lenalidomide and dexamethasone for eight 28-day cycles. After four cycles your stem cells will be collected (stem cell collection). After an additional four cycles of lenalidomide (a total of 8 cycles), start the maintenance phase (lenalidomide days 1-21 every 28 days for two years or until your disease progresses).\n\nLenalidomide: Administered orally at a dose 25 mg daily on days 1-21 of each 28-day cycle.\n\nDexamethasone: Administered orally at a dose of 40 mg daily on days 1, 8, 15, 22 of each cycle.\n\nStem cell collection: Peripheral stem cell collection will be performed at marrow recovery, usually when white blood cell (WBC) is \\>2500 x 109 cells/liter; platelet count is \\>20 x 103/mm3.\n\nCyclophosphamide: Subjects may receive up to the maximum recommended high-dose of cyclophosphamide at 4 gm/m2 intravenously.\n\nMesna: Mesna will be provided with the cyclophosphamide.","id":"FG001","title":"Arm B: Low-dose Dexamethasone"}],"periods":[{"dropWithdraws":[{"reasons":[{"groupId":"FG000","numSubjects":"1"},{"groupId":"FG001","numSubjects":"0"}],"type":"Death"},{"reasons":[{"groupId":"FG000","numSubjects":"0"},{"groupId":"FG001","numSubjects":"1"}],"type":"Never started treatment"},{"reasons":[{"groupId":"FG000","numSubjects":"1"},{"groupId":"FG001","numSubjects":"0"}],"type":"Non-compliant"}],"milestones":[{"achievements":[{"groupId":"FG000","numSubjects":"31"},{"groupId":"FG001","numSubjects":"29"}],"type":"STARTED"},{"achievements":[{"groupId":"FG000","numSubjects":"29"},{"groupId":"FG001","numSubjects":"28"}],"type":"COMPLETED"},{"achievements":[{"groupId":"FG000","numSubjects":"2"},{"groupId":"FG001","numSubjects":"1"}],"type":"NOT COMPLETED"}],"title":"Overall Study"}]}