{"analyses":[{"groupDescription":"Collagen.5.g.ml, 24 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.181","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Collagen.2.g.ml","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":".164","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"ADP.10.M, 24 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":".132","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"ADP.5.M","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":".066","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"ADP.3.M, 24 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.268","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Arach.Acid.0.5.mg.ml","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.106","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Ristocetin.1.5.mg.ml","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.625","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Ristocetin.0.5.mg.ml","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.381","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Collagen.5.g.ml, 48 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.549","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Collagen.2.g.ml, 48 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":".838","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"ADP.10.M","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.245","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"ADP.5.M","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.417","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"ADP.3.M, 48 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.770","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Arach.Acid.0.5.mg.ml, 48 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.614","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Ristochetin.1.5.mg.ml","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.969","statisticalMethod":"t-test, 2 sided"},{"groupDescription":"Ristocetin.0.5.mg.ml, 48 hrs","groupIds":["OG000"],"nonInferiorityType":"SUPERIORITY","pValue":"0.238","statisticalMethod":"t-test, 2 sided"}],"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.244","value":"-4.143"}]}],"title":"Collagen 5.g.ml, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.390","value":"-4.429"}]}],"title":"Collagen 2.g.ml, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.949","value":"-4.571"}]}],"title":"ADP.10.M, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.591","value":"-6.429"}]}],"title":"ADP.5.M, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.400","value":"-7.571"}]}],"title":"ADP.3.M, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.507","value":"-11.143"}]}],"title":"Arach.Acid.0.5.mg.ml, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.345","value":"-1.429"}]}],"title":"Ristocetin1.5.mg.ml, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.803","value":"-2.429"}]}],"title":"Ristocetin.0.5.mg.ml, 24 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.130","value":"-2.429"}]}],"title":"Collagen.5.g.mL, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.605","value":"-0.857"}]}],"title":"Collagen.2.g.mL, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.044","value":"-3.429"}]}],"title":"ADP.10.M, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.845","value":"-3.571"}]}],"title":"ADP.5.M, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.587","value":"1.571"}]}],"title":"ADP.3.M, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.368","value":"-2.286"}]}],"title":"Arach.Acid.0.5.mg.mL, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.353","value":".0143"}]}],"title":"Ristocetin.1.5.mg.mL, 48 hrs"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.041","value":"-2.000"}]}],"title":"Ristocetin.0.5.mg.mL, 48 hrs"}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"}],"units":"Participants"}],"description":"Effect of VELCADE at 1.0-1.3 mg/m2 dose on platelet aggregation at 24 and 48 hour post-infusion in patients with multiple myeloma. The following components of platelet aggregation were evaluated at varying levels: Collagen, Adenine di-Phosphate (ADP), Arachidonic acid, and Ristocetin.","dispersionType":"Standard Deviation","groups":[{"description":"All participants enrolled\n\nVelcade: Single dose of Velcade (1.0-1.3 mg/m2 dose)","id":"OG000","title":"All Participants"}],"paramType":"MEAN","populationDescription":"One patient withdrew before receiving the 24 hour dose, leaving 7 patients evaluable for response.","reportingStatus":"POSTED","timeFrame":"48 hours","title":"Efficacy of Velcade","type":"PRIMARY","unitOfMeasure":"percentage"}