{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"133.3","value":"17.0"},{"groupId":"OG001","spread":"54.2","value":"14.2"},{"groupId":"OG002","spread":"78.4","value":"7.87"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"16"},{"groupId":"OG002","value":"4"}],"units":"Participants"}],"dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants in phase 1 and phase 2 received carfilzomib 20 mg/m² administered by intravenous (IV) infusion on day 1 cycle 1.","id":"OG000","title":"Carfilzomib 20 mg/m²"},{"description":"Participants in phase 1 and phase 2 received carfilzomib 70 mg/m² administered by intravenous (IV) infusion from day 8 cycle 1 onwards.","id":"OG001","title":"Carfilzomib 70 mg/m²"},{"description":"Participants in phase 1 received carfilzomib 88 mg/m² administered by intravenous (IV) infusion from day 8 cycle 1 onwards.","id":"OG002","title":"Carfilzomib 88 mg/m²"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Pharmacokinetic (PK) analyses were conducted for participants assigned to cohorts 3 and 4 in phase 1 (70 and 88 mg/m² carfilzomib) and a subset of participants in phase 2; only participants for whom PK parameters could be calculated were included in the analyses.","reportingStatus":"POSTED","timeFrame":"Day 1 cycle 1 (20 mg/m² carfilzomib), cycle 1 day 15 (phase 1 70 and 88 mg/m² carfilzomib), and cycle 2 day 15 (phase 2 70 mg/m² carfilzomib) from predose to 4 hours after the end of the infusion.","title":"Volume of Distribution Observed at Steady State (Vss) for Carfilzomib","type":"SECONDARY","unitOfMeasure":"liters"}