{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.2","value":"3.6"},{"groupId":"OG001","spread":"14.9","value":"3.9"},{"groupId":"OG002","spread":"10.3","value":"3.5"},{"groupId":"OG003","spread":"11.3","value":"3.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"86"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Appetite Loss: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.4","value":"2.8"},{"groupId":"OG001","spread":"7.1","value":"1.5"},{"groupId":"OG002","spread":"16.0","value":"10.4"},{"groupId":"OG003","spread":"11.1","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.5","value":"16.7"},{"groupId":"OG001","spread":"12.0","value":"1.4"},{"groupId":"OG002","spread":"22.8","value":"12.2"},{"groupId":"OG003","spread":"17.5","value":"1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"79"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.3","value":"7.6"},{"groupId":"OG001","spread":"10.0","value":"3.2"},{"groupId":"OG002","spread":"20.6","value":"11.1"},{"groupId":"OG003","spread":"20.0","value":"3.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.0","value":"9.5"},{"groupId":"OG001","spread":"10.1","value":"1.2"},{"groupId":"OG002","spread":"23.7","value":"12.2"},{"groupId":"OG003","spread":"15.4","value":"1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"126"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.2","value":"9.5"},{"groupId":"OG001","spread":"12.2","value":"1.0"},{"groupId":"OG002","spread":"16.3","value":"6.8"},{"groupId":"OG003","spread":"14.9","value":"0.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"79"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.7","value":"10.4"},{"groupId":"OG001","spread":"10.1","value":"1.6"},{"groupId":"OG002","spread":"18.0","value":"8.3"},{"groupId":"OG003","spread":"14.8","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"77"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.9","value":"9.5"},{"groupId":"OG001","spread":"12.1","value":"1.3"},{"groupId":"OG002","spread":"20.3","value":"10.3"},{"groupId":"OG003","spread":"15.2","value":"2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.5","value":"13.3"},{"groupId":"OG001","spread":"12.7","value":"1.4"},{"groupId":"OG002","spread":"15.0","value":"7.4"},{"groupId":"OG003","spread":"12.6","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.1","value":"9.7"},{"groupId":"OG001","spread":"12.4","value":"2.4"},{"groupId":"OG002","spread":"21.6","value":"13.0"},{"groupId":"OG003","spread":"17.9","value":"1.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.8","value":"10.7"},{"groupId":"OG001","spread":"14.0","value":"1.5"},{"groupId":"OG002","spread":"16.1","value":"7.4"},{"groupId":"OG003","spread":"18.7","value":"4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.7","value":"10.2"},{"groupId":"OG001","spread":"13.7","value":"1.9"},{"groupId":"OG002","spread":"18.7","value":"10.8"},{"groupId":"OG003","spread":"12.2","value":"-0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"105"},{"groupId":"OG001","value":"105"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.2","value":"9.7"},{"groupId":"OG001","spread":"13.5","value":"2.3"},{"groupId":"OG002","spread":"17.7","value":"7.9"},{"groupId":"OG003","spread":"15.7","value":"3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"7.3"},{"groupId":"OG001","spread":"15.5","value":"1.7"},{"groupId":"OG002","spread":"15.7","value":"4.8"},{"groupId":"OG003","spread":"12.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"5.4"},{"groupId":"OG001","spread":"14.2","value":"1.8"},{"groupId":"OG002","spread":"13.3","value":"4.7"},{"groupId":"OG003","spread":"12.8","value":"0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.9","value":"8.5"},{"groupId":"OG001","spread":"14.0","value":"1.5"},{"groupId":"OG002","spread":"15.3","value":"7.3"},{"groupId":"OG003","spread":"11.9","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.2","value":"5.7"},{"groupId":"OG001","spread":"13.6","value":"1.9"},{"groupId":"OG002","spread":"14.6","value":"6.2"},{"groupId":"OG003","spread":"11.2","value":"0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Appetite Loss: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.3","value":"2.7"},{"groupId":"OG001","spread":"20.1","value":"0.8"},{"groupId":"OG002","spread":"18.7","value":"5.1"},{"groupId":"OG003","spread":"18.8","value":"2.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"66"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Appetite Loss: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.2","value":"0.0"},{"groupId":"OG001","spread":"16.5","value":"1.8"},{"groupId":"OG002","spread":"6.3","value":"-1.2"},{"groupId":"OG003","spread":"10.8","value":"1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.6","value":"0.7"},{"groupId":"OG001","spread":"15.3","value":"-1.4"},{"groupId":"OG002","spread":"17.4","value":"3.5"},{"groupId":"OG003","spread":"12.7","value":"1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.5","value":"-0.4"},{"groupId":"OG001","spread":"7.0","value":"-0.5"},{"groupId":"OG002","spread":"9.0","value":"-0.8"},{"groupId":"OG003","spread":"14.3","value":"2.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.6","value":"0.4"},{"groupId":"OG001","spread":"12.1","value":"0.0"},{"groupId":"OG002","spread":"6.5","value":"-1.3"},{"groupId":"OG003","spread":"9.2","value":"2.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"26"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.1","value":"-1.9"},{"groupId":"OG001","spread":"14.5","value":"0.9"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"17.1","value":"5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.1","value":"-0.7"},{"groupId":"OG001","spread":"14.3","value":"2.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"11.1","value":"3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.8","value":"2.1"},{"groupId":"OG001","spread":"12.4","value":"2.3"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"9.6","value":"2.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.3","value":"-1.2"},{"groupId":"OG001","spread":"6.7","value":"-1.3"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"11.1","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.5","value":"-1.5"},{"groupId":"OG001","spread":"14.3","value":"2.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"groupId":"OG001","spread":"17.2","value":"2.8"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.6","value":"-4.8"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Appetite Loss: Change at PT/Discontinuation"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.1","value":"93.0"},{"groupId":"OG001","spread":"16.2","value":"92.0"},{"groupId":"OG002","spread":"17.2","value":"91.4"},{"groupId":"OG003","spread":"11.6","value":"94.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Cognitive Functioning: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.3","value":"-2.1"},{"groupId":"OG001","spread":"14.5","value":"1.5"},{"groupId":"OG002","spread":"10.5","value":"0.0"},{"groupId":"OG003","spread":"6.2","value":"2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.1","value":"-4.3"},{"groupId":"OG001","spread":"12.6","value":"0.8"},{"groupId":"OG002","spread":"13.4","value":"-3.8"},{"groupId":"OG003","spread":"11.5","value":"-0.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.4","value":"-0.8"},{"groupId":"OG001","spread":"11.7","value":"1.6"},{"groupId":"OG002","spread":"9.3","value":"-3.3"},{"groupId":"OG003","spread":"14.1","value":"-4.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.2","value":"-2.4"},{"groupId":"OG001","spread":"14.3","value":"-2.5"},{"groupId":"OG002","spread":"12.2","value":"-2.2"},{"groupId":"OG003","spread":"13.9","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.1","value":"-3.8"},{"groupId":"OG001","spread":"14.6","value":"-1.1"},{"groupId":"OG002","spread":"11.9","value":"-3.1"},{"groupId":"OG003","spread":"15.2","value":"-0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"80"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.4","value":"-3.6"},{"groupId":"OG001","spread":"12.0","value":"-0.6"},{"groupId":"OG002","spread":"12.4","value":"-2.5"},{"groupId":"OG003","spread":"13.3","value":"-2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.6","value":"-3.8"},{"groupId":"OG001","spread":"15.1","value":"-1.3"},{"groupId":"OG002","spread":"13.5","value":"-4.9"},{"groupId":"OG003","spread":"13.7","value":"-2.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.3","value":"-6.2"},{"groupId":"OG001","spread":"14.9","value":"-2.0"},{"groupId":"OG002","spread":"12.7","value":"-3.9"},{"groupId":"OG003","spread":"15.3","value":"-3.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.8","value":"-5.7"},{"groupId":"OG001","spread":"12.5","value":"-2.1"},{"groupId":"OG002","spread":"16.0","value":"-4.1"},{"groupId":"OG003","spread":"18.2","value":"-3.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.3","value":"-6.3"},{"groupId":"OG001","spread":"13.3","value":"-3.1"},{"groupId":"OG002","spread":"15.5","value":"-3.9"},{"groupId":"OG003","spread":"15.0","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.1","value":"-7.4"},{"groupId":"OG001","spread":"16.9","value":"-3.6"},{"groupId":"OG002","spread":"16.6","value":"-5.1"},{"groupId":"OG003","spread":"13.2","value":"-4.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.1","value":"-8.2"},{"groupId":"OG001","spread":"17.3","value":"-4.6"},{"groupId":"OG002","spread":"17.7","value":"-5.8"},{"groupId":"OG003","spread":"12.2","value":"-5.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.1","value":"-9.0"},{"groupId":"OG001","spread":"17.4","value":"-3.6"},{"groupId":"OG002","spread":"17.5","value":"-4.5"},{"groupId":"OG003","spread":"19.3","value":"-8.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.1","value":"-10.6"},{"groupId":"OG001","spread":"15.9","value":"-2.9"},{"groupId":"OG002","spread":"15.1","value":"-5.0"},{"groupId":"OG003","spread":"12.5","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"-8.7"},{"groupId":"OG001","spread":"14.6","value":"-4.0"},{"groupId":"OG002","spread":"13.6","value":"-3.9"},{"groupId":"OG003","spread":"14.5","value":"-4.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.7","value":"-7.7"},{"groupId":"OG001","spread":"16.1","value":"-3.9"},{"groupId":"OG002","spread":"15.7","value":"-6.5"},{"groupId":"OG003","spread":"12.7","value":"-5.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.3","value":"-4.9"},{"groupId":"OG001","spread":"19.5","value":"-3.5"},{"groupId":"OG002","spread":"17.2","value":"-4.0"},{"groupId":"OG003","spread":"14.3","value":"-6.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.9","value":"-4.4"},{"groupId":"OG001","spread":"14.1","value":"-1.6"},{"groupId":"OG002","spread":"14.0","value":"-1.5"},{"groupId":"OG003","spread":"14.1","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"-2.8"},{"groupId":"OG001","spread":"14.2","value":"-2.5"},{"groupId":"OG002","spread":"15.4","value":"-2.1"},{"groupId":"OG003","spread":"13.5","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.2","value":"-2.1"},{"groupId":"OG001","spread":"14.6","value":"-1.0"},{"groupId":"OG002","spread":"11.9","value":"-2.0"},{"groupId":"OG003","spread":"11.4","value":"-3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.3","value":"-3.5"},{"groupId":"OG001","spread":"9.1","value":"-1.9"},{"groupId":"OG002","spread":"13.0","value":"1.2"},{"groupId":"OG003","spread":"12.8","value":"-7.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.3","value":"-4.4"},{"groupId":"OG001","spread":"15.2","value":"-3.9"},{"groupId":"OG002","spread":"12.5","value":"-1.0"},{"groupId":"OG003","spread":"11.2","value":"-4.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.2","value":"-2.5"},{"groupId":"OG001","spread":"19.4","value":"-3.5"},{"groupId":"OG002","spread":"14.7","value":"-1.1"},{"groupId":"OG003","spread":"12.1","value":"-7.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"-2.5"},{"groupId":"OG001","spread":"15.9","value":"-2.3"},{"groupId":"OG002","spread":"11.3","value":"3.3"},{"groupId":"OG003","spread":"13.0","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.6","value":"1.2"},{"groupId":"OG001","spread":"16.9","value":"-4.0"},{"groupId":"OG002","spread":"13.1","value":"3.3"},{"groupId":"OG003","spread":"11.8","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.5","value":"1.5"},{"groupId":"OG001","spread":"10.2","value":"0.0"},{"groupId":"OG002","spread":"5.9","value":"-2.1"},{"groupId":"OG003","spread":"14.9","value":"-6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.1","value":"-3.9"},{"groupId":"OG001","spread":"15.0","value":"-1.4"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"14.9","value":"-6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.5","value":"4.8"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"11.8","value":"-8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"11.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"-16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.6","value":"16.7"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"11.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.5","value":"-2.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"8.6","value":"-5.6"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Cognitive Functioning: Change at PT/Discontin."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.6","value":"3.1"},{"groupId":"OG001","spread":"16.3","value":"5.7"},{"groupId":"OG002","spread":"12.6","value":"4.6"},{"groupId":"OG003","spread":"15.3","value":"5.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"146"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"88"}],"units":"Participants"}],"title":"Constipation: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.9","value":"-2.9"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"8.3","value":"-2.1"},{"groupId":"OG003","spread":"12.5","value":"-5.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.0","value":"2.1"},{"groupId":"OG001","spread":"13.0","value":"0.7"},{"groupId":"OG002","spread":"13.9","value":"1.7"},{"groupId":"OG003","spread":"16.9","value":"-0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"130"},{"groupId":"OG001","value":"138"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"83"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.7","value":"-1.6"},{"groupId":"OG001","spread":"7.3","value":"1.6"},{"groupId":"OG002","spread":"12.6","value":"0.0"},{"groupId":"OG003","spread":"16.2","value":"-3.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.7","value":"1.1"},{"groupId":"OG001","spread":"10.4","value":"1.4"},{"groupId":"OG002","spread":"13.8","value":"1.6"},{"groupId":"OG003","spread":"16.9","value":"-0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"124"},{"groupId":"OG001","value":"141"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"83"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.8","value":"1.4"},{"groupId":"OG001","spread":"13.0","value":"0.0"},{"groupId":"OG002","spread":"11.9","value":"0.0"},{"groupId":"OG003","spread":"15.5","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"117"},{"groupId":"OG001","value":"133"},{"groupId":"OG002","value":"79"},{"groupId":"OG003","value":"79"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.4","value":"-1.2"},{"groupId":"OG001","spread":"13.9","value":"1.0"},{"groupId":"OG002","spread":"12.5","value":"0.4"},{"groupId":"OG003","spread":"18.7","value":"-1.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"115"},{"groupId":"OG001","value":"127"},{"groupId":"OG002","value":"79"},{"groupId":"OG003","value":"77"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.5","value":"0.6"},{"groupId":"OG001","spread":"16.8","value":"0.5"},{"groupId":"OG002","spread":"10.7","value":"0.0"},{"groupId":"OG003","spread":"14.8","value":"-2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"118"},{"groupId":"OG001","value":"127"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.1","value":"-0.6"},{"groupId":"OG001","spread":"16.7","value":"0.3"},{"groupId":"OG002","spread":"14.4","value":"3.8"},{"groupId":"OG003","spread":"17.5","value":"-3.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"107"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"71"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.1","value":"0.6"},{"groupId":"OG001","spread":"16.6","value":"1.8"},{"groupId":"OG002","spread":"16.9","value":"5.4"},{"groupId":"OG003","spread":"20.0","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.1","value":"3.1"},{"groupId":"OG001","spread":"19.0","value":"1.5"},{"groupId":"OG002","spread":"12.6","value":"3.0"},{"groupId":"OG003","spread":"15.3","value":"-4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.6","value":"1.9"},{"groupId":"OG001","spread":"16.2","value":"1.6"},{"groupId":"OG002","spread":"15.1","value":"4.2"},{"groupId":"OG003","spread":"17.8","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"103"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"64"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.7","value":"1.4"},{"groupId":"OG001","spread":"13.5","value":"-2.3"},{"groupId":"OG002","spread":"14.4","value":"3.2"},{"groupId":"OG003","spread":"20.3","value":"-0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"97"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"62"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.7","value":"1.4"},{"groupId":"OG001","spread":"12.7","value":"-1.4"},{"groupId":"OG002","spread":"11.2","value":"1.6"},{"groupId":"OG003","spread":"17.9","value":"-4.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"62"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.7","value":"2.2"},{"groupId":"OG001","spread":"16.3","value":"0.0"},{"groupId":"OG002","spread":"14.0","value":"2.4"},{"groupId":"OG003","spread":"15.4","value":"-4.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"92"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.1","value":"4.8"},{"groupId":"OG001","spread":"14.4","value":"-1.8"},{"groupId":"OG002","spread":"13.4","value":"3.1"},{"groupId":"OG003","spread":"14.2","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.5","value":"4.1"},{"groupId":"OG001","spread":"18.8","value":"0.0"},{"groupId":"OG002","spread":"11.2","value":"0.0"},{"groupId":"OG003","spread":"19.1","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"81"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Constipation: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.1","value":"3.3"},{"groupId":"OG001","spread":"19.1","value":"2.4"},{"groupId":"OG002","spread":"17.3","value":"4.5"},{"groupId":"OG003","spread":"17.8","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"122"},{"groupId":"OG001","value":"124"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"74"}],"units":"Participants"}],"title":"Constipation: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.1","value":"0.4"},{"groupId":"OG001","spread":"17.0","value":"-0.5"},{"groupId":"OG002","spread":"16.9","value":"6.0"},{"groupId":"OG003","spread":"21.2","value":"0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"88"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Constipation: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.8","value":"-0.4"},{"groupId":"OG001","spread":"13.8","value":"-0.9"},{"groupId":"OG002","spread":"9.4","value":"2.8"},{"groupId":"OG003","spread":"18.9","value":"-1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"89"},{"groupId":"OG001","value":"71"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Constipation: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.8","value":"0.4"},{"groupId":"OG001","spread":"13.6","value":"-0.5"},{"groupId":"OG002","spread":"13.7","value":"2.4"},{"groupId":"OG003","spread":"16.2","value":"-4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"77"},{"groupId":"OG001","value":"67"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Constipation: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.4","value":"0.0"},{"groupId":"OG001","spread":"14.8","value":"0.0"},{"groupId":"OG002","spread":"9.2","value":"0.0"},{"groupId":"OG003","spread":"13.6","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"75"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Constipation: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.1","value":"3.8"},{"groupId":"OG001","spread":"21.9","value":"3.6"},{"groupId":"OG002","spread":"14.3","value":"2.0"},{"groupId":"OG003","spread":"11.4","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"37"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Constipation: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.8","value":"-1.4"},{"groupId":"OG001","spread":"25.6","value":"6.1"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Constipation: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.4","value":"-4.3"},{"groupId":"OG001","spread":"18.3","value":"6.0"},{"groupId":"OG002","spread":"8.6","value":"2.2"},{"groupId":"OG003","spread":"14.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"28"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Constipation: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.8","value":"1.3"},{"groupId":"OG001","spread":"14.7","value":"4.0"},{"groupId":"OG002","spread":"10.5","value":"-3.3"},{"groupId":"OG003","spread":"16.7","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Constipation: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.7","value":"-6.7"},{"groupId":"OG001","spread":"19.6","value":"9.8"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"14.9","value":"-6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"20"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Constipation: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.9","value":"-8.3"},{"groupId":"OG001","spread":"13.0","value":"5.6"},{"groupId":"OG002","spread":"23.6","value":"0.0"},{"groupId":"OG003","spread":"14.9","value":"-6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"16"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Constipation: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.3","value":"-9.5"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Constipation: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"-16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Constipation: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Constipation: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"-11.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Constipation: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Constipation: Change at PT/Discontinuation"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.0","value":"4.1"},{"groupId":"OG001","spread":"17.5","value":"5.4"},{"groupId":"OG002","spread":"13.9","value":"3.8"},{"groupId":"OG003","spread":"16.5","value":"4.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Diarrhoea: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.3","value":"4.2"},{"groupId":"OG001","spread":"10.3","value":"0.0"},{"groupId":"OG002","spread":"20.6","value":"-4.2"},{"groupId":"OG003","spread":"24.4","value":"-8.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.3","value":"2.5"},{"groupId":"OG001","spread":"14.7","value":"-0.7"},{"groupId":"OG002","spread":"19.4","value":"1.7"},{"groupId":"OG003","spread":"17.1","value":"-1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"77"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.8","value":"3.0"},{"groupId":"OG001","spread":"16.6","value":"-1.6"},{"groupId":"OG002","spread":"23.5","value":"-2.2"},{"groupId":"OG003","spread":"25.7","value":"-9.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.9","value":"1.3"},{"groupId":"OG001","spread":"16.3","value":"-0.9"},{"groupId":"OG002","spread":"21.7","value":"4.9"},{"groupId":"OG003","spread":"20.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.2","value":"1.7"},{"groupId":"OG001","spread":"19.1","value":"-1.5"},{"groupId":"OG002","spread":"17.2","value":"0.4"},{"groupId":"OG003","spread":"16.8","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"80"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.9","value":"3.4"},{"groupId":"OG001","spread":"18.4","value":"-0.3"},{"groupId":"OG002","spread":"19.4","value":"3.3"},{"groupId":"OG003","spread":"15.2","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.0","value":"3.9"},{"groupId":"OG001","spread":"19.8","value":"0.3"},{"groupId":"OG002","spread":"18.2","value":"5.6"},{"groupId":"OG003","spread":"18.7","value":"-2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.7","value":"7.6"},{"groupId":"OG001","spread":"20.3","value":"-1.4"},{"groupId":"OG002","spread":"20.0","value":"2.8"},{"groupId":"OG003","spread":"18.9","value":"-3.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.2","value":"7.2"},{"groupId":"OG001","spread":"20.0","value":"-0.6"},{"groupId":"OG002","spread":"24.8","value":"7.2"},{"groupId":"OG003","spread":"19.2","value":"-2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.2","value":"9.4"},{"groupId":"OG001","spread":"21.6","value":"-1.5"},{"groupId":"OG002","spread":"22.5","value":"4.9"},{"groupId":"OG003","spread":"18.0","value":"-4.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.6","value":"5.1"},{"groupId":"OG001","spread":"21.3","value":"-0.9"},{"groupId":"OG002","spread":"20.9","value":"5.6"},{"groupId":"OG003","spread":"16.5","value":"-3.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.0","value":"7.7"},{"groupId":"OG001","spread":"24.5","value":"0.7"},{"groupId":"OG002","spread":"19.5","value":"4.3"},{"groupId":"OG003","spread":"23.3","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"62"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.6","value":"6.9"},{"groupId":"OG001","spread":"22.3","value":"-0.3"},{"groupId":"OG002","spread":"23.8","value":"5.9"},{"groupId":"OG003","spread":"18.9","value":"-2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"62"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.6","value":"6.1"},{"groupId":"OG001","spread":"23.3","value":"1.1"},{"groupId":"OG002","spread":"23.1","value":"4.7"},{"groupId":"OG003","spread":"20.0","value":"-0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.4","value":"7.4"},{"groupId":"OG001","spread":"23.3","value":"-0.7"},{"groupId":"OG002","spread":"24.8","value":"7.9"},{"groupId":"OG003","spread":"19.0","value":"-0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.5","value":"8.5"},{"groupId":"OG001","spread":"25.4","value":"0.4"},{"groupId":"OG002","spread":"28.9","value":"8.0"},{"groupId":"OG003","spread":"20.0","value":"-1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Diarrhoea: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"0.8"},{"groupId":"OG001","spread":"20.7","value":"0.0"},{"groupId":"OG002","spread":"16.4","value":"-1.0"},{"groupId":"OG003","spread":"18.9","value":"-1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Diarrhoea: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.4","value":"-0.4"},{"groupId":"OG001","spread":"24.0","value":"-1.8"},{"groupId":"OG002","spread":"18.0","value":"0.0"},{"groupId":"OG003","spread":"15.5","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.5","value":"-2.2"},{"groupId":"OG001","spread":"24.5","value":"-3.2"},{"groupId":"OG002","spread":"8.5","value":"0.7"},{"groupId":"OG003","spread":"19.7","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"89"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.9","value":"-1.7"},{"groupId":"OG001","spread":"23.2","value":"-4.9"},{"groupId":"OG002","spread":"14.8","value":"1.6"},{"groupId":"OG003","spread":"18.6","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.2","value":"-1.8"},{"groupId":"OG001","spread":"23.5","value":"-3.8"},{"groupId":"OG002","spread":"21.6","value":"-1.2"},{"groupId":"OG003","spread":"19.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"75"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.6","value":"0.0"},{"groupId":"OG001","spread":"29.9","value":"-6.1"},{"groupId":"OG002","spread":"8.1","value":"2.0"},{"groupId":"OG003","spread":"24.4","value":"-7.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.5","value":"-0.7"},{"groupId":"OG001","spread":"29.8","value":"-7.1"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"11.1","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"4.0"},{"groupId":"OG001","spread":"25.0","value":"-9.2"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"28.9","value":"-8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.2","value":"0.0"},{"groupId":"OG001","spread":"28.3","value":"-5.3"},{"groupId":"OG002","spread":"10.5","value":"3.3"},{"groupId":"OG003","spread":"33.3","value":"-11.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.3","value":"0.0"},{"groupId":"OG001","spread":"31.0","value":"-11.8"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.1","value":"-2.0"},{"groupId":"OG001","spread":"43.7","value":"-2.8"},{"groupId":"OG002","spread":"14.9","value":"6.7"},{"groupId":"OG003","spread":"18.3","value":"13.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.8","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"-33.3"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Diarrhoea: Change at PT/Discontinuation"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.4","value":"3.6"},{"groupId":"OG001","spread":"12.9","value":"4.8"},{"groupId":"OG002","spread":"12.0","value":"5.0"},{"groupId":"OG003","spread":"10.8","value":"3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Dyspnoea: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.3","value":"4.2"},{"groupId":"OG001","spread":"7.1","value":"-1.5"},{"groupId":"OG002","spread":"16.7","value":"4.2"},{"groupId":"OG003","spread":"7.6","value":"-1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"6.3"},{"groupId":"OG001","spread":"8.5","value":"0.2"},{"groupId":"OG002","spread":"15.2","value":"2.9"},{"groupId":"OG003","spread":"12.1","value":"1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.0","value":"4.8"},{"groupId":"OG001","spread":"7.3","value":"-1.6"},{"groupId":"OG002","spread":"17.8","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.5","value":"1.9"},{"groupId":"OG001","spread":"11.6","value":"0.2"},{"groupId":"OG002","spread":"20.9","value":"4.8"},{"groupId":"OG003","spread":"14.3","value":"3.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"126"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.0","value":"2.8"},{"groupId":"OG001","spread":"13.5","value":"1.0"},{"groupId":"OG002","spread":"18.9","value":"4.6"},{"groupId":"OG003","spread":"17.0","value":"4.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.0","value":"3.4"},{"groupId":"OG001","spread":"13.4","value":"1.8"},{"groupId":"OG002","spread":"18.3","value":"3.7"},{"groupId":"OG003","spread":"12.0","value":"3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.6","value":"3.1"},{"groupId":"OG001","spread":"14.7","value":"3.1"},{"groupId":"OG002","spread":"18.8","value":"3.0"},{"groupId":"OG003","spread":"14.3","value":"1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.4","value":"5.2"},{"groupId":"OG001","spread":"14.7","value":"4.0"},{"groupId":"OG002","spread":"19.0","value":"3.7"},{"groupId":"OG003","spread":"15.4","value":"3.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.8","value":"3.8"},{"groupId":"OG001","spread":"13.9","value":"2.4"},{"groupId":"OG002","spread":"19.4","value":"3.9"},{"groupId":"OG003","spread":"15.7","value":"2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.7","value":"5.3"},{"groupId":"OG001","spread":"17.3","value":"3.7"},{"groupId":"OG002","spread":"17.8","value":"3.9"},{"groupId":"OG003","spread":"12.8","value":"2.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.5","value":"4.2"},{"groupId":"OG001","spread":"17.6","value":"4.1"},{"groupId":"OG002","spread":"14.8","value":"2.6"},{"groupId":"OG003","spread":"13.5","value":"3.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.1","value":"5.7"},{"groupId":"OG001","spread":"16.8","value":"5.3"},{"groupId":"OG002","spread":"16.8","value":"2.1"},{"groupId":"OG003","spread":"18.7","value":"4.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.1","value":"5.2"},{"groupId":"OG001","spread":"16.4","value":"4.5"},{"groupId":"OG002","spread":"18.8","value":"6.3"},{"groupId":"OG003","spread":"12.5","value":"3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.4","value":"5.7"},{"groupId":"OG001","spread":"19.0","value":"5.0"},{"groupId":"OG002","spread":"20.6","value":"7.0"},{"groupId":"OG003","spread":"14.2","value":"3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.1","value":"6.7"},{"groupId":"OG001","spread":"18.1","value":"5.5"},{"groupId":"OG002","spread":"18.9","value":"3.6"},{"groupId":"OG003","spread":"15.9","value":"5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"6.5"},{"groupId":"OG001","spread":"15.5","value":"4.9"},{"groupId":"OG002","spread":"19.9","value":"4.9"},{"groupId":"OG003","spread":"14.7","value":"5.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Dyspnoea: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.5","value":"4.1"},{"groupId":"OG001","spread":"19.9","value":"2.4"},{"groupId":"OG002","spread":"18.1","value":"3.0"},{"groupId":"OG003","spread":"16.2","value":"6.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Dyspnoea: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.1","value":"3.0"},{"groupId":"OG001","spread":"16.7","value":"3.2"},{"groupId":"OG002","spread":"16.1","value":"3.0"},{"groupId":"OG003","spread":"12.0","value":"2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"4.8"},{"groupId":"OG001","spread":"16.3","value":"1.4"},{"groupId":"OG002","spread":"19.9","value":"3.5"},{"groupId":"OG003","spread":"5.6","value":"-1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.0","value":"1.7"},{"groupId":"OG001","spread":"13.3","value":"2.5"},{"groupId":"OG002","spread":"18.9","value":"4.8"},{"groupId":"OG003","spread":"12.8","value":"3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.3","value":"1.8"},{"groupId":"OG001","spread":"16.1","value":"3.8"},{"groupId":"OG002","spread":"15.8","value":"2.5"},{"groupId":"OG003","spread":"15.8","value":"5.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.1","value":"3.8"},{"groupId":"OG001","spread":"15.2","value":"6.1"},{"groupId":"OG002","spread":"11.1","value":"-3.9"},{"groupId":"OG003","spread":"7.9","value":"1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.3","value":"4.3"},{"groupId":"OG001","spread":"18.2","value":"7.1"},{"groupId":"OG002","spread":"21.8","value":"0.0"},{"groupId":"OG003","spread":"16.7","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.7","value":"3.0"},{"groupId":"OG001","spread":"12.8","value":"5.7"},{"groupId":"OG002","spread":"15.3","value":"-2.2"},{"groupId":"OG003","spread":"14.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.0","value":"0.0"},{"groupId":"OG001","spread":"16.7","value":"6.7"},{"groupId":"OG002","spread":"22.2","value":"0.0"},{"groupId":"OG003","spread":"15.4","value":"8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"8"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.5","value":"0.0"},{"groupId":"OG001","spread":"13.1","value":"5.9"},{"groupId":"OG002","spread":"20.0","value":"-3.7"},{"groupId":"OG003","spread":"14.9","value":"6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.1","value":"-2.0"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"23.6","value":"0.0"},{"groupId":"OG003","spread":"18.3","value":"13.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.2","value":"9.5"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"19.2","value":"-11.1"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Dyspnoea: Change at PT/Discontinuation"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.1","value":"83.8"},{"groupId":"OG001","spread":"16.4","value":"86.1"},{"groupId":"OG002","spread":"21.5","value":"81.6"},{"groupId":"OG003","spread":"17.4","value":"84.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Emotional functioning: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.5","value":"-4.5"},{"groupId":"OG001","spread":"12.0","value":"1.9"},{"groupId":"OG002","spread":"11.4","value":"3.6"},{"groupId":"OG003","spread":"14.0","value":"1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.0","value":"-5.2"},{"groupId":"OG001","spread":"12.3","value":"1.9"},{"groupId":"OG002","spread":"16.6","value":"-1.0"},{"groupId":"OG003","spread":"12.0","value":"3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.6","value":"-6.4"},{"groupId":"OG001","spread":"9.9","value":"2.4"},{"groupId":"OG002","spread":"12.8","value":"-0.6"},{"groupId":"OG003","spread":"17.3","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.0","value":"-1.2"},{"groupId":"OG001","spread":"13.2","value":"2.5"},{"groupId":"OG002","spread":"17.5","value":"-1.0"},{"groupId":"OG003","spread":"12.7","value":"4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.7","value":"0.2"},{"groupId":"OG001","spread":"15.4","value":"2.0"},{"groupId":"OG002","spread":"11.7","value":"-0.5"},{"groupId":"OG003","spread":"13.6","value":"3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"80"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.3","value":"-0.1"},{"groupId":"OG001","spread":"13.2","value":"2.3"},{"groupId":"OG002","spread":"16.8","value":"-0.8"},{"groupId":"OG003","spread":"13.9","value":"3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"-2.7"},{"groupId":"OG001","spread":"15.1","value":"1.8"},{"groupId":"OG002","spread":"15.9","value":"-1.2"},{"groupId":"OG003","spread":"14.9","value":"2.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.8","value":"-3.5"},{"groupId":"OG001","spread":"18.4","value":"-0.2"},{"groupId":"OG002","spread":"15.4","value":"-0.8"},{"groupId":"OG003","spread":"14.4","value":"3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.5","value":"-2.8"},{"groupId":"OG001","spread":"16.7","value":"-0.7"},{"groupId":"OG002","spread":"16.0","value":"-2.6"},{"groupId":"OG003","spread":"18.7","value":"1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.5","value":"-3.0"},{"groupId":"OG001","spread":"16.4","value":"0.5"},{"groupId":"OG002","spread":"16.1","value":"-2.3"},{"groupId":"OG003","spread":"14.4","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.0","value":"-3.5"},{"groupId":"OG001","spread":"15.5","value":"-0.9"},{"groupId":"OG002","spread":"15.9","value":"-1.9"},{"groupId":"OG003","spread":"13.1","value":"0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.1","value":"-1.6"},{"groupId":"OG001","spread":"17.0","value":"-0.9"},{"groupId":"OG002","spread":"15.8","value":"0.1"},{"groupId":"OG003","spread":"16.1","value":"-0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.5","value":"-1.0"},{"groupId":"OG001","spread":"14.3","value":"-1.1"},{"groupId":"OG002","spread":"16.5","value":"-0.1"},{"groupId":"OG003","spread":"14.6","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.6","value":"0.0"},{"groupId":"OG001","spread":"14.1","value":"0.5"},{"groupId":"OG002","spread":"15.7","value":"1.2"},{"groupId":"OG003","spread":"14.3","value":"0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.0","value":"-2.3"},{"groupId":"OG001","spread":"16.4","value":"-2.2"},{"groupId":"OG002","spread":"14.6","value":"1.1"},{"groupId":"OG003","spread":"14.1","value":"-1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.4","value":"-2.0"},{"groupId":"OG001","spread":"18.6","value":"-2.5"},{"groupId":"OG002","spread":"16.5","value":"0.2"},{"groupId":"OG003","spread":"13.5","value":"0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Emotional functioning: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.8","value":"1.5"},{"groupId":"OG001","spread":"19.6","value":"-2.0"},{"groupId":"OG002","spread":"22.2","value":"2.2"},{"groupId":"OG003","spread":"19.9","value":"-4.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Emotional functioning: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.4","value":"3.2"},{"groupId":"OG001","spread":"19.5","value":"-1.0"},{"groupId":"OG002","spread":"16.7","value":"6.4"},{"groupId":"OG003","spread":"13.8","value":"3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.3","value":"4.9"},{"groupId":"OG001","spread":"14.1","value":"-1.4"},{"groupId":"OG002","spread":"18.2","value":"3.0"},{"groupId":"OG003","spread":"16.2","value":"1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.5","value":"2.5"},{"groupId":"OG001","spread":"14.9","value":"-0.2"},{"groupId":"OG002","spread":"19.0","value":"4.1"},{"groupId":"OG003","spread":"12.9","value":"2.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.8","value":"2.4"},{"groupId":"OG001","spread":"16.3","value":"-0.7"},{"groupId":"OG002","spread":"16.8","value":"9.0"},{"groupId":"OG003","spread":"14.2","value":"1.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.9","value":"1.1"},{"groupId":"OG001","spread":"17.5","value":"-2.0"},{"groupId":"OG002","spread":"17.1","value":"10.3"},{"groupId":"OG003","spread":"16.0","value":"3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.6","value":"2.9"},{"groupId":"OG001","spread":"22.1","value":"-1.8"},{"groupId":"OG002","spread":"16.2","value":"8.9"},{"groupId":"OG003","spread":"10.8","value":"1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.8","value":"1.8"},{"groupId":"OG001","spread":"17.3","value":"0.0"},{"groupId":"OG002","spread":"16.6","value":"13.3"},{"groupId":"OG003","spread":"20.6","value":"-0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.3","value":"6.5"},{"groupId":"OG001","spread":"21.9","value":"-7.0"},{"groupId":"OG002","spread":"13.2","value":"4.2"},{"groupId":"OG003","spread":"20.7","value":"1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.7","value":"7.2"},{"groupId":"OG001","spread":"14.7","value":"-2.9"},{"groupId":"OG002","spread":"16.7","value":"0.0"},{"groupId":"OG003","spread":"29.8","value":"3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.8","value":"8.7"},{"groupId":"OG001","spread":"15.3","value":"-4.9"},{"groupId":"OG002","spread":"20.1","value":"3.3"},{"groupId":"OG003","spread":"32.5","value":"1.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.0","value":"0.0"},{"groupId":"OG001","spread":"5.9","value":"-4.2"},{"groupId":"OG002","spread":"25.0","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"-16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.6","value":"22.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"53.0","value":"4.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.8","value":"25.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.7","value":"16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.1","value":"-5.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"11.1","value":"1.4"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Emotional functioning: Change at PT/Discont."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.7","value":"13.2"},{"groupId":"OG001","spread":"19.4","value":"16.1"},{"groupId":"OG002","spread":"18.2","value":"15.5"},{"groupId":"OG003","spread":"18.6","value":"14.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Fatigue: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.0","value":"7.9"},{"groupId":"OG001","spread":"9.8","value":"-0.3"},{"groupId":"OG002","spread":"13.3","value":"7.6"},{"groupId":"OG003","spread":"10.1","value":"5.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.1","value":"22.6"},{"groupId":"OG001","spread":"14.2","value":"2.3"},{"groupId":"OG002","spread":"27.0","value":"18.2"},{"groupId":"OG003","spread":"13.1","value":"3.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.3","value":"15.2"},{"groupId":"OG001","spread":"14.4","value":"-1.9"},{"groupId":"OG002","spread":"21.4","value":"17.0"},{"groupId":"OG003","spread":"15.8","value":"9.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.0","value":"13.2"},{"groupId":"OG001","spread":"15.2","value":"2.5"},{"groupId":"OG002","spread":"24.2","value":"13.7"},{"groupId":"OG003","spread":"14.5","value":"2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.5","value":"15.2"},{"groupId":"OG001","spread":"18.2","value":"1.5"},{"groupId":"OG002","spread":"19.9","value":"10.7"},{"groupId":"OG003","spread":"16.5","value":"2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.5","value":"14.1"},{"groupId":"OG001","spread":"16.4","value":"1.5"},{"groupId":"OG002","spread":"23.1","value":"12.6"},{"groupId":"OG003","spread":"15.9","value":"4.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.7","value":"12.6"},{"groupId":"OG001","spread":"18.4","value":"2.0"},{"groupId":"OG002","spread":"23.1","value":"13.3"},{"groupId":"OG003","spread":"18.1","value":"3.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.7","value":"14.2"},{"groupId":"OG001","spread":"16.1","value":"1.9"},{"groupId":"OG002","spread":"18.9","value":"13.6"},{"groupId":"OG003","spread":"17.2","value":"4.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.6","value":"11.9"},{"groupId":"OG001","spread":"17.4","value":"1.5"},{"groupId":"OG002","spread":"22.2","value":"13.8"},{"groupId":"OG003","spread":"18.7","value":"3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.0","value":"13.1"},{"groupId":"OG001","spread":"18.3","value":"0.2"},{"groupId":"OG002","spread":"23.2","value":"13.2"},{"groupId":"OG003","spread":"17.7","value":"6.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.9","value":"14.1"},{"groupId":"OG001","spread":"21.9","value":"3.9"},{"groupId":"OG002","spread":"22.7","value":"12.7"},{"groupId":"OG003","spread":"15.5","value":"5.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"105"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.3","value":"16.3"},{"groupId":"OG001","spread":"20.5","value":"2.7"},{"groupId":"OG002","spread":"24.1","value":"13.7"},{"groupId":"OG003","spread":"21.3","value":"6.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.6","value":"11.3"},{"groupId":"OG001","spread":"18.7","value":"3.4"},{"groupId":"OG002","spread":"25.0","value":"11.3"},{"groupId":"OG003","spread":"16.2","value":"3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.7","value":"11.5"},{"groupId":"OG001","spread":"18.2","value":"2.7"},{"groupId":"OG002","spread":"20.9","value":"10.7"},{"groupId":"OG003","spread":"18.4","value":"7.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.8","value":"10.3"},{"groupId":"OG001","spread":"16.2","value":"2.1"},{"groupId":"OG002","spread":"22.5","value":"10.7"},{"groupId":"OG003","spread":"17.0","value":"3.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.1","value":"11.1"},{"groupId":"OG001","spread":"19.0","value":"4.0"},{"groupId":"OG002","spread":"26.6","value":"13.4"},{"groupId":"OG003","spread":"15.6","value":"4.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Fatigue: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.3","value":"6.5"},{"groupId":"OG001","spread":"24.2","value":"2.2"},{"groupId":"OG002","spread":"21.9","value":"3.3"},{"groupId":"OG003","spread":"20.9","value":"6.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Fatigue: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.4","value":"1.6"},{"groupId":"OG001","spread":"19.8","value":"0.7"},{"groupId":"OG002","spread":"19.0","value":"-1.2"},{"groupId":"OG003","spread":"14.9","value":"1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Fatigue: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.4","value":"2.5"},{"groupId":"OG001","spread":"15.5","value":"1.0"},{"groupId":"OG002","spread":"21.6","value":"0.5"},{"groupId":"OG003","spread":"18.8","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Fatigue: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.9","value":"-1.0"},{"groupId":"OG001","spread":"17.2","value":"0.7"},{"groupId":"OG002","spread":"18.2","value":"-0.5"},{"groupId":"OG003","spread":"12.6","value":"-0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Fatigue: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.7","value":"1.6"},{"groupId":"OG001","spread":"17.6","value":"1.7"},{"groupId":"OG002","spread":"14.6","value":"-1.2"},{"groupId":"OG003","spread":"20.6","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Fatigue: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.5","value":"1.3"},{"groupId":"OG001","spread":"18.5","value":"4.4"},{"groupId":"OG002","spread":"11.8","value":"-4.6"},{"groupId":"OG003","spread":"17.8","value":"-1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Fatigue: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"2.4"},{"groupId":"OG001","spread":"20.8","value":"4.7"},{"groupId":"OG002","spread":"10.1","value":"-4.4"},{"groupId":"OG003","spread":"18.5","value":"-4.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Fatigue: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.3","value":"-0.8"},{"groupId":"OG001","spread":"18.8","value":"3.8"},{"groupId":"OG002","spread":"15.5","value":"-3.7"},{"groupId":"OG003","spread":"26.0","value":"-2.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Fatigue: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.6","value":"-1.2"},{"groupId":"OG001","spread":"18.7","value":"8.9"},{"groupId":"OG002","spread":"17.7","value":"-1.1"},{"groupId":"OG003","spread":"29.1","value":"-1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Fatigue: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.4","value":"-3.0"},{"groupId":"OG001","spread":"19.2","value":"4.2"},{"groupId":"OG002","spread":"15.7","value":"-7.4"},{"groupId":"OG003","spread":"28.3","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Fatigue: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.5","value":"-0.7"},{"groupId":"OG001","spread":"19.2","value":"6.5"},{"groupId":"OG002","spread":"16.9","value":"-4.4"},{"groupId":"OG003","spread":"33.3","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Fatigue: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.9","value":"-1.6"},{"groupId":"OG001","spread":"7.9","value":"5.6"},{"groupId":"OG002","spread":"17.0","value":"-3.7"},{"groupId":"OG003","spread":"23.6","value":"16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Fatigue: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.1","value":"-11.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"15.7","value":"33.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Fatigue: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.9","value":"-16.7"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Fatigue: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.4","value":"-14.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Fatigue: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.7","value":"6.9"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"-22.2"},{"groupId":"OG002","spread":"25.3","value":"-11.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Fatigue: Change at PT/Discontinuation"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.2","value":"12.4"},{"groupId":"OG001","spread":"30.0","value":"20.9"},{"groupId":"OG002","spread":"30.4","value":"16.5"},{"groupId":"OG003","spread":"26.3","value":"15.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"137"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"88"}],"units":"Participants"}],"title":"Financial difficulties: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.0","value":"-9.7"},{"groupId":"OG001","spread":"14.2","value":"-3.0"},{"groupId":"OG002","spread":"8.3","value":"2.1"},{"groupId":"OG003","spread":"17.8","value":"-7.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.5","value":"1.5"},{"groupId":"OG001","spread":"20.0","value":"-1.9"},{"groupId":"OG002","spread":"15.2","value":"0.0"},{"groupId":"OG003","spread":"21.2","value":"-4.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"131"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.2","value":"-1.5"},{"groupId":"OG001","spread":"14.5","value":"-3.2"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"20.4","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.9","value":"0.0"},{"groupId":"OG001","spread":"21.0","value":"-3.1"},{"groupId":"OG002","spread":"16.5","value":"0.8"},{"groupId":"OG003","spread":"19.3","value":"-4.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"126"},{"groupId":"OG001","value":"141"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"83"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.8","value":"1.1"},{"groupId":"OG001","spread":"20.1","value":"-2.2"},{"groupId":"OG002","spread":"17.2","value":"-0.4"},{"groupId":"OG003","spread":"20.4","value":"-7.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"79"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"0.3"},{"groupId":"OG001","spread":"24.1","value":"-5.2"},{"groupId":"OG002","spread":"20.2","value":"1.3"},{"groupId":"OG003","spread":"19.8","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"77"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.6","value":"-0.8"},{"groupId":"OG001","spread":"24.3","value":"-2.8"},{"groupId":"OG002","spread":"19.7","value":"-0.4"},{"groupId":"OG003","spread":"18.5","value":"-5.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.0","value":"1.2"},{"groupId":"OG001","spread":"26.7","value":"-5.5"},{"groupId":"OG002","spread":"18.0","value":"2.3"},{"groupId":"OG003","spread":"23.6","value":"-7.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.5","value":"-0.6"},{"groupId":"OG001","spread":"26.4","value":"-7.4"},{"groupId":"OG002","spread":"20.4","value":"2.9"},{"groupId":"OG003","spread":"22.0","value":"-5.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.8","value":"1.9"},{"groupId":"OG001","spread":"26.1","value":"-5.6"},{"groupId":"OG002","spread":"27.2","value":"4.9"},{"groupId":"OG003","spread":"21.6","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"107"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.2","value":"-0.6"},{"groupId":"OG001","spread":"27.0","value":"-4.7"},{"groupId":"OG002","spread":"26.7","value":"4.1"},{"groupId":"OG003","spread":"20.9","value":"-3.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.1","value":"2.0"},{"groupId":"OG001","spread":"23.0","value":"-8.9"},{"groupId":"OG002","spread":"23.6","value":"4.2"},{"groupId":"OG003","spread":"20.6","value":"-5.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.4","value":"1.0"},{"groupId":"OG001","spread":"25.1","value":"-8.6"},{"groupId":"OG002","spread":"22.6","value":"2.6"},{"groupId":"OG003","spread":"20.4","value":"-6.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.4","value":"1.4"},{"groupId":"OG001","spread":"21.5","value":"-7.5"},{"groupId":"OG002","spread":"20.4","value":"0.6"},{"groupId":"OG003","spread":"22.3","value":"-8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.4","value":"-0.4"},{"groupId":"OG001","spread":"23.9","value":"-6.3"},{"groupId":"OG002","spread":"26.4","value":"0.0"},{"groupId":"OG003","spread":"23.5","value":"-6.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"89"},{"groupId":"OG001","value":"90"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.7","value":"1.2"},{"groupId":"OG001","spread":"22.2","value":"-6.0"},{"groupId":"OG002","spread":"27.8","value":"-1.9"},{"groupId":"OG003","spread":"24.8","value":"-8.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Financial difficulties: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.1","value":"2.5"},{"groupId":"OG001","spread":"26.5","value":"-3.7"},{"groupId":"OG002","spread":"23.4","value":"-2.5"},{"groupId":"OG003","spread":"23.9","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"122"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Financial difficulties: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.2","value":"0.4"},{"groupId":"OG001","spread":"24.3","value":"-5.9"},{"groupId":"OG002","spread":"27.6","value":"-10.1"},{"groupId":"OG003","spread":"25.3","value":"-8.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.3","value":"-3.0"},{"groupId":"OG001","spread":"18.8","value":"-6.0"},{"groupId":"OG002","spread":"26.3","value":"-5.7"},{"groupId":"OG003","spread":"25.7","value":"-7.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"89"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.1","value":"-1.7"},{"groupId":"OG001","spread":"25.8","value":"-7.8"},{"groupId":"OG002","spread":"28.3","value":"-2.4"},{"groupId":"OG003","spread":"26.4","value":"-8.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"78"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"-2.2"},{"groupId":"OG001","spread":"21.1","value":"-5.4"},{"groupId":"OG002","spread":"24.5","value":"-11.1"},{"groupId":"OG003","spread":"32.6","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"75"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.3","value":"2.6"},{"groupId":"OG001","spread":"30.9","value":"-6.1"},{"groupId":"OG002","spread":"19.6","value":"-9.8"},{"groupId":"OG003","spread":"31.4","value":"-7.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"52"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.9","value":"2.2"},{"groupId":"OG001","spread":"31.2","value":"-8.1"},{"groupId":"OG002","spread":"20.6","value":"-11.1"},{"groupId":"OG003","spread":"16.7","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"45"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.2","value":"0.0"},{"groupId":"OG001","spread":"29.7","value":"-10.3"},{"groupId":"OG002","spread":"20.6","value":"-11.1"},{"groupId":"OG003","spread":"32.8","value":"-11.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"31"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.7","value":"-2.6"},{"groupId":"OG001","spread":"30.9","value":"-8.0"},{"groupId":"OG002","spread":"23.3","value":"-13.3"},{"groupId":"OG003","spread":"37.7","value":"-18.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"26"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.1","value":"-6.1"},{"groupId":"OG001","spread":"24.3","value":"-5.9"},{"groupId":"OG002","spread":"11.8","value":"-4.2"},{"groupId":"OG003","spread":"18.3","value":"-13.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.7","value":"-7.8"},{"groupId":"OG001","spread":"31.2","value":"-5.6"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"29.8","value":"-20.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"40.5","value":"4.8"},{"groupId":"OG001","spread":"23.6","value":"16.7"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"38.5","value":"-22.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"-16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"38.5","value":"-22.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.8","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Financial difficulties: Change at PT/Discontin."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.1","value":"1.4"},{"groupId":"OG001","spread":"9.6","value":"1.8"},{"groupId":"OG002","spread":"7.4","value":"1.9"},{"groupId":"OG003","spread":"5.2","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Nausea and vomiting: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.9","value":"4.2"},{"groupId":"OG001","spread":"6.3","value":"0.8"},{"groupId":"OG002","spread":"8.0","value":"5.2"},{"groupId":"OG003","spread":"8.9","value":"3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.9","value":"9.8"},{"groupId":"OG001","spread":"6.9","value":"1.8"},{"groupId":"OG002","spread":"17.0","value":"8.8"},{"groupId":"OG003","spread":"7.7","value":"1.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.1","value":"6.1"},{"groupId":"OG001","spread":"6.4","value":"0.8"},{"groupId":"OG002","spread":"10.3","value":"5.6"},{"groupId":"OG003","spread":"8.8","value":"2.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.9","value":"5.2"},{"groupId":"OG001","spread":"5.9","value":"0.9"},{"groupId":"OG002","spread":"11.1","value":"4.6"},{"groupId":"OG003","spread":"7.9","value":"1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.1","value":"6.3"},{"groupId":"OG001","spread":"8.5","value":"1.1"},{"groupId":"OG002","spread":"9.1","value":"2.9"},{"groupId":"OG003","spread":"10.4","value":"1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.1","value":"5.7"},{"groupId":"OG001","spread":"7.3","value":"1.6"},{"groupId":"OG002","spread":"9.9","value":"4.5"},{"groupId":"OG003","spread":"8.4","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.6","value":"5.6"},{"groupId":"OG001","spread":"11.7","value":"1.9"},{"groupId":"OG002","spread":"14.3","value":"6.6"},{"groupId":"OG003","spread":"10.8","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.4","value":"7.3"},{"groupId":"OG001","spread":"9.2","value":"2.6"},{"groupId":"OG002","spread":"10.7","value":"5.1"},{"groupId":"OG003","spread":"7.8","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.1","value":"5.3"},{"groupId":"OG001","spread":"9.7","value":"2.4"},{"groupId":"OG002","spread":"12.2","value":"6.3"},{"groupId":"OG003","spread":"7.9","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.7","value":"4.7"},{"groupId":"OG001","spread":"7.8","value":"2.0"},{"groupId":"OG002","spread":"11.3","value":"4.2"},{"groupId":"OG003","spread":"6.9","value":"0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.9","value":"4.6"},{"groupId":"OG001","spread":"9.0","value":"1.1"},{"groupId":"OG002","spread":"15.7","value":"5.9"},{"groupId":"OG003","spread":"12.4","value":"2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"105"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.7","value":"5.5"},{"groupId":"OG001","spread":"10.4","value":"2.5"},{"groupId":"OG002","spread":"10.2","value":"4.0"},{"groupId":"OG003","spread":"7.0","value":"0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.1","value":"5.2"},{"groupId":"OG001","spread":"10.3","value":"0.9"},{"groupId":"OG002","spread":"10.6","value":"4.8"},{"groupId":"OG003","spread":"6.5","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.9","value":"3.4"},{"groupId":"OG001","spread":"8.5","value":"2.0"},{"groupId":"OG002","spread":"8.6","value":"3.2"},{"groupId":"OG003","spread":"5.4","value":"-0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.6","value":"4.3"},{"groupId":"OG001","spread":"7.9","value":"1.3"},{"groupId":"OG002","spread":"10.5","value":"4.8"},{"groupId":"OG003","spread":"13.7","value":"3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.7","value":"2.8"},{"groupId":"OG001","spread":"7.1","value":"1.7"},{"groupId":"OG002","spread":"9.9","value":"3.4"},{"groupId":"OG003","spread":"9.8","value":"2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.5","value":"0.9"},{"groupId":"OG001","spread":"12.5","value":"0.3"},{"groupId":"OG002","spread":"11.9","value":"1.5"},{"groupId":"OG003","spread":"13.9","value":"3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.4","value":"0.2"},{"groupId":"OG001","spread":"8.5","value":"1.8"},{"groupId":"OG002","spread":"6.3","value":"0.6"},{"groupId":"OG003","spread":"6.7","value":"0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.7","value":"2.2"},{"groupId":"OG001","spread":"15.7","value":"0.7"},{"groupId":"OG002","spread":"10.4","value":"0.7"},{"groupId":"OG003","spread":"3.9","value":"-1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.7","value":"0.2"},{"groupId":"OG001","spread":"6.1","value":"0.2"},{"groupId":"OG002","spread":"8.1","value":"1.6"},{"groupId":"OG003","spread":"6.4","value":"1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.0","value":"0.9"},{"groupId":"OG001","spread":"4.8","value":"0.3"},{"groupId":"OG002","spread":"4.6","value":"0.0"},{"groupId":"OG003","spread":"3.3","value":"0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.7","value":"0.0"},{"groupId":"OG001","spread":"12.9","value":"3.5"},{"groupId":"OG002","spread":"4.0","value":"-1.0"},{"groupId":"OG003","spread":"8.6","value":"2.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.5","value":"0.4"},{"groupId":"OG001","spread":"11.6","value":"2.0"},{"groupId":"OG002","spread":"4.3","value":"-1.1"},{"groupId":"OG003","spread":"5.6","value":"1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.5","value":"1.6"},{"groupId":"OG001","spread":"8.6","value":"2.3"},{"groupId":"OG002","spread":"4.3","value":"-1.1"},{"groupId":"OG003","spread":"4.8","value":"1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.7","value":"1.9"},{"groupId":"OG001","spread":"4.8","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.9","value":"-1.5"},{"groupId":"OG001","spread":"9.8","value":"4.9"},{"groupId":"OG002","spread":"5.6","value":"-1.9"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"5.9","value":"0.0"},{"groupId":"OG001","spread":"10.4","value":"4.2"},{"groupId":"OG002","spread":"7.5","value":"-3.3"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"6.3","value":"-2.4"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"11.8","value":"8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.8","value":"4.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"13.9","value":"8.3"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Nausea and vomiting: Change at PT/Discont."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.5","value":"11.6"},{"groupId":"OG001","spread":"21.6","value":"12.8"},{"groupId":"OG002","spread":"19.0","value":"10.9"},{"groupId":"OG003","spread":"23.9","value":"14.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Pain: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.5","value":"9.7"},{"groupId":"OG001","spread":"15.4","value":"-1.5"},{"groupId":"OG002","spread":"14.8","value":"10.4"},{"groupId":"OG003","spread":"8.9","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Pain: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.5","value":"20.8"},{"groupId":"OG001","spread":"12.4","value":"0.5"},{"groupId":"OG002","spread":"28.1","value":"16.3"},{"groupId":"OG003","spread":"14.7","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Pain: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.9","value":"15.9"},{"groupId":"OG001","spread":"13.6","value":"-3.2"},{"groupId":"OG002","spread":"18.5","value":"22.2"},{"groupId":"OG003","spread":"21.3","value":"9.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Pain: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.5","value":"12.9"},{"groupId":"OG001","spread":"15.1","value":"0.5"},{"groupId":"OG002","spread":"28.9","value":"15.1"},{"groupId":"OG003","spread":"18.0","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Pain: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.5","value":"14.3"},{"groupId":"OG001","spread":"17.2","value":"2.4"},{"groupId":"OG002","spread":"23.3","value":"12.7"},{"groupId":"OG003","spread":"18.0","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Pain: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.2","value":"11.8"},{"groupId":"OG001","spread":"16.3","value":"1.2"},{"groupId":"OG002","spread":"25.6","value":"13.2"},{"groupId":"OG003","spread":"17.1","value":"-0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Pain: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.1","value":"9.0"},{"groupId":"OG001","spread":"19.7","value":"4.0"},{"groupId":"OG002","spread":"25.9","value":"12.0"},{"groupId":"OG003","spread":"19.6","value":"-2.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Pain: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.3","value":"12.7"},{"groupId":"OG001","spread":"17.6","value":"1.9"},{"groupId":"OG002","spread":"21.1","value":"14.6"},{"groupId":"OG003","spread":"20.5","value":"-4.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Pain: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.7","value":"8.8"},{"groupId":"OG001","spread":"18.9","value":"2.2"},{"groupId":"OG002","spread":"22.9","value":"14.5"},{"groupId":"OG003","spread":"20.0","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Pain: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.4","value":"8.2"},{"groupId":"OG001","spread":"16.6","value":"0.9"},{"groupId":"OG002","spread":"20.5","value":"8.3"},{"groupId":"OG003","spread":"19.1","value":"-2.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Pain: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.9","value":"11.0"},{"groupId":"OG001","spread":"20.1","value":"3.6"},{"groupId":"OG002","spread":"23.7","value":"12.1"},{"groupId":"OG003","spread":"18.3","value":"-1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"105"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Pain: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.5","value":"12.8"},{"groupId":"OG001","spread":"21.2","value":"3.6"},{"groupId":"OG002","spread":"23.5","value":"10.3"},{"groupId":"OG003","spread":"23.9","value":"-0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Pain: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.0","value":"8.9"},{"groupId":"OG001","spread":"17.5","value":"1.9"},{"groupId":"OG002","spread":"24.6","value":"11.6"},{"groupId":"OG003","spread":"16.9","value":"-3.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Pain: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.0","value":"10.0"},{"groupId":"OG001","spread":"21.3","value":"2.7"},{"groupId":"OG002","spread":"26.1","value":"13.5"},{"groupId":"OG003","spread":"24.3","value":"-0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Pain: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.6","value":"12.2"},{"groupId":"OG001","spread":"19.8","value":"1.3"},{"groupId":"OG002","spread":"19.5","value":"12.7"},{"groupId":"OG003","spread":"20.2","value":"-2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Pain: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.5","value":"11.6"},{"groupId":"OG001","spread":"21.2","value":"3.4"},{"groupId":"OG002","spread":"27.4","value":"16.4"},{"groupId":"OG003","spread":"22.0","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Pain: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.4","value":"4.9"},{"groupId":"OG001","spread":"23.3","value":"4.1"},{"groupId":"OG002","spread":"21.1","value":"6.7"},{"groupId":"OG003","spread":"21.4","value":"1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Pain: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.6","value":"-0.6"},{"groupId":"OG001","spread":"18.2","value":"-0.2"},{"groupId":"OG002","spread":"19.7","value":"4.2"},{"groupId":"OG003","spread":"23.5","value":"-4.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Pain: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.8","value":"1.1"},{"groupId":"OG001","spread":"16.6","value":"-1.2"},{"groupId":"OG002","spread":"24.0","value":"7.1"},{"groupId":"OG003","spread":"19.5","value":"-4.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Pain: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.9","value":"0.6"},{"groupId":"OG001","spread":"22.1","value":"2.2"},{"groupId":"OG002","spread":"23.0","value":"7.5"},{"groupId":"OG003","spread":"23.2","value":"-7.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Pain: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.0","value":"2.0"},{"groupId":"OG001","spread":"16.3","value":"0.0"},{"groupId":"OG002","spread":"21.8","value":"9.3"},{"groupId":"OG003","spread":"20.4","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Pain: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.7","value":"-0.3"},{"groupId":"OG001","spread":"21.2","value":"0.9"},{"groupId":"OG002","spread":"15.7","value":"6.9"},{"groupId":"OG003","spread":"12.5","value":"-4.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Pain: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.2","value":"0.7"},{"groupId":"OG001","spread":"19.6","value":"2.5"},{"groupId":"OG002","spread":"14.7","value":"1.1"},{"groupId":"OG003","spread":"8.3","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Pain: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.7","value":"-2.5"},{"groupId":"OG001","spread":"25.9","value":"4.6"},{"groupId":"OG002","spread":"14.7","value":"4.4"},{"groupId":"OG003","spread":"21.9","value":"-9.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Pain: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.9","value":"-1.2"},{"groupId":"OG001","spread":"22.4","value":"11.3"},{"groupId":"OG002","spread":"13.1","value":"3.3"},{"groupId":"OG003","spread":"21.7","value":"-13.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Pain: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.0","value":"-4.5"},{"groupId":"OG001","spread":"22.9","value":"8.8"},{"groupId":"OG002","spread":"13.0","value":"1.9"},{"groupId":"OG003","spread":"25.3","value":"-10.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Pain: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.8","value":"2.9"},{"groupId":"OG001","spread":"31.3","value":"6.9"},{"groupId":"OG002","spread":"27.9","value":"6.7"},{"groupId":"OG003","spread":"32.1","value":"-13.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Pain: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.2","value":"-2.4"},{"groupId":"OG001","spread":"11.8","value":"8.3"},{"groupId":"OG002","spread":"25.5","value":"5.6"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Pain: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"-22.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"11.8","value":"8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Pain: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.8","value":"-8.3"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Pain: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"-22.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Pain: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.8","value":"12.5"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"-33.3"},{"groupId":"OG002","spread":"19.5","value":"-2.8"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Pain: Change at PT/Discontin."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.0","value":"92.7"},{"groupId":"OG001","spread":"11.6","value":"92.3"},{"groupId":"OG002","spread":"13.6","value":"91.3"},{"groupId":"OG003","spread":"13.1","value":"92.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Physical functioning: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.7","value":"-4.4"},{"groupId":"OG001","spread":"4.4","value":"0.3"},{"groupId":"OG002","spread":"6.7","value":"-5.0"},{"groupId":"OG003","spread":"11.6","value":"-2.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.4","value":"-9.7"},{"groupId":"OG001","spread":"8.2","value":"-0.2"},{"groupId":"OG002","spread":"15.0","value":"-7.4"},{"groupId":"OG003","spread":"6.5","value":"-1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.6","value":"-10.3"},{"groupId":"OG001","spread":"7.0","value":"-0.6"},{"groupId":"OG002","spread":"15.3","value":"-10.2"},{"groupId":"OG003","spread":"9.7","value":"-2.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.4","value":"-6.2"},{"groupId":"OG001","spread":"9.1","value":"-0.3"},{"groupId":"OG002","spread":"16.9","value":"-9.2"},{"groupId":"OG003","spread":"8.2","value":"-1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.4","value":"-7.1"},{"groupId":"OG001","spread":"10.8","value":"-0.7"},{"groupId":"OG002","spread":"13.9","value":"-7.6"},{"groupId":"OG003","spread":"9.4","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.8","value":"-6.6"},{"groupId":"OG001","spread":"11.0","value":"-0.7"},{"groupId":"OG002","spread":"15.0","value":"-7.3"},{"groupId":"OG003","spread":"10.4","value":"-2.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.1","value":"-4.9"},{"groupId":"OG001","spread":"10.8","value":"-0.2"},{"groupId":"OG002","spread":"13.8","value":"-7.4"},{"groupId":"OG003","spread":"10.3","value":"-1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.7","value":"-6.1"},{"groupId":"OG001","spread":"11.3","value":"-1.0"},{"groupId":"OG002","spread":"13.3","value":"-5.6"},{"groupId":"OG003","spread":"12.7","value":"-1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.5","value":"-4.7"},{"groupId":"OG001","spread":"12.1","value":"-0.8"},{"groupId":"OG002","spread":"15.2","value":"-7.5"},{"groupId":"OG003","spread":"10.0","value":"-0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.6","value":"-4.7"},{"groupId":"OG001","spread":"11.2","value":"0.4"},{"groupId":"OG002","spread":"12.7","value":"-8.0"},{"groupId":"OG003","spread":"9.5","value":"0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.6","value":"-5.2"},{"groupId":"OG001","spread":"13.1","value":"-0.8"},{"groupId":"OG002","spread":"12.6","value":"-6.7"},{"groupId":"OG003","spread":"11.0","value":"-0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"105"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.2","value":"-6.7"},{"groupId":"OG001","spread":"12.2","value":"-0.5"},{"groupId":"OG002","spread":"10.6","value":"-5.5"},{"groupId":"OG003","spread":"14.7","value":"-1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.0","value":"-4.9"},{"groupId":"OG001","spread":"11.8","value":"-1.6"},{"groupId":"OG002","spread":"13.2","value":"-6.5"},{"groupId":"OG003","spread":"9.9","value":"-1.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.4","value":"-4.2"},{"groupId":"OG001","spread":"10.8","value":"-1.3"},{"groupId":"OG002","spread":"12.8","value":"-6.0"},{"groupId":"OG003","spread":"13.5","value":"-3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.7","value":"-5.4"},{"groupId":"OG001","spread":"11.5","value":"-1.6"},{"groupId":"OG002","spread":"11.9","value":"-4.8"},{"groupId":"OG003","spread":"10.8","value":"-0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.0","value":"-4.5"},{"groupId":"OG001","spread":"14.7","value":"-3.0"},{"groupId":"OG002","spread":"12.4","value":"-5.6"},{"groupId":"OG003","spread":"12.3","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Physical functioning: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"13.3","value":"-2.8"},{"groupId":"OG001","spread":"16.0","value":"-2.9"},{"groupId":"OG002","spread":"13.8","value":"-5.8"},{"groupId":"OG003","spread":"14.7","value":"-5.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Physical functioning: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.3","value":"0.5"},{"groupId":"OG001","spread":"9.8","value":"0.1"},{"groupId":"OG002","spread":"10.9","value":"-0.8"},{"groupId":"OG003","spread":"12.6","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.5","value":"-1.9"},{"groupId":"OG001","spread":"8.5","value":"0.0"},{"groupId":"OG002","spread":"10.5","value":"-4.1"},{"groupId":"OG003","spread":"12.6","value":"0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.7","value":"0.4"},{"groupId":"OG001","spread":"13.5","value":"-1.7"},{"groupId":"OG002","spread":"13.4","value":"-3.3"},{"groupId":"OG003","spread":"8.1","value":"0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"10.0","value":"-1.4"},{"groupId":"OG001","spread":"11.7","value":"-0.5"},{"groupId":"OG002","spread":"9.6","value":"-1.4"},{"groupId":"OG003","spread":"14.2","value":"-1.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.6","value":"-0.9"},{"groupId":"OG001","spread":"13.6","value":"-2.6"},{"groupId":"OG002","spread":"9.7","value":"2.7"},{"groupId":"OG003","spread":"10.3","value":"-0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.6","value":"-0.5"},{"groupId":"OG001","spread":"10.8","value":"-1.0"},{"groupId":"OG002","spread":"10.0","value":"2.7"},{"groupId":"OG003","spread":"11.6","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.2","value":"0.2"},{"groupId":"OG001","spread":"12.9","value":"-3.4"},{"groupId":"OG002","spread":"10.3","value":"-0.9"},{"groupId":"OG003","spread":"17.5","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.3","value":"2.5"},{"groupId":"OG001","spread":"10.3","value":"-4.9"},{"groupId":"OG002","spread":"11.2","value":"1.3"},{"groupId":"OG003","spread":"18.2","value":"1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.1","value":"1.2"},{"groupId":"OG001","spread":"14.2","value":"-7.1"},{"groupId":"OG002","spread":"13.1","value":"0.7"},{"groupId":"OG003","spread":"19.2","value":"2.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.2","value":"-1.2"},{"groupId":"OG001","spread":"11.4","value":"-5.0"},{"groupId":"OG002","spread":"10.1","value":"-2.7"},{"groupId":"OG003","spread":"20.2","value":"5.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.6","value":"0.0"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"20.4","value":"-4.4"},{"groupId":"OG003","spread":"4.7","value":"-3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.8","value":"2.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"9.4","value":"-6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.7","value":"3.3"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"3.8","value":"2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Physical functioning: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"8.3","value":"-0.8"},{"comment":"1 participant was analyzed, so standard deviation is not applicable","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"15.6","value":"10.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Physical functioning: Change at PT/Discontin."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.7","value":"79.0"},{"groupId":"OG001","spread":"18.4","value":"77.9"},{"groupId":"OG002","spread":"20.6","value":"76.5"},{"groupId":"OG003","spread":"17.6","value":"78.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Global health status/QoL: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.5","value":"-9.4"},{"groupId":"OG001","spread":"7.5","value":"0.4"},{"groupId":"OG002","spread":"15.9","value":"-9.9"},{"groupId":"OG003","spread":"6.4","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.2","value":"-19.1"},{"groupId":"OG001","spread":"11.4","value":"-0.4"},{"groupId":"OG002","spread":"20.4","value":"-14.5"},{"groupId":"OG003","spread":"11.7","value":"-0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"83"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.0","value":"-17.8"},{"groupId":"OG001","spread":"10.3","value":"1.2"},{"groupId":"OG002","spread":"19.9","value":"-16.7"},{"groupId":"OG003","spread":"11.2","value":"0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.7","value":"-9.8"},{"groupId":"OG001","spread":"14.5","value":"-1.2"},{"groupId":"OG002","spread":"17.6","value":"-10.9"},{"groupId":"OG003","spread":"10.8","value":"1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.0","value":"-11.5"},{"groupId":"OG001","spread":"13.5","value":"0.2"},{"groupId":"OG002","spread":"18.0","value":"-9.5"},{"groupId":"OG003","spread":"14.4","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"118"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"80"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.0","value":"-10.6"},{"groupId":"OG001","spread":"14.6","value":"-1.0"},{"groupId":"OG002","spread":"17.0","value":"-9.4"},{"groupId":"OG003","spread":"14.6","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.6","value":"-10.2"},{"groupId":"OG001","spread":"14.9","value":"-1.0"},{"groupId":"OG002","spread":"18.9","value":"-8.4"},{"groupId":"OG003","spread":"15.4","value":"-1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.4","value":"-12.0"},{"groupId":"OG001","spread":"15.1","value":"-0.1"},{"groupId":"OG002","spread":"17.3","value":"-8.9"},{"groupId":"OG003","spread":"16.6","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"-8.9"},{"groupId":"OG001","spread":"16.1","value":"-2.2"},{"groupId":"OG002","spread":"19.3","value":"-12.4"},{"groupId":"OG003","spread":"16.5","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.4","value":"-10.7"},{"groupId":"OG001","spread":"16.8","value":"-1.6"},{"groupId":"OG002","spread":"17.9","value":"-11.8"},{"groupId":"OG003","spread":"15.8","value":"-2.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.3","value":"-10.3"},{"groupId":"OG001","spread":"17.6","value":"-1.6"},{"groupId":"OG002","spread":"20.5","value":"-11.2"},{"groupId":"OG003","spread":"17.0","value":"-3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.9","value":"-11.3"},{"groupId":"OG001","spread":"16.9","value":"-0.5"},{"groupId":"OG002","spread":"19.7","value":"-8.3"},{"groupId":"OG003","spread":"16.6","value":"-1.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.1","value":"-7.6"},{"groupId":"OG001","spread":"15.9","value":"-0.7"},{"groupId":"OG002","spread":"18.7","value":"-9.8"},{"groupId":"OG003","spread":"15.0","value":"0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.5","value":"-7.8"},{"groupId":"OG001","spread":"15.3","value":"-0.8"},{"groupId":"OG002","spread":"18.9","value":"-8.8"},{"groupId":"OG003","spread":"18.2","value":"-3.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.2","value":"-9.3"},{"groupId":"OG001","spread":"16.0","value":"-0.8"},{"groupId":"OG002","spread":"17.4","value":"-10.5"},{"groupId":"OG003","spread":"18.0","value":"-3.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.5","value":"-7.5"},{"groupId":"OG001","spread":"19.4","value":"-3.4"},{"groupId":"OG002","spread":"18.9","value":"-9.4"},{"groupId":"OG003","spread":"15.8","value":"-3.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Global health status/QoL: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.0","value":"-5.2"},{"groupId":"OG001","spread":"19.0","value":"-3.6"},{"groupId":"OG002","spread":"18.4","value":"-3.0"},{"groupId":"OG003","spread":"21.7","value":"-7.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Global health status/QoL: Change at EOT"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.0","value":"0.1"},{"groupId":"OG001","spread":"15.7","value":"-0.1"},{"groupId":"OG002","spread":"18.1","value":"-1.0"},{"groupId":"OG003","spread":"20.0","value":"0.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"-2.2"},{"groupId":"OG001","spread":"14.8","value":"0.5"},{"groupId":"OG002","spread":"19.5","value":"0.4"},{"groupId":"OG003","spread":"19.7","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.6","value":"-4.1"},{"groupId":"OG001","spread":"15.2","value":"-0.9"},{"groupId":"OG002","spread":"16.9","value":"-0.4"},{"groupId":"OG003","spread":"19.9","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.6","value":"-2.3"},{"groupId":"OG001","spread":"15.3","value":"-0.7"},{"groupId":"OG002","spread":"13.2","value":"2.2"},{"groupId":"OG003","spread":"23.6","value":"-2.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.7","value":"-0.9"},{"groupId":"OG001","spread":"15.1","value":"-2.0"},{"groupId":"OG002","spread":"15.1","value":"1.5"},{"groupId":"OG003","spread":"17.7","value":"-0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.6","value":"-0.9"},{"groupId":"OG001","spread":"15.8","value":"-1.5"},{"groupId":"OG002","spread":"14.8","value":"1.7"},{"groupId":"OG003","spread":"13.5","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.4","value":"0.3"},{"groupId":"OG001","spread":"17.6","value":"-2.6"},{"groupId":"OG002","spread":"15.3","value":"6.1"},{"groupId":"OG003","spread":"24.7","value":"-2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"14.9","value":"1.2"},{"groupId":"OG001","spread":"19.4","value":"-4.7"},{"groupId":"OG002","spread":"19.3","value":"-3.3"},{"groupId":"OG003","spread":"29.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.5","value":"0.4"},{"groupId":"OG001","spread":"15.0","value":"2.5"},{"groupId":"OG002","spread":"13.7","value":"-1.0"},{"groupId":"OG003","spread":"21.6","value":"6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"7.1","value":"2.1"},{"groupId":"OG001","spread":"16.8","value":"-3.5"},{"groupId":"OG002","spread":"12.6","value":"-3.3"},{"groupId":"OG003","spread":"24.0","value":"5.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"16"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"-1.2"},{"groupId":"OG001","spread":"5.9","value":"-4.2"},{"groupId":"OG002","spread":"9.6","value":"-11.1"},{"groupId":"OG003","spread":"11.8","value":"-8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"4.8","value":"11.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"5.9","value":"12.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"8.3"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"12.7","value":"19.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.9","value":"-4.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"31.2","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Global health status/QoL: Change at PT/Discontin."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.9","value":"86.7"},{"groupId":"OG001","spread":"22.5","value":"87.2"},{"groupId":"OG002","spread":"22.0","value":"86.6"},{"groupId":"OG003","spread":"23.2","value":"88.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Role functioning: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.3","value":"-2.8"},{"groupId":"OG001","spread":"10.9","value":"-0.8"},{"groupId":"OG002","spread":"16.6","value":"-1.0"},{"groupId":"OG003","spread":"18.3","value":"4.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"29.1","value":"-19.4"},{"groupId":"OG001","spread":"16.3","value":"0.2"},{"groupId":"OG002","spread":"27.6","value":"-15.2"},{"groupId":"OG003","spread":"19.6","value":"-2.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.4","value":"-10.6"},{"groupId":"OG001","spread":"9.0","value":"1.6"},{"groupId":"OG002","spread":"20.9","value":"-16.7"},{"groupId":"OG003","spread":"25.3","value":"-1.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.6","value":"-13.0"},{"groupId":"OG001","spread":"16.6","value":"0.2"},{"groupId":"OG002","spread":"27.5","value":"-13.3"},{"groupId":"OG003","spread":"17.5","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.7","value":"-11.1"},{"groupId":"OG001","spread":"18.4","value":"-0.6"},{"groupId":"OG002","spread":"21.5","value":"-9.6"},{"groupId":"OG003","spread":"17.5","value":"-0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.4","value":"-9.7"},{"groupId":"OG001","spread":"19.0","value":"0.4"},{"groupId":"OG002","spread":"21.3","value":"-8.2"},{"groupId":"OG003","spread":"21.2","value":"-2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.8","value":"-8.4"},{"groupId":"OG001","spread":"21.3","value":"0.3"},{"groupId":"OG002","spread":"19.7","value":"-9.0"},{"groupId":"OG003","spread":"19.0","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.0","value":"-11.1"},{"groupId":"OG001","spread":"20.5","value":"0.6"},{"groupId":"OG002","spread":"22.3","value":"-10.4"},{"groupId":"OG003","spread":"22.7","value":"0.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.2","value":"-5.8"},{"groupId":"OG001","spread":"18.3","value":"-0.5"},{"groupId":"OG002","spread":"22.9","value":"-11.6"},{"groupId":"OG003","spread":"20.1","value":"0.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"111"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.6","value":"-9.9"},{"groupId":"OG001","spread":"21.5","value":"0.9"},{"groupId":"OG002","spread":"24.0","value":"-8.8"},{"groupId":"OG003","spread":"21.3","value":"0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.5","value":"-9.2"},{"groupId":"OG001","spread":"23.0","value":"-1.9"},{"groupId":"OG002","spread":"24.5","value":"-9.5"},{"groupId":"OG003","spread":"21.3","value":"-0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"105"},{"groupId":"OG001","value":"105"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.4","value":"-11.2"},{"groupId":"OG001","spread":"20.7","value":"0.0"},{"groupId":"OG002","spread":"23.5","value":"-7.9"},{"groupId":"OG003","spread":"25.7","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"100"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.5","value":"-8.5"},{"groupId":"OG001","spread":"19.3","value":"-1.7"},{"groupId":"OG002","spread":"23.2","value":"-7.7"},{"groupId":"OG003","spread":"22.3","value":"3.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.5","value":"-6.6"},{"groupId":"OG001","spread":"19.7","value":"-1.3"},{"groupId":"OG002","spread":"25.0","value":"-10.2"},{"groupId":"OG003","spread":"24.8","value":"-3.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.2","value":"-8.7"},{"groupId":"OG001","spread":"17.2","value":"-0.4"},{"groupId":"OG002","spread":"25.2","value":"-8.2"},{"groupId":"OG003","spread":"26.3","value":"0.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.6","value":"-8.1"},{"groupId":"OG001","spread":"22.2","value":"-4.5"},{"groupId":"OG002","spread":"25.9","value":"-8.3"},{"groupId":"OG003","spread":"24.3","value":"-2.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Role functioning: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.0","value":"-4.7"},{"groupId":"OG001","spread":"23.2","value":"-1.3"},{"groupId":"OG002","spread":"25.0","value":"-4.2"},{"groupId":"OG003","spread":"27.6","value":"-6.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Role functioning: Change at End Of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.8","value":"2.0"},{"groupId":"OG001","spread":"17.6","value":"1.8"},{"groupId":"OG002","spread":"19.0","value":"1.2"},{"groupId":"OG003","spread":"26.9","value":"5.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Role functioning: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.7","value":"0.9"},{"groupId":"OG001","spread":"17.3","value":"3.0"},{"groupId":"OG002","spread":"20.1","value":"0.4"},{"groupId":"OG003","spread":"24.5","value":"5.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Role functioning: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.2","value":"2.7"},{"groupId":"OG001","spread":"21.1","value":"0.2"},{"groupId":"OG002","spread":"21.3","value":"0.4"},{"groupId":"OG003","spread":"28.0","value":"7.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Role functioning: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.8","value":"2.4"},{"groupId":"OG001","spread":"20.3","value":"0.8"},{"groupId":"OG002","spread":"18.2","value":"0.6"},{"groupId":"OG003","spread":"29.0","value":"4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Role functioning: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.3","value":"5.3"},{"groupId":"OG001","spread":"16.6","value":"-1.3"},{"groupId":"OG002","spread":"11.1","value":"3.9"},{"groupId":"OG003","spread":"29.3","value":"7.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Role functioning: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.5","value":"-1.4"},{"groupId":"OG001","spread":"20.0","value":"-4.0"},{"groupId":"OG002","spread":"11.7","value":"4.4"},{"groupId":"OG003","spread":"13.9","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Role functioning: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.2","value":"3.5"},{"groupId":"OG001","spread":"17.4","value":"-1.7"},{"groupId":"OG002","spread":"14.7","value":"1.1"},{"groupId":"OG003","spread":"35.5","value":"16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Role functioning: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.2","value":"6.2"},{"groupId":"OG001","spread":"20.5","value":"-7.3"},{"groupId":"OG002","spread":"14.1","value":"6.7"},{"groupId":"OG003","spread":"38.6","value":"14.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Role functioning: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.6","value":"7.6"},{"groupId":"OG001","spread":"10.0","value":"-2.0"},{"groupId":"OG002","spread":"11.8","value":"5.6"},{"groupId":"OG003","spread":"41.8","value":"26.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Role functioning: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.3","value":"6.9"},{"groupId":"OG001","spread":"14.8","value":"-5.6"},{"groupId":"OG002","spread":"18.3","value":"3.3"},{"groupId":"OG003","spread":"43.5","value":"23.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Role functioning: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"7.1"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"19.2","value":"11.1"},{"groupId":"OG003","spread":"11.8","value":"8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Role functioning: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.5","value":"27.8"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"23.6","value":"16.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Role functioning: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.6","value":"16.7"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Role functioning: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.5","value":"27.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Role functioning: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.6","value":"-8.3"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"17.2","value":"11.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Role functioning: Change at PT/Discontin."},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.6","value":"89.6"},{"groupId":"OG001","spread":"20.8","value":"88.2"},{"groupId":"OG002","spread":"21.2","value":"87.7"},{"groupId":"OG003","spread":"19.9","value":"90.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Social functioning: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.3","value":"1.4"},{"groupId":"OG001","spread":"12.0","value":"0.8"},{"groupId":"OG002","spread":"14.8","value":"2.1"},{"groupId":"OG003","spread":"8.7","value":"0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.9","value":"-15.0"},{"groupId":"OG001","spread":"13.8","value":"0.8"},{"groupId":"OG002","spread":"18.9","value":"-7.5"},{"groupId":"OG003","spread":"13.4","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.0","value":"-9.1"},{"groupId":"OG001","spread":"13.3","value":"5.6"},{"groupId":"OG002","spread":"17.4","value":"-5.6"},{"groupId":"OG003","spread":"20.3","value":"-2.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.9","value":"-8.0"},{"groupId":"OG001","spread":"16.6","value":"2.2"},{"groupId":"OG002","spread":"23.8","value":"-10.2"},{"groupId":"OG003","spread":"13.7","value":"3.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"82"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"-8.3"},{"groupId":"OG001","spread":"16.9","value":"2.7"},{"groupId":"OG002","spread":"18.2","value":"-7.7"},{"groupId":"OG003","spread":"17.0","value":"4.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"118"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"80"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"-8.1"},{"groupId":"OG001","spread":"17.8","value":"2.3"},{"groupId":"OG002","spread":"21.1","value":"-7.4"},{"groupId":"OG003","spread":"17.9","value":"1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.5","value":"-7.1"},{"groupId":"OG001","spread":"18.1","value":"1.7"},{"groupId":"OG002","spread":"20.6","value":"-7.5"},{"groupId":"OG003","spread":"13.5","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"76"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.7","value":"-9.4"},{"groupId":"OG001","spread":"17.6","value":"3.3"},{"groupId":"OG002","spread":"18.5","value":"-9.5"},{"groupId":"OG003","spread":"18.6","value":"2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"116"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.2","value":"-7.2"},{"groupId":"OG001","spread":"17.6","value":"1.9"},{"groupId":"OG002","spread":"22.4","value":"-11.4"},{"groupId":"OG003","spread":"17.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"69"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.7","value":"-8.0"},{"groupId":"OG001","spread":"17.0","value":"4.5"},{"groupId":"OG002","spread":"22.9","value":"-9.6"},{"groupId":"OG003","spread":"17.2","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.6","value":"-8.3"},{"groupId":"OG001","spread":"17.7","value":"2.2"},{"groupId":"OG002","spread":"23.0","value":"-7.9"},{"groupId":"OG003","spread":"16.0","value":"0.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.2","value":"-11.0"},{"groupId":"OG001","spread":"19.7","value":"1.7"},{"groupId":"OG002","spread":"22.8","value":"-8.2"},{"groupId":"OG003","spread":"21.5","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.9","value":"-8.7"},{"groupId":"OG001","spread":"16.1","value":"0.0"},{"groupId":"OG002","spread":"23.4","value":"-8.7"},{"groupId":"OG003","spread":"16.3","value":"-0.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.4","value":"-8.6"},{"groupId":"OG001","spread":"15.1","value":"1.4"},{"groupId":"OG002","spread":"23.1","value":"-9.9"},{"groupId":"OG003","spread":"21.6","value":"-2.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.2","value":"-10.6"},{"groupId":"OG001","spread":"15.7","value":"-0.4"},{"groupId":"OG002","spread":"22.2","value":"-9.1"},{"groupId":"OG003","spread":"16.5","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.2","value":"-8.3"},{"groupId":"OG001","spread":"21.1","value":"-1.9"},{"groupId":"OG002","spread":"25.2","value":"-10.2"},{"groupId":"OG003","spread":"17.7","value":"1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"89"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Social functioning: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.8","value":"-6.1"},{"groupId":"OG001","spread":"25.8","value":"1.2"},{"groupId":"OG002","spread":"23.3","value":"-5.5"},{"groupId":"OG003","spread":"21.2","value":"-3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Social functioning: Change at End of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"-1.7"},{"groupId":"OG001","spread":"15.4","value":"2.7"},{"groupId":"OG002","spread":"16.2","value":"1.2"},{"groupId":"OG003","spread":"19.5","value":"1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Social functioning: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.3","value":"-2.6"},{"groupId":"OG001","spread":"15.0","value":"4.2"},{"groupId":"OG002","spread":"13.9","value":"0.0"},{"groupId":"OG003","spread":"14.1","value":"2.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Social functioning: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.5","value":"3.4"},{"groupId":"OG001","spread":"15.4","value":"2.7"},{"groupId":"OG002","spread":"18.3","value":"0.0"},{"groupId":"OG003","spread":"17.4","value":"5.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"41"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Social functioning: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"-0.7"},{"groupId":"OG001","spread":"14.7","value":"1.6"},{"groupId":"OG002","spread":"13.6","value":"2.5"},{"groupId":"OG003","spread":"18.0","value":"-1.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Social functioning: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.7","value":"2.8"},{"groupId":"OG001","spread":"16.0","value":"0.9"},{"groupId":"OG002","spread":"11.4","value":"4.9"},{"groupId":"OG003","spread":"10.7","value":"0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Social functioning: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"20.8","value":"0.7"},{"groupId":"OG001","spread":"14.3","value":"6.1"},{"groupId":"OG002","spread":"13.3","value":"4.4"},{"groupId":"OG003","spread":"13.0","value":"-1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Social functioning: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.6","value":"2.6"},{"groupId":"OG001","spread":"20.1","value":"1.7"},{"groupId":"OG002","spread":"13.9","value":"2.2"},{"groupId":"OG003","spread":"12.0","value":"2.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"32"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Social functioning: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.3","value":"2.5"},{"groupId":"OG001","spread":"19.2","value":"0.0"},{"groupId":"OG002","spread":"10.5","value":"3.3"},{"groupId":"OG003","spread":"13.0","value":"1.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Social functioning: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.2","value":"9.1"},{"groupId":"OG001","spread":"21.1","value":"2.0"},{"groupId":"OG002","spread":"5.9","value":"-2.1"},{"groupId":"OG003","spread":"18.3","value":"3.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Social functioning: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"15.7","value":"9.8"},{"groupId":"OG001","spread":"16.6","value":"6.9"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"32.5","value":"10.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Social functioning: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.9","value":"7.1"},{"groupId":"OG001","spread":"0.0","value":"0.0"},{"groupId":"OG002","spread":"0.0","value":"0.0"},{"groupId":"OG003","spread":"11.8","value":"-8.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Social functioning: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.6","value":"27.8"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Social functioning: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"11.8","value":"25.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Social functioning: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"9.6","value":"27.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Social functioning: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.4","value":"-4.2"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"10.5","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Social functioning: Change at PT/Discontinuation"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.2","value":"18.4"},{"groupId":"OG001","spread":"25.4","value":"17.0"},{"groupId":"OG002","spread":"23.2","value":"17.2"},{"groupId":"OG003","spread":"24.6","value":"18.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"title":"Insomnia: Cycle 1 Day 1 (Baseline)"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.8","value":"11.1"},{"groupId":"OG001","spread":"14.2","value":"-3.0"},{"groupId":"OG002","spread":"22.7","value":"2.1"},{"groupId":"OG003","spread":"20.7","value":"1.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"24"},{"groupId":"OG001","value":"22"},{"groupId":"OG002","value":"16"},{"groupId":"OG003","value":"19"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 1 Day 8"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"29.6","value":"6.8"},{"groupId":"OG001","spread":"19.6","value":"1.0"},{"groupId":"OG002","spread":"26.1","value":"9.6"},{"groupId":"OG003","spread":"21.2","value":"-4.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"132"},{"groupId":"OG001","value":"139"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 1 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.6","value":"9.1"},{"groupId":"OG001","spread":"23.3","value":"-3.2"},{"groupId":"OG002","spread":"18.7","value":"6.7"},{"groupId":"OG003","spread":"22.1","value":"-7.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"21"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"17"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 1 Day 22"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.9","value":"0.8"},{"groupId":"OG001","spread":"22.6","value":"-1.2"},{"groupId":"OG002","spread":"24.8","value":"2.4"},{"groupId":"OG003","spread":"19.9","value":"-5.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"127"},{"groupId":"OG001","value":"142"},{"groupId":"OG002","value":"83"},{"groupId":"OG003","value":"84"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 2 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.7","value":"5.9"},{"groupId":"OG001","spread":"25.2","value":"0.5"},{"groupId":"OG002","spread":"28.7","value":"2.1"},{"groupId":"OG003","spread":"23.0","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"134"},{"groupId":"OG002","value":"80"},{"groupId":"OG003","value":"81"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 2 Day 15"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.7","value":"0.6"},{"groupId":"OG001","spread":"23.0","value":"-1.3"},{"groupId":"OG002","spread":"28.1","value":"-0.4"},{"groupId":"OG003","spread":"22.0","value":"-2.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"81"},{"groupId":"OG003","value":"78"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 3 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.6","value":"2.2"},{"groupId":"OG001","spread":"25.0","value":"-1.0"},{"groupId":"OG002","spread":"26.1","value":"3.4"},{"groupId":"OG003","spread":"23.1","value":"-4.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"119"},{"groupId":"OG001","value":"129"},{"groupId":"OG002","value":"78"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 4 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.4","value":"2.4"},{"groupId":"OG001","spread":"23.8","value":"0.3"},{"groupId":"OG002","spread":"26.9","value":"3.2"},{"groupId":"OG003","spread":"22.7","value":"-5.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"110"},{"groupId":"OG001","value":"117"},{"groupId":"OG002","value":"72"},{"groupId":"OG003","value":"64"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 5 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.6","value":"3.1"},{"groupId":"OG001","spread":"25.6","value":"1.8"},{"groupId":"OG002","spread":"26.5","value":"3.4"},{"groupId":"OG003","spread":"24.3","value":"-4.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"112"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"63"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 6 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.6","value":"4.7"},{"groupId":"OG001","spread":"25.6","value":"-0.3"},{"groupId":"OG002","spread":"23.8","value":"3.4"},{"groupId":"OG003","spread":"17.4","value":"-2.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"106"},{"groupId":"OG001","value":"108"},{"groupId":"OG002","value":"68"},{"groupId":"OG003","value":"59"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 7 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.5","value":"4.2"},{"groupId":"OG001","spread":"29.1","value":"0.6"},{"groupId":"OG002","spread":"29.9","value":"7.7"},{"groupId":"OG003","spread":"18.6","value":"-6.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"104"},{"groupId":"OG001","value":"106"},{"groupId":"OG002","value":"65"},{"groupId":"OG003","value":"53"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 8 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"27.8","value":"3.3"},{"groupId":"OG001","spread":"27.1","value":"0.7"},{"groupId":"OG002","spread":"28.6","value":"6.3"},{"groupId":"OG003","spread":"21.9","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"100"},{"groupId":"OG001","value":"101"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"52"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 9 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.9","value":"1.7"},{"groupId":"OG001","spread":"22.0","value":"0.7"},{"groupId":"OG002","spread":"27.1","value":"4.2"},{"groupId":"OG003","spread":"19.6","value":"-1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"96"},{"groupId":"OG001","value":"97"},{"groupId":"OG002","value":"63"},{"groupId":"OG003","value":"47"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 10 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.0","value":"0.7"},{"groupId":"OG001","spread":"25.5","value":"-0.7"},{"groupId":"OG002","spread":"32.0","value":"5.3"},{"groupId":"OG003","spread":"18.1","value":"1.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"93"},{"groupId":"OG001","value":"93"},{"groupId":"OG002","value":"57"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 11 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.6","value":"0.7"},{"groupId":"OG001","spread":"27.7","value":"0.0"},{"groupId":"OG002","spread":"29.2","value":"3.6"},{"groupId":"OG003","spread":"23.8","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"89"},{"groupId":"OG001","value":"91"},{"groupId":"OG002","value":"55"},{"groupId":"OG003","value":"48"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 12 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"26.4","value":"4.1"},{"groupId":"OG001","spread":"31.7","value":"3.8"},{"groupId":"OG002","spread":"29.0","value":"6.2"},{"groupId":"OG003","spread":"22.4","value":"-1.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"82"},{"groupId":"OG001","value":"88"},{"groupId":"OG002","value":"54"},{"groupId":"OG003","value":"45"}],"units":"Participants"}],"title":"Insomnia: Change at Cycle 13 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"25.3","value":"-3.0"},{"groupId":"OG001","spread":"28.8","value":"1.3"},{"groupId":"OG002","spread":"32.4","value":"3.5"},{"groupId":"OG003","spread":"26.6","value":"0.4"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"123"},{"groupId":"OG001","value":"125"},{"groupId":"OG002","value":"67"},{"groupId":"OG003","value":"75"}],"units":"Participants"}],"title":"Insomnia: Change at End Of Treatment"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.9","value":"-4.4"},{"groupId":"OG001","spread":"25.2","value":"-1.8"},{"groupId":"OG002","spread":"24.5","value":"-2.4"},{"groupId":"OG003","spread":"22.6","value":"-0.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"74"},{"groupId":"OG002","value":"56"},{"groupId":"OG003","value":"38"}],"units":"Participants"}],"title":"Insomnia: Change at PT 13 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"21.9","value":"-2.6"},{"groupId":"OG001","spread":"28.2","value":"0.5"},{"groupId":"OG002","spread":"23.0","value":"-1.4"},{"groupId":"OG003","spread":"22.5","value":"-3.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"90"},{"groupId":"OG001","value":"72"},{"groupId":"OG002","value":"47"},{"groupId":"OG003","value":"35"}],"units":"Participants"}],"title":"Insomnia: Change at PT 26 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.7","value":"-5.9"},{"groupId":"OG001","spread":"29.6","value":"-0.5"},{"groupId":"OG002","spread":"27.9","value":"-2.4"},{"groupId":"OG003","spread":"23.7","value":"-5.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"79"},{"groupId":"OG001","value":"68"},{"groupId":"OG002","value":"42"},{"groupId":"OG003","value":"33"}],"units":"Participants"}],"title":"Insomnia: Change at PT 39 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"24.3","value":"-3.9"},{"groupId":"OG001","spread":"26.6","value":"0.5"},{"groupId":"OG002","spread":"26.0","value":"-2.5"},{"groupId":"OG003","spread":"26.0","value":"-8.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"76"},{"groupId":"OG001","value":"62"},{"groupId":"OG002","value":"27"},{"groupId":"OG003","value":"25"}],"units":"Participants"}],"title":"Insomnia: Change at PT 52 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"23.6","value":"-6.3"},{"groupId":"OG001","spread":"21.8","value":"1.8"},{"groupId":"OG002","spread":"33.1","value":"-3.9"},{"groupId":"OG003","spread":"22.5","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"53"},{"groupId":"OG001","value":"38"},{"groupId":"OG002","value":"17"},{"groupId":"OG003","value":"18"}],"units":"Participants"}],"title":"Insomnia: Change at PT 65 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"28.5","value":"-2.2"},{"groupId":"OG001","spread":"30.6","value":"1.0"},{"groupId":"OG002","spread":"27.8","value":"-4.4"},{"groupId":"OG003","spread":"26.1","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"46"},{"groupId":"OG001","value":"33"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Insomnia: Change at PT 78 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"16.2","value":"-4.0"},{"groupId":"OG001","spread":"25.9","value":"-1.1"},{"groupId":"OG002","spread":"21.3","value":"-4.4"},{"groupId":"OG003","spread":"26.4","value":"-2.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"33"},{"groupId":"OG001","value":"29"},{"groupId":"OG002","value":"15"},{"groupId":"OG003","value":"12"}],"units":"Participants"}],"title":"Insomnia: Change at PT 91 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.8","value":"-4.9"},{"groupId":"OG001","spread":"27.8","value":"4.0"},{"groupId":"OG002","spread":"22.2","value":"0.0"},{"groupId":"OG003","spread":"11.1","value":"-3.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"27"},{"groupId":"OG001","value":"25"},{"groupId":"OG002","value":"10"},{"groupId":"OG003","value":"9"}],"units":"Participants"}],"title":"Insomnia: Change at PT 104 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"18.3","value":"-9.1"},{"groupId":"OG001","spread":"30.1","value":"-7.8"},{"groupId":"OG002","spread":"16.7","value":"0.0"},{"groupId":"OG003","spread":"29.8","value":"-13.3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"22"},{"groupId":"OG001","value":"17"},{"groupId":"OG002","value":"9"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Insomnia: Change at PT 117 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"22.1","value":"-7.8"},{"groupId":"OG001","spread":"20.7","value":"-8.3"},{"groupId":"OG002","spread":"27.9","value":"6.7"},{"groupId":"OG003","spread":"14.9","value":"-6.7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"17"},{"groupId":"OG001","value":"12"},{"groupId":"OG002","value":"5"},{"groupId":"OG003","value":"5"}],"units":"Participants"}],"title":"Insomnia: Change at PT 130 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.8","value":"-14.3"},{"groupId":"OG001","spread":"23.6","value":"-16.7"},{"groupId":"OG002","spread":"33.3","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"7"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Insomnia: Change at PT 143 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"-11.1"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG003","spread":"0.0","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"2"}],"units":"Participants"}],"title":"Insomnia: Change at PT 156 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"0.0","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Insomnia: Change at PT 169 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"19.2","value":"-11.1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"0"},{"groupId":"OG003","value":"0"}],"units":"Participants"}],"title":"Insomnia: Change at PT 182 Weeks"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"17.8","value":"0.0"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG001","spread":"NA","value":"0.0"},{"groupId":"OG002","spread":"25.1","value":"5.6"},{"comment":"1 participant was analyzed, so standard deviation is not applicable.","groupId":"OG003","spread":"NA","value":"0.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"6"},{"groupId":"OG003","value":"1"}],"units":"Participants"}],"title":"Insomnia: Change at PT/Discont."}],"denoms":[{"counts":[{"groupId":"OG000","value":"138"},{"groupId":"OG001","value":"147"},{"groupId":"OG002","value":"87"},{"groupId":"OG003","value":"89"}],"units":"Participants"}],"description":"European Organisation for Research and Treatment of Cancer 30-Item Quality of Life Questionnaire assesses 8 symptoms, function, financial difficulties, and a global health status/health-related quality of life (HRQoL). Most questions use a 4-point scale (1 'Not at all' to 4 'Very much';2 questions use a 7-point scale (1 'very poor' to 7 'Excellent'). Scores were averaged and transformed to a 0-100 scale. Higher scores for the function and HRQoL represent higher levels of functioning and HRQoL, higher scores for the symptom represent higher levels of symptoms/problems, higher score for financial difficulty represent higher level of perceived financial burden of treatment. Changes of 5-10 points are considered to represent a minimally important difference to participants. A positive value means an increase, and negative value means a decrease in score at the indicated time-point relative to the score at baseline (Cycle 1 Day 1).","dispersionType":"Standard Deviation","groups":[{"description":"Participants with completely resected Stage IIC, IIIA, or IIIB cutaneous melanoma) received vemurafenib, 960 mg twice daily, in 28-day cycles, for up to 52 weeks","id":"OG000","title":"Cohort 1 Vemurafenib"},{"description":"Participants with completely resected Stage IIC, IIIA, or IIIB cutaneous melanoma) received vemurafenib-matching placebo twice daily, in 28-day cycles, for up to 52 weeks","id":"OG001","title":"Cohort 1 Placebo"},{"description":"Participants with Stage IIIC cutaneous melanoma received vemurafenib, 960 mg twice daily, in 28-day cycles, for up to 52 weeks","id":"OG002","title":"Cohort 2 Vemurafenib"},{"description":"Participants with Stage IIIC cutaneous melanoma received vemurafenib-matching placebo twice daily, in 28-day cycles, for up to 52 weeks","id":"OG003","title":"Cohort 2 Placebo"}],"paramType":"MEAN","populationDescription":"The patient-reported outcome (PRO)-evaluable population included all participants who received at least one dose of vemurafenib and who had both a baseline assessment and at least one post-baseline QLQ-C30 assessment that generated a score.","reportingStatus":"POSTED","timeFrame":"Day 1, Day 8, Day 15, Day 22 of Cycle 1;Day 1, Day 15 of Cycle 2;Day 1 Cycles 3-13;end of treatment(up to 13 months);every 13 weeks thereafter until recurrence or occurrence of a new primary melanoma (up to 17-Apr-17 data cut-off,approximately 4.5 years)","title":"Change From Baseline in European Organisation for Research and Treatment of Cancer (EORTC) 30-Item Quality of Life Questionnaire (QLQ-C30) Score","type":"SECONDARY","unitOfMeasure":"score on a scale"}