{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"366.71","value":"9114.43"},{"groupId":"OG001","spread":"159.47","value":"2825.09"},{"groupId":"OG002","spread":"287.76","value":"1313.76"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"9"},{"groupId":"OG002","value":"15"}],"units":"Participants"}],"title":"Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","spread":"383.94","value":"15229.27"},{"groupId":"OG001","spread":"79.68","value":"3358.78"},{"groupId":"OG002","spread":"505.00","value":"3731.16"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"5"},{"groupId":"OG002","value":"3"}],"units":"Participants"}],"title":"Cycle 3 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"21"},{"groupId":"OG001","value":"9"},{"groupId":"OG002","value":"15"}],"units":"Participants"}],"description":"AUC (TAU) is the area measured under the concentration-time curve taken over the dosing interval.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Dose Escalation: Uninfected hepatocellular carcinoma (HCC) participants received nivolumab 0.1/0.3/1/3/10 mg/kg every 2 weeks","id":"OG000","title":"Cohort 1 Uninfected HCC"},{"description":"Dose Escalation: Hepatitis C (HCV)-infected participants received nivolumab 0.3/1/3 mg/kg every 2 weeks","id":"OG001","title":"Cohort 1 HCV Infected"},{"description":"Dose Escalation: Hepatitis B (HBV)-infected participants received nivolumab 0.1/0.3/1/3 mg/kg every 2 weeks","id":"OG002","title":"Cohort 1 HBV Infected"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"All treated participants in Cohort 1 with baseline and at least 1 post-baseline assessment; uninfected HCC, HCV-infected, and HBV-infected participants reported together as pre-specified.","reportingStatus":"POSTED","timeFrame":"At Cycle 1 Day 1 and Cycle 3 Day 1 (Each Cycle = 2 Weeks)","title":"Area Under the Serum Concentration Time Curve in the Dosing Interval [AUC(TAU)]","type":"SECONDARY","unitOfMeasure":"ug.h/mL"}