{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"1.0","upperLimit":"25.2","value":"3.00"},{"groupId":"OG001","lowerLimit":"0.9","upperLimit":"25.2","value":"2.98"},{"groupId":"OG002","lowerLimit":"0.9","upperLimit":"23.9","value":"3.00"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"10"},{"groupId":"OG002","value":"15"}],"units":"Participants"}],"title":"Cycle 1 Day 1"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"0.9","upperLimit":"24.3","value":"12.75"},{"groupId":"OG001","lowerLimit":"1.0","upperLimit":"24.5","value":"12.28"},{"groupId":"OG002","lowerLimit":"0.8","upperLimit":"25.7","value":"24.13"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"8"},{"groupId":"OG001","value":"6"},{"groupId":"OG002","value":"3"}],"units":"Participants"}],"title":"Cycle 3 Day 1"}],"denoms":[{"counts":[{"groupId":"OG000","value":"23"},{"groupId":"OG001","value":"10"},{"groupId":"OG002","value":"15"}],"units":"Participants"}],"description":"Tmax is the time taken to reach the maximum observed serum concentration (Cmax).","dispersionType":"Full Range","groups":[{"description":"Dose Escalation: Uninfected hepatocellular carcinoma (HCC) participants received nivolumab 0.1/0.3/1/3/10 mg/kg every 2 weeks","id":"OG000","title":"Cohort 1 Uninfected HCC"},{"description":"Dose Escalation: Hepatitis C (HCV)-infected participants received nivolumab 0.3/1/3 mg/kg every 2 weeks","id":"OG001","title":"Cohort 1 HCV Infected"},{"description":"Dose Escalation: Hepatitis B (HBV)-infected participants received nivolumab 0.1/0.3/1/3 mg/kg every 2 weeks","id":"OG002","title":"Cohort 1 HBV Infected"}],"paramType":"MEDIAN","populationDescription":"All treated participants in Cohort 1 with baseline and at least 1 post-baseline assessment; uninfected HCC, HCV-infected, and HBV-infected participants reported together as pre-specified.","reportingStatus":"POSTED","timeFrame":"At Cycle 1 Day 1 and Cycle 3 Day 1 (Each Cycle = 2 Weeks)","title":"Time of Maximum Observed Serum Concentration (Tmax)","type":"SECONDARY","unitOfMeasure":"Hour"}