{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"46.2","value":"129"},{"groupId":"OG001","spread":"86.9","value":"155"},{"groupId":"OG002","spread":"58.8","value":"311"},{"groupId":"OG003","spread":"35.6","value":"313"},{"groupId":"OG004","spread":"50.3","value":"461"}]}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"6"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"8"},{"groupId":"OG004","value":"5"}],"units":"Participants"}],"description":"Maximum measured concentration (Cmax) of afatinib as determined on day 3 of course 1 for patients in Part A","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Patients received oral administration of afatinib 90mg film-coated tablet once daily for three days, repeated every 14 days, during each 28-day cycle.","id":"OG000","title":"Afatinib 90mg"},{"description":"Patients received oral administration of afatinib 120mg film-coated tablet once daily for three days, repeated every 14 days, during each 28-day cycle.","id":"OG001","title":"Afatinib 120mg"},{"description":"Patients received oral administration of afatinib 150mg film-coated tablet once daily for three days, repeated every 14 days, during each 28-day cycle.","id":"OG002","title":"Afatinib 150mg"},{"description":"Patients received oral administration of afatinib 160mg film-coated tablet once daily for three days, repeated every 14 days, during each 28-day cycle.","id":"OG003","title":"Afatinib 160mg"},{"description":"Patients received oral administration of afatinib 200mg film-coated tablet once daily for three days, repeated every 14 days, during each 28-day cycle.","id":"OG004","title":"Afatinib 200mg"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"Pharmacokinetic set which included all patients treated in part A who were documented to have taken at least one dose of afatinib and who had in addition at least one valid afatinib concentration available.","reportingStatus":"POSTED","timeFrame":"47 hours (h) 55 minutes (min), 49h, 50h, 51h, 52h, 53h, 54h, 55h after first dose administration (on day 3 of course 1)","title":"Cmax of Afatinib on Day 3 of Course 1","type":"SECONDARY","unitOfMeasure":"ng/mL"}