{"description":"AEs were recorded for each patient from their first dose of trial drug treatment. An event occurring after the patient has provided informed consent but before the first dose of study medication will be collected as part of the medical history. AEs were collected for all 131 patients who were dosed with study drug.All-cause Mortality: From first dose of study drug up to end of the study (approximately up to 57 months).","eventGroups":[{"deathsNumAffected":0,"deathsNumAtRisk":4,"description":"Dose escalation starting at 25 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase I: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG000","otherNumAffected":3,"otherNumAtRisk":4,"seriousNumAffected":1,"seriousNumAtRisk":4,"title":"Phase I: X-396 (Ensartinib) at 25 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":3,"description":"Dose escalation starting at 50 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase I: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG001","otherNumAffected":3,"otherNumAtRisk":3,"seriousNumAffected":1,"seriousNumAtRisk":3,"title":"Phase I: X-396 (Ensartinib) at 50 mg"},{"deathsNumAffected":1,"deathsNumAtRisk":5,"description":"Dose escalation starting at 100 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase I: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG002","otherNumAffected":4,"otherNumAtRisk":5,"seriousNumAffected":2,"seriousNumAtRisk":5,"title":"Phase I: X-396 (Ensartinib) at 100 mg"},{"deathsNumAffected":1,"deathsNumAtRisk":11,"description":"Dose escalation starting at 200 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase I: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG003","otherNumAffected":9,"otherNumAtRisk":11,"seriousNumAffected":6,"seriousNumAtRisk":11,"title":"Phase I: X-396 (Ensartinib) at 200 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":4,"description":"Dose escalation starting at 225 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase I: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG004","otherNumAffected":2,"otherNumAtRisk":4,"seriousNumAffected":2,"seriousNumAtRisk":4,"title":"Phase I: X-396 (Ensartinib) at 225 mg"},{"deathsNumAffected":0,"deathsNumAtRisk":10,"description":"Dose escalation starting at 250 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase I: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG005","otherNumAffected":9,"otherNumAtRisk":10,"seriousNumAffected":5,"seriousNumAtRisk":10,"title":"Phase I: X-396 (Ensartinib) at 250 mg"},{"deathsNumAffected":3,"deathsNumAtRisk":94,"description":"Dose expansion starting at 225 mg, oral once or twice a day, 28-day cycle. Number of Cycles: until progression or unacceptable toxicity develops\n\nPhase II: X-396 (ensartinib): Oral, ALK inhibitor","id":"EG006","otherNumAffected":84,"otherNumAtRisk":94,"seriousNumAffected":41,"seriousNumAtRisk":94,"title":"Phase II: X-396 (Ensartinib) at 225 mg"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Blood and lymphatic system disorders","sourceVocabulary":"MedDRA (15.0)","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":4,"numEvents":1},{"groupId":"EG001","numAffected":0,"numAtRisk":3,"numEvents":0},{"groupId":"EG002","numAffected":1,"numAtRisk":5,"numEvents":1},{"groupId":"EG003","numAffected":0,"numAtRisk":11,"numEvents":0},{"groupId":"EG004","numAffected":0,"numAtRisk":4,"numEvents":0},{"groupId":"EG005","numAffected":0,"numAtRisk":10,"numEvents":0},{"groupId":"EG006","numAffected":11,"numAtRisk":94,"numEvents":11}],"term":"Blood and 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