{"eventGroups":[{"deathsNumAffected":1,"deathsNumAtRisk":19,"description":"CONDITIONING: Patients receive busulfan IV over 3 hours on days -6 to -3, melphalan IV over 20 minutes on day -2, and bortezomib IV over 3-5 seconds on days -6, -3, 1, and 4.\n\nTRANSPLANT: Patients undergo autologous PBSCT on day 0.\n\nBusulfan: Given IV\n\nMelphalan: Given IV\n\nBortezomib: Given IV\n\nAutologous Hematopoietic Stem Cell Transplantation: Undergo autologous PBSCT\n\nPeripheral Blood Stem Cell Transplantation: Undergo autologous PBSCT","id":"EG000","otherNumAffected":19,"otherNumAtRisk":19,"seriousNumAffected":1,"seriousNumAtRisk":19,"title":"Treatment (Busulfan, Melphalan, Bortezomib, Autologous PBSCT)"}],"frequencyThreshold":"5","otherEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":17,"numAtRisk":19}],"term":"Electrolyte abnormalities"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":19}],"term":"Oral mucositis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":17,"numAtRisk":19}],"term":"Dysphagia/Odynophagia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Endocrine disorders","stats":[{"groupId":"EG000","numAffected":13,"numAtRisk":19}],"term":"Transaminitis"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":18,"numAtRisk":19}],"term":"Nausea and/or vomitting"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":15,"numAtRisk":19}],"term":"Diarrhea"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Gastrointestinal disorders","stats":[{"groupId":"EG000","numAffected":3,"numAtRisk":19}],"term":"Abdominal pain"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"General disorders","stats":[{"groupId":"EG000","numAffected":4,"numAtRisk":19}],"term":"Fever without neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Immune system disorders","stats":[{"groupId":"EG000","numAffected":14,"numAtRisk":19}],"term":"Febrile neutropenia"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3, 4 \\& 5","organSystem":"Infections and infestations","stats":[{"groupId":"EG000","numAffected":8,"numAtRisk":19}],"term":"Infections"},{"assessmentType":"SYSTEMATIC_ASSESSMENT","notes":"Grade 3 \\& 4","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":2,"numAtRisk":19}],"term":"Noninfectious pulmonary toxicity"}],"seriousEvents":[{"assessmentType":"SYSTEMATIC_ASSESSMENT","organSystem":"Respiratory, thoracic and mediastinal disorders","stats":[{"groupId":"EG000","numAffected":1,"numAtRisk":19}],"term":"Death - 70 days after the autologous stem cell transplant"}],"timeFrame":"Up to 2 years"}