{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"8.6","upperLimit":"10.3","value":"9.4"},{"groupId":"OG001","lowerLimit":"9.3","upperLimit":"10.7","value":"10.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"50"},{"groupId":"OG001","value":"85"}],"units":"Participants"}],"title":"Attention/Concentration at 9 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"9.1","upperLimit":"11.1","value":"10.1"},{"groupId":"OG001","lowerLimit":"9.0","upperLimit":"10.6","value":"9.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"40"},{"groupId":"OG001","value":"69"}],"units":"Participants"}],"title":"Attention/Concentration at 30 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"8.3","upperLimit":"10.4","value":"9.3"},{"groupId":"OG001","lowerLimit":"9.1","upperLimit":"11.3","value":"10.2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"28"},{"groupId":"OG001","value":"44"}],"units":"Participants"}],"title":"Attention/Concentration at 60 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"90.0","upperLimit":"98.7","value":"94.3"},{"groupId":"OG001","lowerLimit":"95.9","upperLimit":"102.1","value":"99.0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"48"},{"groupId":"OG001","value":"94"}],"units":"Participants"}],"title":"Estimated IQ at 9 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"96.2","upperLimit":"106.4","value":"101.3"},{"groupId":"OG001","lowerLimit":"99.1","upperLimit":"106.7","value":"102.9"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"44"},{"groupId":"OG001","value":"72"}],"units":"Participants"}],"title":"Estimated IQ at 30 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"91.2","upperLimit":"103.5","value":"97.3"},{"groupId":"OG001","lowerLimit":"100.0","upperLimit":"108.9","value":"104.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"45"}],"units":"Participants"}],"title":"Estimated IQ at 60 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"85.2","upperLimit":"94.9","value":"90.1"},{"groupId":"OG001","lowerLimit":"88.3","upperLimit":"95.3","value":"91.8"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"48"},{"groupId":"OG001","value":"94"}],"units":"Participants"}],"title":"Processing Speed at 9 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"87.7","upperLimit":"99.0","value":"93.4"},{"groupId":"OG001","lowerLimit":"92.3","upperLimit":"98.9","value":"95.6"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"44"},{"groupId":"OG001","value":"70"}],"units":"Participants"}],"title":"Processing Speed at 30 months"},{"categories":[{"measurements":[{"groupId":"OG000","lowerLimit":"82.2","upperLimit":"98.0","value":"90.1"},{"groupId":"OG001","lowerLimit":"93.1","upperLimit":"101.9","value":"97.5"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"29"},{"groupId":"OG001","value":"45"}],"units":"Participants"}],"title":"Processing Speed at 60 months"}],"denoms":[{"counts":[{"groupId":"OG000","value":"70"},{"groupId":"OG001","value":"113"}],"units":"Participants"}],"description":"Estimated scores for the cognitive functions of processing speed, attention/concentration, and estimated IQ were assessed using the age-appropriate version of the Wechsler Scales of Intelligence. The range for the Processing Speed Index (PSI) is 45 to 155, with a mean of 100 and a standard deviation of 15. Estimated IQ was estimated using 2 subtests from the Wechsler Scales of Intelligence to derive a standard score with a mean of 100 and standard deviation of 15 with a range of 45 to 158. Scores from the 2 subtests were summed and translated to a standard score using published procedures. Attention/concentration was measured by the Digit Span subtest score from the Wechsler Scales of Intelligence. Subset scores have a range of 1-19, with a mean of 10 and standard deviation of 3. Higher scores on all these measures indicate higher or better cognitive performance, lower scores indicate lower or worse cognitive functioning.","dispersionType":"95% Confidence Interval","groups":[{"description":"Patients receive induction therapy comprising carboplatin intravenously (IV) over 15-60 minutes on day 1 and etoposide IV over 60-120 minutes on days 1-3 of courses 1, 3, and 5. Patients also receive ifosfamide IV over 60 minutes and etoposide over 60-120 minutes on days 1-5 of courses 2, 4, and 6. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients achieving CR or PR undergo 3-dimensional conformal radiation therapy (3DRT) or intensity modulated radiation therapy (IMRT) once daily (QD) 5 days a week for 6 weeks. Patients with normalization of markers who fail to achieve CR or PR are strongly recommended to undergo second-look surgery. Patients who achieve CR or PR after second-look surgery undergo 3DRT or IMRT QD 5 days a week for 6 weeks.","id":"OG000","title":"Stratum 1 Localized Non-Germinomatous Germ Cell Tumors (NGGCT)"},{"description":"Patients receive induction therapy comprising carboplatin IV over 15-60 minutes on day 1 and etoposide IV over 60-120 minutes on days 1-3. Treatment repeats every 21 days for 4 courses in the absence of disease progression or unacceptable toxicity. Patients with CR or continued CR (CCR) undergo 3DRT or IMRT QD 5 days a week for 4 weeks. Patients with normalization of markers who fail to achieve CR or PR are strongly recommended to undergo second-look surgery. Patients found to have fibrosis, scar, mature teratoma, or non-viable tumor undergo 3DRT or IMRT QD 5 days a week for 4 weeks. Patients with stable disease (SD) or PR with \\> 0.5 cm (suprasellar) or \\> 1 cm (pineal) but =\\< 1.5 cm residual disease do not undergo second-look surgery and undergo 3DRT or IMRT QD 5 days a week for 4 weeks.","id":"OG001","title":"Stratum 2 Localized Germinoma"}],"paramType":"MEAN","populationDescription":"All eligible patients who received the radiation therapy were included as evaluable patients for analysis.","reportingStatus":"POSTED","timeFrame":"Up to 5 years","title":"Neurocognitive Function Using the ALTE07C1 Protocol","type":"PRIMARY","unitOfMeasure":"Standardized Scores"}