{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","spread":"44.3","value":"11.467"},{"groupId":"OG001","spread":"35.1","value":"11.085"},{"comment":"Geometric coefficient of variation could not be calculated as only one participant was analyzed at the specified time point.","groupId":"OG002","spread":"NA","value":"18.470"},{"groupId":"OG003","spread":"39.1","value":"18.036"},{"groupId":"OG004","spread":"62.9","value":"6.720"},{"groupId":"OG005","spread":"42.1","value":"13.769"},{"groupId":"OG006","spread":"62.8","value":"13.589"},{"groupId":"OG007","spread":"45.2","value":"13.707"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"9"},{"groupId":"OG006","value":"32"},{"groupId":"OG007","value":"9"}],"units":"Participants"}],"title":"Week1;n=3,4,1,3,4,9,32,9"},{"categories":[{"measurements":[{"comment":"Geometric coefficient of variation could not be calculated as only one participant was analyzed at the specified time point.","groupId":"OG000","spread":"NA","value":"13.082"},{"groupId":"OG001","spread":"60.5","value":"11.955"},{"comment":"Geometric coefficient of variation could not be calculated as only one participant was analyzed at the specified time point.","groupId":"OG002","spread":"NA","value":"24.277"},{"groupId":"OG003","spread":"21.4","value":"23.823"},{"groupId":"OG004","spread":"54.5","value":"9.535"},{"groupId":"OG005","spread":"47.3","value":"23.296"},{"groupId":"OG006","spread":"48.4","value":"27.029"},{"groupId":"OG007","spread":"35.8","value":"26.188"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"1"},{"groupId":"OG001","value":"2"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"6"},{"groupId":"OG006","value":"16"},{"groupId":"OG007","value":"6"}],"units":"Participants"}],"title":"Week3;n=1,2,1,3,4,6,16,6"}],"denoms":[{"counts":[{"groupId":"OG000","value":"3"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"9"},{"groupId":"OG006","value":"32"},{"groupId":"OG007","value":"9"}],"units":"Participants"}],"description":"Blood samples were collected at the indicated time points for pharmacokinetic analysis of GSK525762.","dispersionType":"Geometric Coefficient of Variation","groups":[{"description":"Participants were administered once daily oral dose of 2 mg GSK525762.","id":"OG000","title":"Part 1: GSK525762 2 mg QD"},{"description":"Participants were administered once daily oral dose of 4 mg GSK525762.","id":"OG001","title":"Part 1: GSK525762 4 mg QD"},{"description":"Participants were administered once daily oral dose of 8 mg GSK525762.","id":"OG002","title":"Part 1: GSK525762 8 mg QD"},{"description":"Participants were administered once daily oral dose of 16 mg GSK525762.","id":"OG003","title":"Part 1: GSK525762 16 mg QD"},{"description":"Participants were administered once daily oral dose of 30 mg GSK525762.","id":"OG004","title":"Part 1: GSK525762 30 mg QD"},{"description":"Participants were administered once daily oral dose of 60 mg GSK525762.","id":"OG005","title":"Part 1: GSK525762 60 mg QD"},{"description":"Participants were administered once daily oral dose of 80 mg GSK525762.","id":"OG006","title":"Part 1: GSK525762 80 mg QD"},{"description":"Participants were administered once daily oral dose of 100 mg GSK525762.","id":"OG007","title":"Part 1: GSK525762 100 mg QD"}],"paramType":"GEOMETRIC_MEAN","populationDescription":"PK Parameter Population. Only those participants with data available at the specified time points were analyzed (indicated by n=X in category titles)","reportingStatus":"POSTED","timeFrame":"pre-dose,0.25,0.5,1,2,4,8,12,24 and 48 hours post-dose at Week1 Day1 and Week 3 Day 4","title":"Apparent Clearance of GSK525762-Part 1 QD","type":"SECONDARY","unitOfMeasure":"Liter per hour"}