{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"3"},{"groupId":"OG002","value":"8"},{"groupId":"OG003","value":"5"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"3"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"22"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"title":"DBP; Increase to Grade 1;n=11,14,22,19,19,12"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"4"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"6"},{"groupId":"OG005","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"22"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"title":"DBP; Increase to Grade 2;n=11,14,22,19,19,12"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"0"},{"groupId":"OG002","value":"1"},{"groupId":"OG003","value":"2"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"2"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"22"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"title":"DBP; Increase to Grade 3/4;n=11,14,22,19,19,12"},{"categories":[{"measurements":[{"groupId":"OG000","value":"4"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"2"},{"groupId":"OG003","value":"9"},{"groupId":"OG004","value":"7"},{"groupId":"OG005","value":"1"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"21"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"title":"SBP; Increase to Grade 1;n=11,14,21,19,19,12"},{"categories":[{"measurements":[{"groupId":"OG000","value":"2"},{"groupId":"OG001","value":"4"},{"groupId":"OG002","value":"11"},{"groupId":"OG003","value":"3"},{"groupId":"OG004","value":"4"},{"groupId":"OG005","value":"7"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"21"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"title":"SBP; Increase to Grade 2;n=11,14,21,19,19,12"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"},{"groupId":"OG001","value":"1"},{"groupId":"OG002","value":"3"},{"groupId":"OG003","value":"1"},{"groupId":"OG004","value":"1"},{"groupId":"OG005","value":"0"}]}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"21"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"title":"SBP; Increase to Grade 3/4;n=11,14,21,19,19,12"}],"denoms":[{"counts":[{"groupId":"OG000","value":"11"},{"groupId":"OG001","value":"14"},{"groupId":"OG002","value":"22"},{"groupId":"OG003","value":"19"},{"groupId":"OG004","value":"19"},{"groupId":"OG005","value":"12"}],"units":"Participants"}],"description":"SBP and DBP were measured in a supine or semi-recumbent position after at least 5 minutes rest for the participant. Grading of SBP and DBP were done using NCI-CTCAE version 4.0 where, SBP (millimeters of mercury): Grade 0 (\\<120), Grade 1 (120-139), Grade 2 (140-159), Grade 3/4 (\\>=160) and DBP: Grade 0 (\\<80), Grade 1 (80-89), Grade 2 (90-99), Grade 3/4 (\\>=100). An increase is defined as an increase in CTCAE grade relative to baseline grade. Baseline is the most recent, non-missing value from a central laboratory prior to or on the first study treatment dose date. Data for worst case post-Baseline is presented.","groups":[{"description":"Participants with NUT Midline Carcinoma (NMC) were administered continuous once daily oral dose of 75 mg GSK525762","id":"OG000","title":"Participants With NMC"},{"description":"Participants with small cell lung cancer(SCLC) were administered continuous once daily oral dose of 75 mg GSK525762","id":"OG001","title":"Participants With SCLC"},{"description":"Participants with Castrate-Resistant Prostate Cancer (CRPC) were administered continuous once daily oral dose of 75 mg GSK525762","id":"OG002","title":"Participants With CRPC"},{"description":"Participants with Triple Negative Breast Cancer (TNBC) were administered continuous once daily oral dose of 75 mg GSK525762","id":"OG003","title":"Participants With TNBC"},{"description":"Participants with estrogen receptor positive breast cancer (ER+BC) were administered continuous once daily oral dose of 75 mg GSK525762","id":"OG004","title":"Participants With ER+BC"},{"description":"Participants with Gastrointestinal Stromal Tumor (GIST) were administered continuous once daily oral dose of 75 mg GSK525762","id":"OG005","title":"Participants With GIST"}],"paramType":"COUNT_OF_PARTICIPANTS","populationDescription":"All Treated Population. Only those participants with data available at Baseline and the specified time points were analyzed (indicated by n=X in category titles).","reportingStatus":"POSTED","timeFrame":"Baseline (pre-dose Week1 Day1) and median of 1.41 months of drug exposure","title":"Number of Participants With Changes in Blood Pressure From Baseline-Part 2","type":"PRIMARY","unitOfMeasure":"Participants"}