{"classes":[{"categories":[{"measurements":[{"groupId":"OG000","value":"28"}]}],"title":"sCR/CR"},{"categories":[{"measurements":[{"groupId":"OG000","value":"31"}]}],"title":"VGPR"},{"categories":[{"measurements":[{"groupId":"OG000","value":"11"}]}],"title":"PR"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"SD"},{"categories":[{"measurements":[{"groupId":"OG000","value":"0"}]}],"title":"PD"},{"categories":[{"measurements":[{"groupId":"OG000","value":"1"}]}],"title":"Not Evaluable"}],"denoms":[{"counts":[{"groupId":"OG000","value":"72"}],"units":"Participants"}],"description":"The best response for all patients who had at least one dose of drug was measured.\n\nResponse categories:\n\nStringent Complete Response (sCR), Complete Remission(CR), Very Good Partial Remission(VGPR), Partial Remission (PR), Progressive Disease (PD), Stable Disease (SD).\n\nThe response is evaluated based on the IMWG criteria.","groups":[{"description":"Carfilzomib, Clarithromycin (Biaxin®), Lenalidomide (Revlimid®), and Dexamethasone (Decadron®) \\[Car-BiRD\\]\n\nCar Phase:\n\ncarfilzomib: 45 mg/m2 IV on days 1, 2, 8, 9, 15 and 16 of each 28 day cycles. Dexamethasone: 20 mg orally on days 1, 2, 8, 9, 15 and 16 of a 28 day cycle, while receiving carfilzomib.\n\nBiRD Phase:\n\nClarithromycin: 500 mg twice a day for each 28 day cycle of BiRD treatment. BiRD begins after carfilzomib treatment has been completed.\n\nLenalidomide: 25 mg orally days 1-21 for each 28 day cycle of BiRD treatment. BiRD begins after carfilzomib treatment has been completed.\n\nDexamethasone: 40 mg orally on days 1, 8, 15 and 22 of each 28 day cycle of BiRD treatment. BiRD begins after carfilzomib treatment has been completed.\n\nMaintenance Phase:\n\nLenalidomide: 10 mg orally on days 1-21 or each 28 day cycle of maintenance. Maintenance begins after BiRD treatment has been completed.","id":"OG000","title":"Car-BiRD Therapy"}],"paramType":"COUNT_OF_PARTICIPANTS","reportingStatus":"POSTED","timeFrame":"From baseline to best response, up to 116 weeks.","title":"Response to Car-BiRD Treatment.","type":"PRIMARY","unitOfMeasure":"Participants"}